Se Alleviated Pb-Caused Neurotoxicity in Chickens: SPS2-GPx1-GSH-IL-2/IL-17-NO Pathway, Selenoprotein Suppression, Oxidative Stress, and Inflammatory Injury

Antioxidants, Год журнала: 2024, Номер 13(3), С. 370 - 370

Опубликована: Март 18, 2024

Lead (Pb), a heavy metal environmental pollutant, poses threat to the health of humans and birds. Inflammation is one most common pathological phenomena in case illness poisoning. However, underlying mechanisms inflammation remain unclear. The cerebellum thalamus are important parts nervous system. To date, there have been no reports Pb inducing animal cerebellums or thalami. Selenium (Se) can relieve Therefore, we aimed explore mechanism by which Se alleviates toxicity thalami chickens establishing chicken or/and treatment model. Our results demonstrated that exposure caused inflammatory damage thalami, evidenced characteristics inflammation, decrease anti-inflammatory factors (interleukin (IL)-2 interferon-γ (INF-γ)), increase pro-inflammatory (IL-4, IL-6, IL-12β, IL-17, nitric oxide (NO)). Moreover, found IL-2/IL-17–NO pathway took part Pb-caused injury. above findings were reversed supplementation dietary Se, meaning relieved via pathway. In addition, an up-regulated oxidative index malondialdehyde (MDA) two down-regulated antioxidant indices (glutathione (GSH) total capacity (TAC)) recorded after received stimulation, indicating excess oxidant/antioxidant imbalance stress, stress mediated GSH–IL-2 axis. Interestingly, inhibited four glutathione peroxidase (GPx) family members (GPx1, GPx2, GPx3, GPx4), three deiodinase (Dio) (Dio1, Dio2, Dio3), fifteen other selenoproteins (selenophosphate synthetase 2 (SPS2), selenoprotein (Sel)H, SelI, SelK, SelM, SelO, SelP1, SelPb, SelS, SelT, SelU, (Sep)n1, Sepw1, Sepx1, Sep15), suggesting reduced resulted involving SPS2–GPx1–GSH supplementation, as expected, changes mentioned above, improved mitigated chickens. For first time, discovered SPS2–GPx1–GSH–IL-2/IL-17–NO involved complex conclusion, this study Pb-induced This offers novel insights into pollutant-caused poisoning provides theoretical basis for detoxification effect against toxic pollutants.

Язык: Английский

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Recent research progress on the biological functions, synthesis and applications of selenium nanoparticles

Journal of Chromatography B, Год журнала: 2025, Номер 1252, С. 124448 - 124448

Опубликована: Янв. 2, 2025

Язык: Английский

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A comprehensive review on potential role of selenium, selenoproteins and selenium nanoparticles in male fertility

Heliyon, Год журнала: 2024, Номер 10(15), С. e34975 - e34975

Опубликована: Июль 20, 2024

Selenium (Se), a component of selenoproteins and selenocompounds in the human body, is crucial for development male reproductive organs, DNA synthesis, thyroid hormone, metabolism, defence against infections oxidative damage. In testis, it must exceed desirable level since either shortage or an overabundance causes aberrant growth. The antioxidant properties selenium are essential preserving health. Selenoproteins, which have important structural enzymatic properties, control biological activities Se primarily. These proteins specifically role metabolism variety cellular processes, such as transport, hormone immunity, redox balance. nanoparticles (SeNPs) less hazardous than selenium-based inorganic organic materials. Upon being functionalized with active targeting ligands, they both biocompatible capable efficiently delivering combinations payloads to particular cells. this review, we discuss briefly chemistry, structure functions milestones selenoproteins. Next various factors influences infertility, selenoproteins, spermatogenesis fertility. Furthermore, molecular mechanism transport protective effects on stress, apoptosis inflammation. We also highlight critical contribution fertility spermatogenesis. Finally ends conclusion future perspectives.

Язык: Английский

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Selenium Nanoparticles as Neuroprotective Agents: Insights into Molecular Mechanisms for Parkinson’s Disease Treatment

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 5, 2024

Язык: Английский

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Selenium modulates bisphenol A-induced intestinal apoptosis, oxidative stress and autophagy in rats: A biochemical, histological and immunohistochemical study

Archives of Environmental & Occupational Health, Год журнала: 2025, Номер unknown, С. 1 - 13

Опубликована: Янв. 25, 2025

Bisphenol A (BPA) is a hazardous endocrine disruptor released into the environment during production of certain plastics used for covering food and beverage cans. In this work, we examined protective benefits selenium (Se) against intestinal damage induced by BPA in male rats. Rats were distributed randomly four groups. The first group received corn oil served as control. second was administered Se (1 mg/kg body weight; BW). third given oral (50 fourth group, BW) simultaneously. This experiment lasted eight weeks. Specimens from large intestine subjected to biochemical analysis antioxidants oxidative stress biomarkers, histological observation under light transmission electron microscopy immunohistochemistry autophagy apoptosis markers. BPA-exposed showed significantly elevated markers associated with significant decline tissues. resulted alterations such severe mucosal necrosis massive inflammatory cell infiltration. Ultra-structurally, same loss organelles, shrunken nuclei, abundant autophagosomes. Immunohistochemistry results demonstrated strong reactivity caspase-3 LC3 contrast reaction p62, which markedly diminished. These effects mitigated BPA+Se group. We concluded that BPA's harmful on are caused autophagy. may protect cells these could be useful trustworthy approach reducing toxicity.

Язык: Английский

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Bisphenol B restrains rat leydig cell function via H3K27me3/H3K9me3 histone modifications

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117847 - 117847

Опубликована: Фев. 1, 2025

As an alternative compound of bisphenol A (BPA), B (BPB) was widely used in plastic materials. The potential actions BPB on the function Leydig cells through regulation H3K27me3 and H3K9me3 remains unclear. Our goal to assess how influences cell via histone modifications mediated by H3K9me3. Male 56-day-old Sprague-Dawley rats were given with 0, 50, 100, 200 mg/kg/day oral administration for 14 days study impact rats. findings indicated that significantly reduced serum testosterone levels at dose 100 mg/kg follicle-stimulating hormone doses mg/kg, while increasing estradiol mg/kg. did not alter numbers CYP11A1+ SOX9+ Sertoli cells, but it downregulated expression key genes synthesis pathway (Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, Hsd11b1, Hsd17b3, Insl3) their corresponding protein levels. Notably, boosted expressions methylation markers like EEF1A1, SUZ12, EED, EZH2, H3K27me3, vivo. enhanced proximal promoters Lhcgr, Star ChIP PCR analyses. Furthermore, adult extracted cultured (0, 10, μM) alone or combination antagonist GSK-J4. results demonstrated decreased output, which counteracted GSK-J4 reverse BPB-mediated suppression. Additionally, elevated EEF1A2, vitro. could potentially hinder growth modulating indicate involvement (H3K27me3) BPB-induced steroidogenic dysfunction, emphasizing correlation between male reproductive toxicity.

Язык: Английский

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ROS acted as an initial role in selenium nanoparticles alleviating insecticide chlorpyrifos-induced oxidative stress, pyroptosis, and intestinal barrier dysfunction in porcine intestinal epithelial cells

Pesticide Biochemistry and Physiology, Год журнала: 2025, Номер unknown, С. 106418 - 106418

Опубликована: Апрель 1, 2025

Язык: Английский

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Melatonin Alleviates BPA-Induced Testicular Apoptosis and Endoplasmic Reticulum Stress

Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(3), С. 95 - 95

Опубликована: Март 8, 2024

Background: The impact of melatonin on bisphenol A (BPA)-induced testicular apoptosis and endoplasmic reticulum (ER) stress was explored. Methods: mice received BPA (50 mg/kg) by gavage for 30 days while being injected with 20 mg/kg melatonin. Protein expressions were detected western blotting. Terminal Deoxynucleotidyl Transferase dUTP Nick End Labeling (TUNEL) assay measured cell apoptosis. Testosterone quantified employing enzyme-linked immunosorbent (ELISA). Results: Melatonin promoted the development seminiferous tubules, restored orderly arrangement germ cells, increased epithelial layers in tubules BPA-treated mice. Moreover, mouse markedly upregulated receptor 1A (MTNR1A) Receptor 2 (MTNR2) downregulating ER molecular chaperones glucose-regulated protein 78 (GRP78) 94 (GRP94). Furthermore, it decreased p-PERK, p-IRE1, ATF6α, as well apoptotic proteins cysteine-containing aspartate-specific proteases-12 (caspase-12) cleaved proteases-3 (cleaved caspase-3), causing suppression Additionally, levels cytochrome P450 17α-hydroxylase/20-lyase (CYP17A1), 17β-hydroxysteroid dehydrogenase 3 (17β-HSD3), 3β-hydroxysteroid 4 (3β-HSD4), ER, elevated testosterone tissue. Conclusions: can significantly alleviate induced BPA, which is because upregulation expression inhibition stress-related pathways, enhancement synthesis.

Язык: Английский

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Combination treatment of zinc and selenium intervention ameliorated BPA-exposed germ cell damage in SD rats: elucidation of molecular mechanisms

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(9), С. 6685 - 6704

Опубликована: Март 18, 2024

Язык: Английский

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The Ameliorative Effects of Selenium Nanoparticles (SeNPs) on Diabetic Rat Model: A Narrative Review

Sains Malaysiana, Год журнала: 2023, Номер 52(7), С. 2037 - 2053

Опубликована: Июль 31, 2023

The emergence of nanotechnology has become more popular, and the progress had sparked much development in nanoparticle synthesis, including selenium. Studies associated with therapeutic abilities physicochemical properties selenium nanoparticles (SeNPs) are rapidly growing gaining interest from many researchers. This review discusses on fundamental components selenium, different approaches synthesizing nanoparticles, its remedial potential biomedical application. Herein, primary focus will be given to action mechanism improving diabetes mellitus symptoms complications animal studies. It is known that an important micronutrient found humans, plants animals can incorporated as selenoprotein human body. Analysis comparison findings enlighten SeNPs demonstrated ameliorative effect due their antidiabetic, antioxidant, anti-inflammatory lipid-lowering characteristics.

Язык: Английский

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