Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Probiotics
are
live
microorganisms
believed
to
confer
health
benefits
when
consumed
appropriately.
Prebiotics
non-digestible
food
components
that
promote
by
encouraging
the
growth
or
activity
of
beneficial
microorganisms.
Synbiotics
a
combination
probiotics
and
prebiotics.
This
study
aimed
assess
knowledge
awareness
Palestinian
healthcare
professionals
regarding
probiotics,
prebiotics,
synbiotics.
A
cross-sectional
was
conducted
across
West
Bank
using
structured
questionnaire,
descriptive
analysis
performed
SPSS.
The
results
indicated
68.5%
physicians
83.4%
pharmacists
were
aware
whereas
only
37%
48%
had
Awareness
synbiotics
even
lower,
with
20%
26.6%
reporting
familiarity.
These
findings
suggest
while
there
is
reasonable
level
about
prebiotics
significantly
lacking,
which
limits
their
use.
Enhancing
these
products
could
be
facilitated
through
workshops,
ongoing
education,
involvement
medical
representatives.
Genes Brain & Behavior,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 13, 2025
ABSTRACT
Human
microbiota‐associated
murine
models,
using
fecal
microbiota
transplantation
(FMT)
from
human
donors,
help
explore
the
microbiome's
role
in
diseases
like
Alzheimer's
disease
(AD).
This
study
examines
how
gut
bacteria
donors
with
protective
factors
against
AD
influence
behavior
and
brain
pathology
an
mouse
model.
Female
3xTgAD
mice
received
weekly
FMT
for
2
months
(i)
80‐year‐old
patient
(AD‐FMT),
(ii)
a
cognitively
healthy
73‐year‐old
APOEe2
allele
(APOEe2‐FMT),
(iii)
22‐year‐old
donor
(Young‐FMT),
(iv)
untreated
(Mice‐FMT).
Behavioral
assessments
included
novel
object
recognition
(NOR),
Y‐maze,
open‐field,
elevated
plus
maze
tests;
(amyloid
tau),
neuroinflammation
(in
situ
autoradiography
of
18
kDa
translocator
protein
hippocampus);
were
analyzed.
APOEe2‐FMT
improved
short‐term
memory
NOR
test
compared
to
AD‐FMT,
without
significant
changes
other
behavioral
tests.
was
associated
increased
hippocampus,
but
no
effect
detected
on
amyloidosis
tauopathy.
Specific
genera,
such
as
Parabacteroides
Prevotellaceae_UGC001
,
enriched
group
neuroinflammation,
while
genera
Desulfovibrio
reduced
linked
decreased
neuroinflammation.
Gut
factor
induced
regions
strategic
AD.
The
association
several
suggests
collegial
transplanted
microbiome
rather
than
single‐microbe
driver
effect.
These
data
support
between
bacteria,
glial
cell
activation,
cognitive
function
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 163 - 163
Опубликована: Янв. 22, 2025
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
correlated
with
an
increased
cardiovascular
risk,
independent
of
other
traditional
risk
factors.
The
mechanisms
underlying
this
pathogenic
link
are
complex
yet
remain
incompletely
elucidated.
Among
these,
the
most
significant
visceral
adiposity,
low-grade
inflammation
and
oxidative
stress,
endothelial
dysfunction,
prothrombotic
status,
insulin
resistance,
dyslipidemia
postprandial
hyperlipemia,
gut
dysbiosis,
genetic
mutations.
Cardiovascular
diseases
leading
cause
death
in
patients
MASLD.
These
have
incidence
coronary
artery
disease,
carotid
structural
functional
cardiac
abnormalities,
valvulopathies,
as
well
arrhythmias
conduction
disorders.
In
review,
we
present
latest
data
on
association
between
MASLD
focusing
that
explain
correlation
these
two
pathologies.
Given
high
rates
morbidity
mortality
among
MASLD,
consider
it
imperative
to
raise
awareness
risks
associated
condition
within
general
population.
Further
research
essential
clarify
linked
This
understanding
may
facilitate
identification
new
diagnostic
prognostic
biomarkers
for
patients,
novel
therapeutic
targets.
Arterial’naya Gipertenziya (Arterial Hypertension),
Год журнала:
2025,
Номер
30(5), С. 451 - 466
Опубликована: Янв. 21, 2025
Objective
.
To
study
modern
ideas
about
the
influence
of
intestinal
microbiome,
oral
cavity
and
atherosclerotic
plaque
on
development
progression
atherosclerosis
(AS).
Design
methods
The
literature
review
was
carried
out
by
analyzing
scientific
publications
in
PubMed,
meta-analyses,
randomized
clinical
trials,
as
well
guidelines
articles
within
period
from
1997
to
2024.
This
examines
above-mentioned
non-traditional
risk
factors
(RF)
for
AS.
Conclusions
AS
is
a
disease
with
multifactorial
pathogenesis.
Understanding
role
both
classical
non-classical
RF
vascular
important
effective
preventive
therapeutic
measures.
Among
microbiome.
fundamental
mechanisms
microbiota
intestines
include
following:
direct
damaging
effect
lipopolysaccharides
bacterial
toxins
wall,
microbial
metabolites
increased
permeability
wall
translocation
into
systemic
bloodstream,
chronic
lowlevel
inflammation
endothelial
dysfunction.
abovedescribed
Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Probiotics
are
live
microorganisms
believed
to
confer
health
benefits
when
consumed
appropriately.
Prebiotics
non-digestible
food
components
that
promote
by
encouraging
the
growth
or
activity
of
beneficial
microorganisms.
Synbiotics
a
combination
probiotics
and
prebiotics.
This
study
aimed
assess
knowledge
awareness
Palestinian
healthcare
professionals
regarding
probiotics,
prebiotics,
synbiotics.
A
cross-sectional
was
conducted
across
West
Bank
using
structured
questionnaire,
descriptive
analysis
performed
SPSS.
The
results
indicated
68.5%
physicians
83.4%
pharmacists
were
aware
whereas
only
37%
48%
had
Awareness
synbiotics
even
lower,
with
20%
26.6%
reporting
familiarity.
These
findings
suggest
while
there
is
reasonable
level
about
prebiotics
significantly
lacking,
which
limits
their
use.
Enhancing
these
products
could
be
facilitated
through
workshops,
ongoing
education,
involvement
medical
representatives.
