Clinical rationale for dietary lutein supplementation in post COVID-19 and mRNA vaccine injury syndromes

F1000Research, Год журнала: 2024, Номер 13, С. 191 - 191

Опубликована: Март 15, 2024

Lutein, a plant-derived xanthophyl-carotenoid, is an exceptional antioxidant and anti-inflammatory constituent found in food. High dietary intake of lutein beneficial against eye disease, improves cardiometabolic health, protects from neurodegenerative diseases, for liver, kidney, respiratory health. Lutein oxidative nitrosative stress, both which play major role post-COVID mRNA vaccination injury syndromes. important natural agent therapeutic use stress chronic illnesses such as cardiovascular diseases cancer. It can also potentially inhibit spike protein-induced inflammation. Rich supplementation lutein, naturally derived non-biodegradable Extra Virgin Olive Oil (EVOO), most optimally be used during Due to its high oleic acid (OA) content, EVOO supports optimal absorption lutein. The main molecular pathways by the SARS-CoV-2 protein induces pathology, nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB) (AP)-1, suppressed Synergy with other compounds detoxification likely.

Язык: Английский

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Pulmonary redox imbalance drives early fibroproliferative response in moderate/severe coronavirus disease-19 acute respiratory distress syndrome and impacts long-term lung abnormalities

Annals of Intensive Care, Год журнала: 2024, Номер 14(1)

Опубликована: Май 12, 2024

COVID-19-associated pulmonary fibrosis remains frequent. This study aimed to investigate redox balance in COVID-19 ARDS patients and possible relationship with long-term lung abnormalities. Baseline data, chest CT scores, N-terminal peptide of alveolar collagen III (NT-PCP-III), transforming growth factor (TGF)-β1, superoxide dismutase (SOD), reduced glutathione (GSH), oxidized (GSSG) malondialdehyde (MDA) bronchoalveolar lavage fluid (BALF) were first collected compared between SARS-CoV-2 RNA positive moderate severe (n = 65, ARDS) negative non-ARDS requiring mechanical ventilation 63, non-ARDS). Then, correlations fibroproliferative (NT-PCP-III TGF-β1) markers analyzed within group, comparisons survivor non-survivor subgroups performed. Finally, follow-up survivors was performed analyze the abnormalities, 3 months after discharge. Compared group had significantly elevated scores (p < 0.001) NT-PCP-III 0.001), TGF-β1 GSSG MDA concentrations on admission, while decreased SOD GSH levels observed BALF. Both BALF from directly correlated inversely 0.001). Within non-survivors 28) showed significant fibroproliferation more imbalance than 37). Furthermore, according data 37), radiographic residual function impairment improved discharge associated early 0.01). Pulmonary occurring drives response increases risk death. Long-term abnormalities post-COVID-19 are imbalance.

Язык: Английский

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Clinical rationale for dietary lutein supplementation in long COVID and mRNA vaccine injury syndromes

F1000Research, Год журнала: 2024, Номер 13, С. 191 - 191

Опубликована: Авг. 6, 2024

Lutein, a plant-derived xanthophyl-carotenoid, is an exceptional antioxidant and anti-inflammatory constituent found in food. High dietary intake of lutein beneficial against eye disease, improves cardiometabolic health, protects from neurodegenerative diseases, for liver, kidney, respiratory health. Lutein oxidative nitrosative stress, both which play major role post-COVID mRNA vaccination injury syndromes. important natural agent therapeutic use stress chronic illnesses such as cardiovascular diseases cancer. It can also potentially inhibit spike protein-induced inflammation. Rich supplementation lutein, naturally derived non-biodegradable Extra Virgin Olive Oil (EVOO), most optimally be used during Due to its high oleic acid (OA) content, EVOO supports optimal absorption lutein. The main molecular pathways by the SARS-CoV-2 protein induces pathology, nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB) (AP)-1, suppressed Synergy with other compounds detoxification likely.

Язык: Английский

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Clinical rationale for dietary lutein supplementation in long COVID and mRNA vaccine injury syndromes

F1000Research, Год журнала: 2024, Номер 13, С. 191 - 191

Опубликована: Окт. 17, 2024

Lutein, a plant-derived xanthophyl-carotenoid, is an exceptional antioxidant and anti-inflammatory constituent found in food. High dietary intake of lutein beneficial against eye disease, improves cardiometabolic health, protects from neurodegenerative diseases, for liver, kidney, respiratory health. Lutein oxidative nitrosative stress, both which play major role long COVID mRNA vaccination injury syndromes. important natural agent therapeutic use stress chronic illnesses such as cardiovascular diseases cancer. It can also potentially inhibit spike protein-induced inflammation. Rich supplementation lutein, naturally derived non-biodegradable Extra Virgin Olive Oil (EVOO), most optimally be used during post-COVID Due to its high oleic acid (OA) content, EVOO supports optimal absorption lutein. The main molecular pathways by the SARS-CoV-2 protein induces pathology, nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB) (AP)-1, suppressed Synergy with other compounds detoxification likely.

Язык: Английский

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Prevalence and risk factors of long covid and its associated adverse work outcomes among workers in the manufacturing sector in Malaysia – a mixed-methods study protocol

Journal of Health Population and Nutrition, Год журнала: 2024, Номер 43(1)

Опубликована: Ноя. 25, 2024

Язык: Английский

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