Herbal
medicines
are
the
obtained
from
plant
sources.
This
is
an
alternate
type
of
treatment
based
on
traditional
knowledge
and
scientific
evidences
in
many
cases.
The
utility
plants
as
whole
or
their
parts
like
fruits,
flowers,
leaves,
stem,
roots
have
been
established
for
diseases.
active
ingredients
present
either
alone
combination
improved
immune
system
if
taken
with
proper
care.
Many
studies
shown
that
these
better
comparison
to
conventional
modern
respect
less
no
side
effects.
chapter
focused
use
herbal
boosting
system.
covers
why
people
prefer
medicines,
role
some
enhancing
system,
individual
natural
products
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 31, 2024
Rheumatoid
arthritis
is
a
chronic
immunological
disease
leading
to
the
progressive
bone
and
joint
destruction.
Angiogenesis,
accompanied
by
synovial
hyperplasia
inflammation
underlies
Delaying
or
even
blocking
angiogenesis
has
emerged
as
an
important
target
of
RA
treatment.
Natural
medicines
long
history
treating
RA,
numerous
reports
have
suggested
that
natural
strong
inhibitory
activity
on
angiogenesis,
thereby
improving
progression
RA.
could
regulate
following
signaling
pathways:
HIF/VEGF/ANG,
PI3K/Akt
pathway,
MAPKs
NF-κB
PPARγ
JAK2/STAT3
etc.,
inhibiting
angiogenesis.
Tripterygium
wilfordii
Hook.
f.
(TwHF),
sinomenine,
total
glucoside
Paeonia
lactiflora
Pall.
Are
currently
most
representative
all
products
worthy
development
utilization.
In
this
paper,
main
factors
affecting
were
discussed
different
types
inhibit
systematically
summarized.
Their
specific
anti-angiogenesis
mechanisms
are
also
reviewed
which
aiming
provide
new
perspective
options
for
management
targeting
Archiv der Pharmazie,
Год журнала:
2024,
Номер
358(1)
Опубликована: Ноя. 14, 2024
Abstract
This
study
deals
with
the
comprehensive
phytochemical
composition
and
antiviral
activity
against
SARS‐CoV‐2
of
acidic
(non‐decarboxylated)
neutral
(decarboxylated)
ethanolic
extracts
from
seven
high‐cannabidiol
(CBD)
two
high‐Δ
9
‐tetrahydrocannabinol
(Δ
‐THC)
Cannabis
sativa
L.
genotypes.
Their
secondary
metabolite
profiles,
phytocannabinoid,
terpenoid,
phenolic,
were
determined
by
LC‐UV,
GC‐MS,
LC‐MS/MS
analyses,
respectively.
All
three
cannabinoid,
varied
significantly
among
cannabinoid
different
The
dose–response
analyses
their
showed
that
only
single
predominant
phytocannabinoids
(CBD
or
THC)
exhibited
(all
IC
50
<
10.0
μM).
correlation
matrix
between
phytoconstituent
levels
revealed
phenolic
acids,
salicylic
acid
its
glucoside,
chlorogenic
acid,
ferulic
flavonoids,
abietin,
luteolin,
in
high‐CBD
genotypes
are
implicated
genotype‐distinct
antagonistic
effects
on
phytocannabinoid.
On
other
hand,
these
also
suggested
flavonoid
orientin
can
enrich
extract's
pharmacological
profiles.
Thus,
further
preclinical
studies
extract
formulations
adjusted
non‐phytocannabinoid
compositions
warranted
to
develop
supplementary
treatments.
Expert Opinion on Drug Discovery,
Год журнала:
2024,
Номер
19(9), С. 1023 - 1041
Опубликована: Июль 30, 2024
Introduction
Highly
pathogenic
coronaviruses
(CoVs),
such
as
severe
acute
respiratory
syndrome
CoV
(SARS-CoV),
Middle
East
(MERS-CoV),
and
the
most
recent
SARS-CoV-2
responsible
for
COVID-19
pandemic,
pose
significant
threats
to
human
populations
over
past
two
decades.
These
CoVs
have
caused
a
broad
spectrum
of
clinical
manifestations
ranging
from
asymptomatic
distress
syndromes
(ARDS),
resulting
in
high
morbidity
mortality.
Phytochemical Analysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 13, 2024
This
study
evaluates
the
effectiveness
of
Traditional
Chinese
Medicine
(TCM)
extracts
in
blocking
interaction
between
SARS-CoV-2
Spike
protein
and
human
ACE2
receptor,
utilizing
a
dual-method
approach
to
explore
antiviral
potential
natural
compounds.
Molecules,
Год журнала:
2023,
Номер
28(13), С. 5210 - 5210
Опубликована: Июль 4, 2023
Ulcerative
colitis
(UC)
is
a
chronic,
non-specific
disease
of
unknown
etiology.
The
develops
mainly
in
the
rectum
or
colon,
and
main
clinical
symptoms
include
abdominal
pain,
diarrhea,
purulent
bloody
stools,
with
wide
variation
severity.
specific
causative
factors
pathogenesis
are
not
yet
clear,
but
most
scholars
believe
that
caused
by
interaction
genetic,
environmental,
infectious,
immune,
intestinal
flora
factors.
As
for
treatment
UC,
medications
commonly
used
practice,
including
aminosalicylates,
glucocorticoids,
immunosuppressive
drugs.
However,
due
to
many
complications
associated
conventional
drug
therapy
tendency
UC
recur,
there
an
urgent
need
discover
new,
safer,
more
effective
Natural
compounds
biodiversity
chemical
structure
diversity
from
medicinal
plants
reliable
source
development
new
precursors.
Evidence
suggests
glycosides
may
reduce
progression
modulating
anti-inflammatory
responses,
inhibiting
oxidative
stress,
suppressing
abnormal
immune
regulating
signal
transduction.
In
this
manuscript,
we
provide
review
epidemiology
available
drugs
prevention
treatment.
addition,
demonstrate
protective
therapeutic
role
describe
possible
mechanisms
action
theoretical
basis
preclinical
studies
development.
Diseases,
Год журнала:
2023,
Номер
11(3), С. 105 - 105
Опубликована: Авг. 9, 2023
The
need
for
effective
therapeutic
regimens
non-critically
ill
patients
during
the
COVID-19
pandemic
remained
largely
unmet.
Previous
work
has
shown
that
a
combination
of
three
aromatic
plants'
essential
oils
(CAPeo)
(Thymbra
capitata
(L.)
Cav.,
Origanum
dictamnus
L.,
Salvia
fruticose
Mill.)
remarkable
in
vitro
antiviral
activity.
Given
its
properties,
it
was
urgent
to
explore
potential
treating
mild
primary
care
settings.A
total
69
adult
were
included
clinical
proof-of-concept
(PoC)
intervention
study.
Family
physicians
implemented
observational
study
two
arms
(intervention
group
and
control
group)
periods
(IG2020,
n=13,
IG2021/22,
n=25,
CG2021/22,
n=31).
SARS-CoV-2
infection
confirmed
by
real-time
PCR.
CAPeo
mixture
administered
daily
14
days
per
os
group,
while
received
usual
care.The
PoC
found
number
frequency
general
symptoms,
including
fatigue,
weakness,
fever,
myalgia,
decreased
following
administration.
By
Day
7,
average
presence
(number)
symptoms
comparison
with
1
IG
(4.7
1.4)
as
well
CG
(4.0
3.1),
representing
significant
decrease
cumulative
IC
(-3.3
vs.
-0.9,
p
<
0.001;
η2
=
0.20)
on
7
(-4.2
-2.9,
0.027;
0.08).Our
findings
suggest
possesses
potent
activity
against
addition
tο
effect
influenza
A
B
human
rhinovirus
HRV14
strains.
early
impact
alleviating
key
may
this
can
act
complementary
natural
agent
COVID-19.
