The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development
Nutrients,
Год журнала:
2023,
Номер
15(20), С. 4486 - 4486
Опубликована: Окт. 23, 2023
Resveratrol
is
a
stilbenoid
from
red
grapes
that
possesses
strong
antioxidant
activity.
has
been
shown
to
have
anticancer
activity,
making
it
promising
drug
for
the
treatment
and
prevention
of
numerous
cancers.
Several
in
vitro
vivo
investigations
validated
resveratrol’s
capabilities,
demonstrating
its
ability
block
all
steps
carcinogenesis
(such
as
initiation,
promotion,
progression).
Additionally,
resveratrol
found
auxiliary
pharmacological
effects
such
anti-inflammatory,
cardioprotective,
neuroprotective
Despite
properties,
several
obstacles,
poor
solubility
bioavailability,
well
adverse
effects,
continue
be
key
obstacles
development.
This
review
critically
evaluates
clinical
trials
date
aims
develop
framework
into
clinically
viable
drug.
Язык: Английский
The Interplay of Mitochondrial Dysfunction in Oral Diseases: Recent Updates in Pathogenesis and Therapeutic Implications
Al-Hassan Soliman Wadan,
Mohamed Abdelsattar Ahmed,
Abdelnaser Hussein Ahmed
и другие.
Mitochondrion,
Год журнала:
2024,
Номер
78, С. 101942 - 101942
Опубликована: Авг. 6, 2024
Язык: Английский
Mitochondrial nucleic acids in innate immunity and beyond
Experimental & Molecular Medicine,
Год журнала:
2023,
Номер
55(12), С. 2508 - 2518
Опубликована: Дек. 1, 2023
Abstract
Mitochondria
participate
in
a
wide
range
of
cellular
processes.
One
essential
function
mitochondria
is
to
be
platform
for
antiviral
signaling
proteins
during
the
innate
immune
response
viral
infection.
Recently,
studies
have
revealed
that
mitochondrion-derived
DNAs
and
RNAs
are
recognized
as
non-self
molecules
act
immunogenic
ligands.
More
importantly,
cytosolic
release
these
mitochondrial
nucleic
acids
(mt-NAs)
closely
associated
with
pathogenesis
human
diseases
accompanying
aberrant
activation.
The
(mtDNAs)
via
BAX/BAK
activation
and/or
VDAC1
oligomerization
activates
inflammasome
assembly.
In
addition,
double-stranded
(mt-dsRNAs)
sensed
by
pattern
recognition
receptors
cytosol
induce
type
I
interferon
expression
initiate
apoptotic
programs.
Notably,
mt-NAs
also
mediate
adipocyte
differentiation
contribute
mitogenesis
thermogenesis.
this
review,
we
summarize
recent
pathways
regulated
mt-NAs,
emerging
physiological
roles
mt-NAs.
Язык: Английский
Mitochondrial Dysfunction in the Pathogenesis and Treatment of Oral Inflammatory Diseases
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15483 - 15483
Опубликована: Окт. 23, 2023
Oral
inflammatory
diseases
(OIDs)
include
many
common
such
as
periodontitis
and
pulpitis.
The
causes
of
OIDs
consist
microorganism,
trauma,
occlusal
factors,
autoimmune
dis-eases
radiation
therapy.
When
treated
unproperly,
not
only
affect
oral
health
but
also
pose
threat
to
people’s
overall
condition.
Therefore,
identifying
at
an
early
stage
exploring
new
therapeutic
strategies
are
important
tasks
for
oral-related
research.
Mitochondria
crucial
organelles
cellular
activities
disruptions
mitochondrial
function
metabolism
indirectly
influence
life
span.
Mitochondrial
dysfunction
has
been
implicated
in
polygenic
diseases,
including
cardiovascular
neurodegenerative
diseases.
Recently,
increasing
evidence
suggests
that
plays
a
critical
role
the
development
progression
its
associated
systemic
In
this
review,
we
elucidated
insights
into
involvement
responses
OIDs.
We
summarized
recent
research
progresses
on
treatment
targeting
discussed
underlying
mechanisms.
Язык: Английский
Taurine can restrict mtdsRNA mediated pyroptosis by enhancing mitophagy in nucleus pulposus cells
Опубликована: Апрель 15, 2025
Abstract
Mitochondrial
double-stranded
RNA
(mtdsRNA),
a
long-stranded
molecule
generated
by
bidirectional
transcription
of
the
circular
mitochondrial
genome,
can
trigger
type
1
interferon
response
activating
pattern
recognition
receptors
in
cytoplasm
during
dysfunction.
However,
its
regulatory
and
pathogenic
mechanisms
intervertebral
disc
degeneration
are
poorly
understood.
Here,
we
showed
that
mtdsRNA
was
abnormally
elevated
degenerative
nucleus
pulposus
tissues.
Furthermore,
found
leakage
into
could
cause
MAVS
oligomerization
binding
to
RLRs,
oligomerized
then
promote
cell
pyroptosis
NLRP3.
To
further
elucidate
upstream
mechanism
mtdsRNA,
performed
untargeted
metabolomics
analysis,
which
revealed
downregulation
taurine
under
external
stimuli
drive
an
imbalance
homeostasis.
RNA-seq
exogenous
supplementation
with
protected
cells
from
mtdsRNA-induced
increasing
mitophagy.
In
conclusion,
our
study
links
metabolism,
nucleic
acids
suggests
is
important
causative
potential
therapeutic
target
degeneration.
Язык: Английский
SLIRP promotes autoimmune diseases by amplifying antiviral signaling via positive feedback regulation
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 2, 2024
SUMMARY
The
abnormal
innate
immune
response
is
a
prominent
feature
underlying
autoimmune
diseases.
One
emerging
factor
that
can
trigger
dysregulated
activation
cytosolic
mitochondrial
double-stranded
RNAs
(mt-dsRNAs).
However,
the
mechanism
by
which
mt-dsRNAs
stimulate
responses
remains
poorly
understood.
Here,
we
discover
SRA
stem-loop
interacting
RNA
binding
protein
(SLIRP)
as
key
amplifier
of
mt-dsRNA-triggered
antiviral
signals.
In
diseases,
SLIRP
commonly
upregulated,
and
targeted
knockdown
dampens
interferon
response.
We
find
melanoma
differentiation-associated
gene
5
(MDA5)
exogenous
dsRNAs
upregulates
SLIRP,
then
stabilizes
promotes
their
release
to
activate
MDA5
further,
augmenting
Furthermore,
downregulation
partially
rescues
interferon-stimulated
expression
in
patients’
primary
cells
makes
vulnerable
certain
viral
infections.
Our
study
unveils
pivotal
mediator
through
positive
feedback
amplification
signaling.
Язык: Английский