Pharmaceuticals, Год журнала: 2024, Номер 17(1), С. 126 - 126
Опубликована: Янв. 18, 2024
Resveratrol is a polyphenolic compound that has gained considerable attention in the past decade due to its multifaceted therapeutic potential, including anti-inflammatory and anticancer properties. However, efficacy impeded by low water solubility, dose-limiting toxicity, bioavailability, rapid hepatic metabolism. To overcome these hurdles, various nanoparticles such as organic inorganic nanoparticles, liposomes, polymeric dendrimers, solid lipid gold zinc oxide zeolitic imidazolate frameworks, carbon nanotubes, bioactive glass mesoporous were employed deliver resveratrol, enhancing against types of cancer. Resveratrol-loaded nanoparticle or resveratrol-conjugated administration exhibits excellent potency compared free resveratrol. This review highlights latest developments nanoparticle-based delivery systems for focusing on potential limitations associated with compound’s bioavailability effectiveness.
Язык: Английский
Процитировано
21Natural Compounds for Preventing Age-Related Diseases and Cancers
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7530 - 7530
Опубликована: Июль 9, 2024
Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.
Язык: Английский
Процитировано
8Phytoconstituents of Kenyan stinging nettle (Urtica species) and their molecular docking interactions revealed anti-inflammatory potential as cyclooxygenase-2 inhibitors
Scientific African, Год журнала: 2024, Номер 23, С. e02088 - e02088
Опубликована: Янв. 20, 2024
Inflammation is a complex, natural protective response towards different stimuli characterized by the dilation and permeation of blood vessels with surge in leukocytes tissues. The current treatment involves use anti-inflammatory drugs, corticosteroids non-steroidal drugs (NSAIDs), which have been associated adverse side effects especially gastrointestinal ulcers. Therefore, there growing need to explore alternative sources from medicinal plants. In present study we investigated activities leaves Kenyan stinging nettle using vivo silico molecular docking. Molecular identification plant sample was carried out based on DNA barcoding. Crude extracts were prepared water methanol: dichloromethane (1:1) preliminary total phenolic flavonoids Folin-Ciocalteu aluminium chloride colorimetric methods, respectively. classical model Carrageenan- induced paw edema used test activity extracts. extract screened Raman Spectroscopy Liquid Chromatography Mass (LC-MS) interaction between identified compounds within binding site Cyclooxygenase-2 (COX-2) performed through docking as confirmatory tool experiments. Based barcoding analysis, Urtica species. content aqueous 3.75 mg gallic acid equivalents (GAE)/g dry 6.26 GAE/g while flavonoid 0.3872 quercetin/g 1.76 sample, significantly (p < 0.05) reduced Carrageenan inflammation. LC-MS confirmed presence 19 phytochemicals, 10 9 compounds, From these quercetin attained lowest energy when complexed COX-2, followed rhamnetin, rhamnoside, epigallocatechin gallate chlorogenic acid. studies supported findings potential sp. These suggest source bioactive that could be employed future development anti-inflammation drugs. Further can attempt assess individual isolated active compound(s) for their activity.
Язык: Английский
Процитировано
4In silico evaluation of potential breast cancer receptor antagonists from GC-MS and HPLC identified compounds in Pleurotus ostreatus extracts
RSC Advances, Год журнала: 2024, Номер 14(33), С. 23744 - 23771
Опубликована: Янв. 1, 2024
Introduction: Pharmacotherapeutic targets for breast cancer include the estrogen receptor (ER), progesterone (PR), and human epidermal growth factor (EGFR). Inhibitors of these receptors could be interesting therapeutic candidates treatment management (BC). Aim: This study used GC-MS HPLC to identify bioactive compounds in Pleurotus ostreatus (P. ostreatus) extracts applied silico methods potent EGFR, ER, PR inhibitors from as potential drug candidates. Method: were chemicals P. aqueous (PO-A), methanol (PO-M), ethanol (PO-E), chloroform (PO-C), n-hexane (PO-H). The PR, EGFR model optimization molecular docking compounds/control binding pocket simulated using AutoDock Vina PyRx. drug-likeness, pharmacokinetic, pharmacodynamic features prospective leads all anticipated. Result: results indicated existence 29 PO-A, 36 PO-M PO-E, 42 PO-C, 22 PO-H extracts. With only o-tolylamino-acetic acid (4-nitro-benzylidene)-hydrazide (-7.5 kcal mol-1) ethanolic extract bind receptor. on other hand, identified several with higher affinities than control. Ergotaman-3',6',18-trione (-8.1 mol-1), 5,10-diethoxy-2,3,7,8-tetrahydro-1H,6H-dipyrrolo[1,2-a:1',2'-d]pyrazine (-7.8 extract; (-8.4 had better affinity compared (-7.7 mol-1). Likewise, ergotaman-3',6',18-trione (-9.7 phenol, 2,4-bis(1,1-dimethyl ethyl) (-8.2 control, gefitinib (-7.9 regards EGFR. None or outperformed control any proteins. Phenols flavonoids such quercetin, luteolin, rutin, chrysin, apigenin, ellagic acid, naringenin their Conclusion: class phenols lead molecules due ability strongly proteins' receptors. These showed promising drug-like properties; they safe new creating anticancer medicines.
Язык: Английский
Процитировано
4Sustainable Strategies for Cancer Phytomedicine: Balancing Efficacy and the Environment Responsibility
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Structure modification of luteolin and the influence of its derivatives on biological activities
Frontiers in Nutrition, Год журнала: 2025, Номер 12
Опубликована: Март 12, 2025
Introduction This research aims to synthesize luteolin derivatives from hemp seeds by means of chemical synthesis, improve the synthesis process, simplify procedure, and increase yield obtain new derivatives. Additionally, anti-inflammatory antioxidant activities seed extracts newly synthesized substances are tested screen out with high activities. Methods Using as raw material, acetyl, propionyl, butyryl groups introduced into molecular structure luteolin. A one-pot method is employed modify hydroxyl at positions 5, 7, 3′, 4′ six acyl The molar ratio reaction conditions 1:4. Pyridine (20 mL) used solvent, carried 25°C 110°C. Exploring its establishing a psoriasis model. Results products separated purified column chromatography recrystallization, were synthesized: namely, 7,3′,4′-tri-O-acetylated (A), 7,3′,4′-tri-O-propionylated (B), 7,3′,4′-tri-O-butyrylated (C), 5,7,3′,4′-tetra-O-acetylated (D), 5,7,3′,4′-tetra-O-propionylated (E), 5,7,3′,4′-tetra-O-butyrylated (F). By like mouse model, results showed that have good therapeutic effects on inflammation antioxidation. Discussion Six through structural modification, which improved their solubility bioavailability. In psoriasismodel, it has been proven activities, relieving effect psoriasis.Provide theoretical basis potential treatment strategies for future psoriasis.
Язык: Английский
Процитировано
0Dietary phytochemical index and the risk of cancer: A systematic review and meta-analysis
PLoS ONE, Год журнала: 2025, Номер 20(4), С. e0319591 - e0319591
Опубликована: Апрель 2, 2025
Background Recently, the association between dietary phytochemical index (DPI) and risk of cancer has been focus researchers, however, this possible not fully understood. The current meta-analysis aimed to assess relationship DPI cancers. Methods A literature search by main keywords such as “dietary index”, “DPI”, “cancer” was completed using Scopus, PubMed, Web Science up December 2024 references retrieved relevant articles. Observational studies examining cancers were included. reported odds ratio (OR) with a 95% confidence interval (CI) for each study converted into log OR, their standard deviation calculated. Then compute pooled random-effects model inverse variance weighting method performed. Results Nine case-control included in present meta-analysis. sample size ranged from 120 851 an age range 18 75 years. results indicate all (OR: 0.40; CI: 0.29–0.54, I 2 = 0.00%; P-value < 0.001). Also, subgroup analysis indicated that higher score is related decreased breast 0.38; 0.26–0.55, 0.001) non-breast including glioma, prostate, colorectal 0.43; 0.27–0.71, Conclusions revealed associated Large-scale cohort are recommended validate findings presented study.
Язык: Английский
Процитировано
0Harnessing Nature's Potential: Exploring Phytoestrogens in Cervical Cancer
Phytomedicine Plus, Год журнала: 2025, Номер unknown, С. 100796 - 100796
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0Immunomodulatory activity of bamboo biosilica from Dendrocalamus longispathus Kurz. – Metabolomics integrated network pharmacology approach
Phytomedicine, Год журнала: 2025, Номер unknown, С. 156797 - 156797
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0Heliotropium curassavicum extract: Potential therapeutic agent for liver cancer through cytotoxicity, apoptosis, and molecular docking analysis
Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(10), С. 105986 - 105986
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
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