The complex relationship between obesity and neurodegenerative diseases: an updated review

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Ноя. 9, 2023

Obesity is a global epidemic, affecting roughly 30% of the world’s population and predicted to rise. This disease results from genetic, behavioral, societal, environmental factors, leading excessive fat accumulation, due insufficient energy expenditure. The adipose tissue, once seen as simple storage depot, now recognized complex organ with various functions, including hormone regulation modulation metabolism, inflammation, homeostasis. associated low-grade inflammatory state has been linked neurodegenerative diseases like multiple sclerosis (MS), Alzheimer’s (AD), Parkinson’s (PD). Mechanistically, reduced expandability leads hypertrophic adipocytes, triggering insulin leptin resistance, blood-brain barrier disruption, altered brain neuronal atrophy, cognitive decline. impacts disorders through shared underlying mechanisms, underscoring its potential modifiable risk factor for these diseases. Nevertheless, further research needed fully grasp intricate connections between obesity neurodegeneration. Collaborative efforts in this field hold promise innovative strategies address relationship develop effective prevention treatment methods, which also includes specific diets physical activities, ultimately improving quality life health.

Язык: Английский

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Mediterranean Lifestyle: More Than a Diet, A Way of Living (and Thriving)

Endocrine Metabolic & Immune Disorders - Drug Targets, Год журнала: 2024, Номер 24(15), С. 1785 - 1793

Опубликована: Март 1, 2024

Although the Mediterranean Diet (MedDiet) may appear simple and locally inspired based on provided definitions, mounting evidence reveals that adopting a dietary pattern aligned with MedDiet principles can yield numerous health benefits. Also, stands as gold standard in preventive medicine, so it is not simplistic diet centered around specific ingredients or cooking methods; instead, emerges from distinctive way of life (lifestyle) inherent to region. This lifestyle encapsulates essential components balanced life, including frugality moderation food consumption, utilization seasonal traditional products, focus sourced, eco-friendly, biodiverse items, personal engagement culinary preparation, emphasis conviviality social activities during meal regular physical activity, adequate hydration, sufficient rest. In this review, we will establish interconnections links between various aspects diet, how these pillars reflect region's lifestyle, each element necessary part others. Finally, seamless integration involvement, rest, exercise, be explored provide holistic view its harmony.

Язык: Английский

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The Benefits of the Mediterranean Diet on Inflamm-Aging in Childhood Obesity

Nutrients, Год журнала: 2024, Номер 16(9), С. 1286 - 1286

Опубликована: Апрель 25, 2024

(1) Background: Numerous elements of the Mediterranean diet (MD) have antioxidant and anti-inflammatory qualities. (2) Methods: We present a narrative review potential benefits dietary pattern in mitigating aging-related inflammation (inflamm-aging) associated with childhood obesity. The mechanisms underlying chronic obesity are also discussed. A total 130 papers were included after screening abstracts full texts. (3) Results: complex interplay between obesity, inflammation, related comorbidities is documented. MD emerges as promising for inflammation. Studies suggest that may contribute to weight control, improved lipid profiles, insulin sensitivity, endothelial function, thereby reducing risk metabolic syndrome children adolescents (4) Conclusions: While evidence supporting effects pediatric still evolving, existing literature underscores its preventive therapeutic strategy. However, adherence remains low among adolescents, necessitating targeted interventions promote healthier habits. Future high-quality intervention studies necessary elucidate specific impact on diverse populations comorbidities.

Язык: Английский

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An Appraisal of the Oleocanthal-Rich Extra Virgin Olive Oil (EVOO) and Its Potential Anticancer and Neuroprotective Properties

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(24), С. 17323 - 17323

Опубликована: Дек. 10, 2023

Dietary consumption of olive oil represents a key pillar the Mediterranean diet, which has been shown to exert beneficial effects on human health, such as prevention chronic non-communicable diseases like cancers and neurodegenerative diseases, among others. These health benefits are partly mediated by high-quality extra virgin (EVOO), is produced mostly in countries directly made from olives, fruit tree (Olea europaea L.). Preclinical evidence supports existence antioxidant anti-inflammatory properties exerted polyphenol oleocanthal, belongs EVOO minor polar compound subclass secoiridoids (like oleuropein). This narrative review aims describe well potential anticancer neuroprotective actions this polyphenol. Based recent evidence, we also discuss reasons underlying need include concentrations oleocanthal other polyphenols EVOO's nutrition facts label. Finally, report our personal experience production certified organic with "Protected Designation Origin" (PDO), was obtained olives three different cultivars (Rotondella, Frantoio, Leccino) harvested geographical areas located short distance one another (villages' names: Gorga Camella) within Southern Italy "Cilento, Vallo di Diano Alburni National Park" Campania Region (Province Salerno, Italy).

Язык: Английский

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Vitamin D3 affects the gut microbiota in an LPS-stimulated systemic inflammation mouse model

Microbes and Infection, Год журнала: 2023, Номер 25(8), С. 105180 - 105180

Опубликована: Июль 6, 2023

Язык: Английский

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Mediterranean ketogenic diet accounts for reduced pain frequency and intensity in patients with chronic migraine: A pilot study

Clinical Nutrition, Год журнала: 2024, Номер 43(8), С. 1781 - 1787

Опубликована: Июнь 19, 2024

SummaryBackgroundAn increasing amount of evidence suggests that migraine is a response to cerebral energy deficiencies or oxidative stress levels exceed antioxidant capacity. Current pharmacological options are inadequate in treating patients with chronic migraine, and growing interest focuses on nutritional approaches as non-pharmacological treatments. The ketogenic diet, mimicking fasting leads an elevation ketone bodies, therapeutic intervention targeting metabolism has recently shown great promise the prevention migraines. Moreover, Mediterranean elements like vegetables, nuts, herbs, spices, olive oil sources anti-inflammatory (omega-3 fatty acids, polyphenols, vitamins, essential minerals, probiotics) may create positive brain environment by reducing imbalance gut microbiome.MethodsOn basis these indications, combined Mediterranean-ketogenic diet was administered for 4 (T1) 8 weeks (T2), anthropometric estimations were collected at T1 T2 while biochemical parameters only T2.ResultsA significant reduction (p < 0.01) frequency intensity detected early dietary intervention, which associated reduced fat mass 0.001) well Homa index 0.05) insulin after weeks.ConclusionOverall, be considered effective outcomes body composition.

Язык: Английский

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Ambroxol attenuates detrimental effect of LPS-induced glia-mediated neuroinflammation, oxidative stress, and cognitive dysfunction in mice brain

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 6, 2025

Neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s (PD), are multifactorial. Among various factors, lipopolysaccharides (LPSs) from Gram-negative bacteria, E. coli , considered potential causative agents. Despite significant advancements in the field, there is still no cure. In this study, we investigated neuroprotective effects of ambroxol against LPS-induced neuroinflammation, oxidative stress, neurodegeneration, associated cognitive dysfunction. Intraperitoneal injection LPS (250 µg/kg every alternative day for a total seven doses over 14 days) triggered glial cell activation, neurodegeneration mouse brain. Ambroxol treatment (30 mg/kg/day significantly reduced neuroinflammation stress compared to LPS-treated mice. Immunoblotting immunofluorescence results showed that levels Toll-like receptor 4 (TLR4) kinase phospho-c-Jun N-terminal Kinase 1 (p-JNK). It also decreased astrocyte microglia activation cortex hippocampus LPS+ Amb-treated mice, indicated by downregulation GFAP Iba-1. Furthermore, ambroxol-reversed inhibiting inflammatory mediators, IL-1β TNF-α, through regulation transcription factor p-NFkB. Persistent disrupted natural antioxidant mechanisms, leading stress. upregulated markers, including Nrf-2, HO-1, SOD, which were downregulated group. Additionally, ambroxol-inhibited lipid peroxidation, maintaining malondialdehyde improves synaptic integrity upregulating biomarkers, PSD-95 SNAP-23. Overall, demonstrated anti-inflammatory, antioxidant, highlighting its benefits neurological disorders.

Язык: Английский

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Effects of Mediterranean Diet on Chronic Degenerative Diseases and Human Healthy Lifestyle

Nutrients, Год журнала: 2025, Номер 17(7), С. 1231 - 1231

Опубликована: Апрель 1, 2025

Noncommunicable diseases (NCDs), known as chronic diseases, including diabetes mellitus, obesity, cardiovascular kidney disease, neurodegenerative and cancers, represent an important public concern, leading to prolonged disability death [...].

Язык: Английский

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Nootropic foods in neurodegenerative diseases: mechanisms, challenges, and future

Translational Neurodegeneration, Год журнала: 2025, Номер 14(1)

Опубликована: Апрель 3, 2025

Neurodegenerative diseases (NDDs) such as Alzheimer's and Parkinson's disease are increasing globally represent a significant cause of age-related death in the population. Recent studies emphasize strong association between environmental stressors, particularly dietary factors, brain health neurodegeneration unsatisfactory outcomes. Despite ongoing efforts, efficiency current treatments for NDDs remains wanting. Considering this, nootropic foods with neuroprotective effects high interest part possible long-term therapeutic strategy to improve alleviate NDDs. However, since it is new emerging area food neuroscience, there limited information on mechanisms challenges consider this be successful intervention. Here, we seek address these gaps by presenting comprehensive review pathways or including mutual interactions governing metabolism, linkages NDDs, intake, properties foods. We also discuss in-depth intervention compounds patterns providing detailed exploration their action. Additionally, analyze demand, challenges, future directions development targeting

Язык: Английский

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Postpartum Depression Is Associated with Maternal Sociodemographic and Anthropometric Characteristics, Perinatal Outcomes, Breastfeeding Practices, and Mediterranean Diet Adherence

Nutrients, Год журнала: 2023, Номер 15(17), С. 3853 - 3853

Опубликована: Сен. 4, 2023

Postpartum depression, with a prevalence ranging between 14% and 25% worldwide, has been considered an urgent health concern that negatively affects both mothers' their infants' health. depression may affect maternal sociodemographic anthropometric parameters lifestyle factors. Nutrition recently identified as crucial factor for the management co-treatment of postpartum depression. This survey aims to determine possible association socio-demographic characteristics, perinatal outcomes, breastfeeding practices, Mediterranean diet (MD) adherence.This is cross-sectional survey, which was performed on 3941 women during period. assessed by Edinburgh Postnatal Depression Scale (EPDS). Anthropometric outcomes were retrieved from medical records. Sociodemographic data practices recorded face-to-face interviews enrolled mothers trained personnel. adherence MedDietScore. Both univariate multivariate binary logistic regression applied analyzing our data.Postpartum significantly associated lower educational level, Greek nationality, higher multiparity overweight/obesity postpartum, incidence caesarean section not breastfeeding, levels MD adherence. In analysis, independently BMI status, type delivery, after adjusting multiple confounding factors.This study provided evidence elevated compliance related decreased risk Additionally, parameters, practices. Future well-designed, prospective studies high-quality methodology should be obtain conclusive results.

Язык: Английский

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