Journal of Food Science,
Год журнала:
2024,
Номер
89(9), С. 5858 - 5869
Опубликована: Июль 23, 2024
Abstract
Our
previous
studies
have
shown
that
sulfated
Cyclocarya
paliurus
polysaccharides
(SCP3)
can
alleviate
intestinal
oxidative
stress
(OS)
damage
by
improving
the
antioxidant
capacity
of
intestine,
but
its
mechanism
still
needs
further
exploration.
This
study
aimed
to
reveal
possible
underlying
protective
SCP3
against
OS
epithelial
cells
(IEC‐6)
based
on
transcriptome
profiling.
The
results
showed
could
increase
activity
superoxide
dismutase
and
reduce
production
malondialdehyde
reactive
oxygen
species.
In
addition,
also
H
2
O
‐induced
high
apoptosis
rate
mitochondrial
membrane
potential
decrease
in
IEC‐6
cells.
RNA‐sequencing
there
were
2152
differentially
expressed
genes
between
control
group
group,
mitogen‐activated
protein
kinases
(MAPK)
PI3K‐Akt
signaling
pathways
are
main
contributed
protecting
from
damage.
summary,
plays
a
role
cell
inhibiting
OS,
which
may
be
closely
related
PI3K/Akt
MAPK
pathways.
Practical
Application
provides
theoretical
basis
for
practical
application
as
an
ingredient
auxiliary
medicines
functional
foods.
Due
to
the
complex
pathophysiological
mechanisms
involved
in
cancer
progression
and
metastasis,
current
therapeutic
approaches
lack
efficacy
have
significant
adverse
effects.
Therefore,
it
is
essential
establish
novel
strategies
for
combating
cancer.
Phytochemicals,
which
possess
multiple
biological
activities,
such
as
antioxidant,
anti-inflammatory,
antimutagenic,
immunomodulatory,
antiproliferative,
anti-angiogenesis,
antimetastatic
properties,
can
regulate
interfere
various
stages
of
development
by
suppressing
signaling
pathways.
The
systematic
comprehensive
review
was
conducted
based
on
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analysis
(PRISMA)
criteria,
using
electronic
databases,
including
PubMed,
Scopus,
Science
Direct,
until
end
December
2023.
After
excluding
unrelated
articles,
111
related
articles
were
included
this
review.
In
review,
major
pathways
metabolism
are
highlighted
with
promising
anticancer
role
phytochemicals.
This
through
their
ability
AMP-activated
protein
kinase
(AMPK)/peroxisome
proliferator-activated
receptor-gamma
coactivator-1α
(PGC-1α)
pathway.
AMPK/PGC-1α
pathway
plays
a
crucial
cell
via
targeting
energy
homeostasis
mitochondria
biogenesis,
glucose
oxidation,
fatty
acid
thereby
generating
ATP
growth.
As
result,
may
represent
approach
treatment.
Accordingly,
alkaloids,
phenolic
compounds,
terpene/terpenoids,
miscellaneous
phytochemicals
been
introduced
agents
regulating
Novel
delivery
systems
also
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 352 - 352
Опубликована: Март 18, 2025
(1)
Background:
Glucuronolactone
(GLU)
is
a
glucose
metabolite
with
antioxidant
activity.
At
present,
the
exact
role
of
it
in
regulating
intestinal
health
piglets
under
weaning
stress
not
clear.
The
purpose
this
study
to
investigate
effects
GLU
on
growth
performance
and
explore
potential
mechanisms.
(2)
Methods:
Twenty-four
weaned
were
randomly
assigned
into
two
groups,
one
group
receiving
basal
diet
other
an
experimental
supplemented
200
mg/kg
GLU.
(3)
Results:
increased
ADG,
ADFI,
final
body
weight
piglets,
while
reducing
diarrhea
rate.
Mechanistically,
alleviates
stress-induced
oxidative
inflammatory
responses
partly
through
activating
Nrf2-Akt
signaling
pathway
suppress
transcriptional
activity
FOXO1,
also
inhibiting
activation
TLR4-MAPK
reduce
secretion
pro-inflammatory
cytokines.
Moreover,
relative
abundance
Lactobacillus
reuteri
ileum
improved
composition
gut
microbiota.
(4)
Conclusions:
reduced
inflammation
Nrf2/Akt/FOXO1
health,
resulting
piglets.
Poultry Science,
Год журнала:
2025,
Номер
unknown, С. 105140 - 105140
Опубликована: Апрель 1, 2025
The
rising
prevalence
of
heat
stress
(HS),
because
global
warming,
presents
a
considerable
challenge
to
both
human
and
animal
health
welfare.
L-Theanine
(LTA),
naturally
occurring
amino
acid,
may
enhance
poultry
muscle
yield
quality,
suggesting
its
potential
application
in
alleviating
the
negative
impacts
HS.
However,
molecular
mechanisms
through
which
LTA
exerts
beneficial
effects
remain
be
fully
understood.
This
study
explored
protective
on
cultured
broiler
skeletal
cells
under
oxidative
induced
by
HS,
focusing
involved.
Our
findings
indicate
that
treatment
with
significantly
improved
cell
survival,
bolstered
activity
antioxidant
enzymes,
decreased
reactive
oxygen
species
(ROS)
contents
diminished
malondialdehyde
(MDA)
levels
HS-treated
cells.
Furthermore,
enhanced
phosphatidylinositol
3-kinase
(PI3K)/protein
kinase
B
(AKT)
nuclear
factor
erythroid
2-related
2
(Nrf2)
signaling
pathways
cells,
facilitating
mitochondrial
biogenesis
reducing
apoptosis.
were
reduced
PI3K
inhibitor
LY294002
or
Nrf2
ML385.
In
conclusion,
our
showed
protects
from
HS-induced
damage
modulating
PI3K/AKT/Nrf2
pathway,
positioning
as
promising
natural
for
feed
additives
aimed
at
improving
health.
Antioxidants,
Год журнала:
2023,
Номер
12(12), С. 2078 - 2078
Опубликована: Дек. 6, 2023
The
accumulation
of
oxidative
stress
is
one
the
important
factors
causing
cellular
senescence.
Oxymatrine
(OM)
a
natural
quinolizidine
alkaloid
compound
known
for
its
antioxidant
effects.
This
study
aimed
to
investigate
anti-senescence
potential
OM
through
stress-induced
in
vitro
and
vivo
models.
By
treating
600
μM
H2O2
HT22
mouse
hippocampal
neuronal
cell
line
by
administering
150
mg/kg
D-galactose
mice,
we
generated
senescence
After
providing
1,
2,
4
μg/mL
50
evaluated
enhancing
We
different
markers,
AMPK
activity,
autophagy,
along
with
DCFH-DA
detection
reaction
behavioral
tests.
In
cells,
showed
protective
effect.
OM,
reducing
ROS
increasing
p-AMPK
expression,
could
potentially
reduce
D-Gal-induced
model,
both
brain
heart
tissues
recovered
resulting
reduced
levels
neural
tissue,
assess
neurological
recovery,
including
anxiety
symptoms
exploration,
used
test.
also
found
that
decreased
expression
level
receptors
advanced
glycation
end
products
(RAGE).
observe
restoration
which
increased
activity
autophagy.
results
our
suggest
ameliorates
action
restoring
activity.
