Abstract
Background
The
disulfide
stress-induced
cell
death
known
as
disulfidptosis
is
characterized
by
the
disintegration
of
cytoskeletal
proteins
and
F-actin
a
result
an
excessive
buildup
disulfides
within
cell.
relationship
between
disulfidptosis-associated
long
non-coding
RNA
(lncRNA)
in
hepatocellular
carcinoma
(HCC)
progression
still
not
clearly
understood.
In
this
article,
we
aim
to
explore
crucial
role
lncRNA
HCC.
Methods
We
initially
obtained
related
HCC
clinical
data
from
TCGA.
genes
associated
with
were
identified
through
co-expression
analysis,
Cox
regression,
Lasso
regression.
Additionally,
established
prognostic
model
for
verification.
Results
risk
constructed
disulfidptosis-related
has
been
confirmed
be
good
predictor
high
low-risk
groups
patients
survival
curves,
independent
concordance
index
(C-index),
ROC
Kaplan–Meier
plots.
also
discovered
differences
response
immune
targets
anticancer
drugs
two
patients,
GDC0810,
Osimertinib,
Paclitaxel,
YK-4-279
being
more
effective
high-risk
group.
Conclusion
conclusion,
have
developed
that
can
guide
future
efforts
diagnose
treat
Experimental Hematology and Oncology,
Год журнала:
2024,
Номер
13(1)
Опубликована: Авг. 1, 2024
Abstract
Hepatocellular
carcinoma
(HCC)
is
a
highly
heterogeneous
malignancy
with
high
incidence,
recurrence,
and
metastasis
rates.
The
emergence
of
immunotherapy
has
improved
the
treatment
advanced
HCC,
but
problems
such
as
drug
resistance
immune-related
adverse
events
still
exist
in
clinical
practice.
immunosuppressive
tumor
microenvironment
(TME)
HCC
restricts
efficacy
essential
for
progression
metastasis.
Therefore,
it
necessary
to
elucidate
mechanisms
behind
TME
develop
apply
immunotherapy.
This
review
systematically
summarizes
pathogenesis
formation
TME,
by
which
accelerates
We
also
status
further
discuss
existing
challenges
potential
therapeutic
strategies
targeting
TME.
hope
inspire
optimizing
innovating
immunotherapeutic
comprehensively
understanding
structure
function
HCC.
Cancer Management and Research,
Год журнала:
2025,
Номер
Volume 17, С. 483 - 497
Опубликована: Март 1, 2025
To
evaluate
the
survival
outcomes
of
patients
with
intermediate
to
advanced
hepatocellular
carcinoma
(HCC),
who
underwent
transarterial
chemoembolization
(TACE)
alone
were
compared
those
a
combination
TACE
and
ablation
therapy.
This
study
retrospectively
evaluated
536
HCC
in
our
hospital
from
July
2016
November
2022.
All
TACE,
subset
also
receiving
ensure
comparability,
propensity
score
matching
(PSM)
was
performed.
We
then
overall
(OS)
progression-free
(PFS)
between
these
two
groups.
Survival
analyzed
utilizing
Kaplan-Meier
curves
via
Cox
regression.
200
among
received
combined
whereas
remaining
336
alone.
With
PFS
analysis,
numbers
reduced
176
therapy
group
250
group.
without
PSM,
OS
consistently
significantly
better
former
than
latter
In
Barcelona
Clinic
Liver
Cancer
(BCLC)
stage
B
or
C,
demonstrated
higher
treated
For
patients,
longer
group,
before
after
PSM
[hazard
ratio
(HR),
0.563;
95%
CI:
0.360-0.879;
P
=
0.012,
HR,
0.613;
0.382-0.985;
0.043].
However,
no
statistical
difference
observed
groups
for
C
(HR,
0.673;
0.395-1.146;
0.145).
Our
data
suggested
that
OS,
has
sustained
benefits
both
But
PFS,
could
not
be
persistently
by
current
datasets.
The
high
heterogeneity
of
hepatocellular
carcinoma
(HCC)
poses
challenges
for
precision
treatment
strategies.
This
study
aims
to
use
multi-omics
methodologies
better
understand
its
pathogenesis
and
discover
biomarkers.
Quantitative
proteomics
was
used
investigate
tissues
(HCT)
their
corresponding
adjacent
non-tumor
(DNT),
obtained
from
six
HCC
patients.
Untargeted
metabolomics
applied
analyze
the
metabolic
profiles
HCT
DNT
ten
Statistical
analyses,
such
as
Student's
t-test,
were
performed
identify
differentially
expressed
proteins
(DEPs)
metabolites
(DEMs)
between
two
groups.
functions
pathways
involving
DEPs
DEMs
annotated
enriched
using
gene
ontology
(GO)
kyoto
encyclopedia
genes
genomes
(KEGG)
databases.
Bioinformatics
methods
then
utilized
consistency
results,
leading
identification
potential
biomarkers
along
with
key
altered
associated
HCC.
identified
1556
samples.
These
primarily
in
crucial
biological
amino
acid
degradation,
fatty
metabolism,
DNA
replication.
Subsequently,
analysis
500
that
mainly
participated
glycerophospholipid
phospholipase
D
signaling
pathway,
choline
metabolism
related
cancer.
Integrated
data
unveiled
significant
dysfunctions
bile
secretion,
multiple
among
Further
investigation
revealed
five
(PTP4A3,
B4GALT5,
GAB1,
ME2,
PKM)
seven
(PI(6
keto-PGF1alpha/16:0),
13,
16,
19-docosatrienoic
acid,
PA(18:2(9Z,
12Z)/20:1(11Z)),
Citric
Acid,
PG(20:3(6,
8,
11)-OH(5)/18:2(9Z,
12Z)),
Spermidine,
N2-Acetylornithine)
exhibited
excellent
diagnostic
efficiency
could
serve
Our
integrated
proteome
metabolome
10
HCC-related
proposed
12
biomarkers,
which
may
enhance
our
understanding
pathophysiology
be
helpful
facilitating
early
diagnosis
Journal of Hepatocellular Carcinoma,
Год журнала:
2024,
Номер
Volume 11, С. 113 - 129
Опубликована: Янв. 1, 2024
Abstract:
Hepatocellular
carcinoma
is
the
prevailing
malignant
neoplasm
affecting
liver,
often
diagnosed
at
an
advanced
stage
and
associated
with
unfavorable
overall
prognosis.
Sorafenib
Lenvatinib
have
emerged
as
first-line
therapeutic
drugs
for
hepatocellular
carcinoma,
improving
prognosis
these
patients.
Nevertheless,
issue
of
tyrosine
kinase
inhibitor
(TKI)
resistance
poses
a
substantial
obstacle
in
management
carcinoma.
The
pathogenesis
advancement
exhibit
close
association
metabolic
reprogramming,
yet
attention
given
to
lipid
metabolism
dysregulation
development
remains
relatively
restricted.
This
review
summarizes
potential
significance
research
progress
dysfunction
Targeting
holds
promising
effective
strategy
overcome
drug
future.
Keywords:
metabolism,
sorafenib,
lenvatinib,
targeted
Metabolites,
Год журнала:
2024,
Номер
14(6), С. 325 - 325
Опубликована: Июнь 8, 2024
Epigenetic
and
metabolic
reprogramming
alterations
are
two
important
features
of
tumors,
their
reversible,
spatial,
temporal
regulation
is
a
distinctive
hallmark
carcinogenesis.
Epigenetics,
which
focuses
on
gene
regulatory
mechanisms
beyond
the
DNA
sequence,
new
entry
point
for
tumor
therapy.
Moreover,
drives
hepatocellular
carcinoma
(HCC)
initiation
progression,
highlighting
significance
metabolism
in
this
disease.
Exploring
inter-regulatory
relationship
between
epigenetic
modification
has
become
one
hot
directions
current
research.
As
viral
etiologies
have
given
way
to
dysfunction-associated
steatotic
liver
disease
(MASLD)-induced
HCC,
it
urgent
that
complex
molecular
pathways
linking
them
hepatocarcinogenesis
be
explored.
However,
how
aberrant
crosstalk
modifications
affects
MASLD-induced
HCC
lacks
comprehensive
understanding.
A
better
understanding
linkages
necessary
improve
treatment
strategies.
For
reason,
review
examines
interwoven
landscape
carcinogenesis
context
focusing
regulating
development
interactions
while
also
updating
advances
modification-based
therapeutic
drugs
HCC.
Abstract
Background
HBV
infection
is
the
leading
risk
factor
for
HCC.
has
been
confirmed
to
be
associated
with
exhaustion
status
of
CD8
+
T
cells
and
immunotherapeutic
efficacy
in
In
this
study,
we
aimed
investigate
prognostic
value
T-cell
signature
immunotherapy
response
patients
HBV-related
Methods
We
identified
different
clusters
HCC
by
single-cell
RNA
sequencing
(scRNA-seq)
exhaustion-related
genes
(TERGs)
pseudotime
analysis.
conducted
differential
expression
analysis
LASSO
Cox
regression
detect
construct
a
index
(TEI).
next
combined
TEI
other
clinicopathological
factors
design
nomogram
patients.
also
analysed
difference
between
non-responder
responder
groups
during
anti-PD-L1
therapy.
addition,
investigated
how
induces
lymphocyte
through
inhibition
tyrosine
metabolism
using
gene
set
enrichment
RT‒qPCR.
Results
A
(TEI)
was
established
5
TERGs
(EEF1E1,
GAGE1,
CHORDC1,
IKBIP
MAGOH).
An
AFP
level
>
500
ng,
vascular
invasion,
histologic
grade
(G3-G4),
advanced
TNM
stage
poor
five-year
prognosis
were
related
higher
score,
while
lower
score.
Among
those
receiving
therapy,
responders
had
TEIs
than
non-responders
did.
The
serves
as
an
independent
HCC,
incorporating
TEI,
stage,
invasion
exhibited
excellent
predictive
RT‒qPCR
revealed
that
among
metabolism-associated
genes,
TAT
(tyrosine
aminotransferase)
HGD
(homogentisate
1,2
dioxygenase)
expressed
at
levels
HBV-HCC
non-HBV
Conclusion
Generally,
novel
model
comprehensively
analysing
progression
exhaustion,
which
shows
promise
predicting
clinical
potential
Metabolites,
Год журнала:
2023,
Номер
13(10), С. 1047 - 1047
Опубликована: Окт. 2, 2023
Hepatocellular
carcinoma
(HCC),
the
most
prevalent
form
of
liver
cancer,
is
third
leading
cause
mortality
globally.
Patients
with
HCC
have
a
poor
prognosis
due
to
fact
that
emergence
symptoms
typically
occurs
at
late
stage
disease.
In
addition,
conventional
biomarkers
perform
suboptimally
when
identifying
in
its
early
stages,
heightening
need
for
identification
new
and
more
effective
biomarkers.
Using
metabolomics
lipidomics
approaches,
this
study
aims
identify
serum
patients
cirrhosis
(LC).
Serum
samples
from
20
cases
LC
were
analyzed
using
ultra-high-performance
liquid
chromatography-Q
Exactive
mass
spectrometry
(UHPLC-Q-Exactive-MS).
Metabolites
lipids
are
significantly
altered
between
identified.
These
include
organic
acids,
amino
TCA
cycle
intermediates,
fatty
bile
glycerophospholipids,
sphingolipids,
glycerolipids.
The
significant
variability
was
observed
concentrations
glycerophospholipids.
context
cases,
there
notable
increase
levels
phosphatidylethanolamine
triglycerides,
but
acids
phosphatidylcholine
exhibited
substantial
decrease.
it
all
identified
metabolites
superior
area
under
receiver
operating
characteristic
(ROC)
curve
comparison
alpha-fetoprotein
(AFP).
pathway
analysis
these
revealed
acid,
lipid,
energy
metabolism
as
impacted
pathways.
Putative
will
be
validated
future
studies
via
targeted
quantification.
