Relationship between Disease Characteristics and Circulating Interleukin 6 in a Well-Characterized Cohort of Patients with Systemic Lupus Erythematosus
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(18), С. 14006 - 14006
Опубликована: Сен. 12, 2023
Interleukin-6
(IL-6)
is
a
proinflammatory
cytokine
that
mediates
pleiotropic
functions
in
immune
responses
and
inflammatory
diseases.
The
literature
lacks
studies,
with
clinical
perspective,
on
the
relationship
between
IL-6
serum
levels
characteristics
of
disease
patients
systemic
lupus
erythematosus
(SLE).
In
present
work,
we
aimed
to
analyze
association
circulating
manifestations
well-characterized
series
SLE.
Serum
activity
(SLEDAI-2K),
severity
(Katz)
damage
index
(SLICC-DI),
complete
lipid
profile,
subclinical
carotid
atherosclerosis
were
evaluated
284
addition,
characterization
complement
system
was
performed
samples
from
A
multivariate
linear
regression
analysis
carried
out
study
laboratory
levels.
Age
(beta
coef.
0.07
[95%CI
0.01–0.1]
pg/mL,
p
=
0.014),
C-reactive
protein
0.21
0.16–0.25]
<
0.01),
male
gender
2
0.3–0.5]
0.024),
positively
associated
higher
SLE
patients.
Most
indices
did
not
show
significant
relationships
IL-6.
However,
after
analysis,
lower
HDL
cholesterol
−0.04
−0.08–(−0.1)]
0.011),
apolipoprotein
A1
−0.02
−0.04–(−0.001)]
0.035).
contrast,
alternative
cascade,
C1inh,
C3a
all
independently
Moreover,
stratification
Systematic
Coronary
Risk
Assessment
(SCORE2)
results
according
different
categories
cardiovascular
risk
0.2
0.02–0.4],
0.028).
conclusion,
large
patients,
disease-related
features
SLE,
including
damage,
severity,
or
indices.
an
found
risk.
Our
emphasizes
importance
could
have
disruption
Therapies
targeting
role
these
two
Язык: Английский
Deciphering the Reactivity of Autoantibodies Directed against the RNP-A, -C and 70 kDa Components of the U1-snRNP Complex: “Double or Nothing”?
Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1552 - 1552
Опубликована: Июль 12, 2024
Background:
The
positivity
of
anti-RNP
autoantibodies
as
biological
criteria
for
the
diagnosis
mixed
connective
tissue
disease
(MCTD)
has
recently
divided
rheumatology
community.
Autoantigenicity
U1-snRNP
complex
tends
to
generate
multiple
against
RNP-A,
-C
and
-70
KDa
or
Sm
proteins.
aim
this
study
is
identify
most
informative
in
clinical
practice,
particular,
contribute
differential
between
MCTD
systemic
lupus
erythematosus
(SLE).
Methods:
Sera
from
74
patients
positive
were
selected
over
a
period
one
year
laboratory
practice.
Autoantibodies
directed
extractable
nuclear
antigen,
RNP
proteins
(A,
C,
70
KDa)
40
kDa
fragments
RNP-70
investigated
by
using
quantitative
fluoroenzymatic
assay
Western
blot
analysis.
Results:
Among
patients,
diagnosed
with
SLE,
20
MCTD,
six
another
autoimmune
disease,
three
SARS-CoV-2
infection,
cancer
two
healthy.
No
preferential
association
IgG
IgM
each
was
found
SLE
MCTD.
In
contrast,
proportion
component
within
showed
significantly
higher
index
than
those
(p
=
0.011),
good
performance
(sensitivity:
69.2%,
specificity:
88.9%).
Conclusions:
analysis
different
more
autoantibody
separately.
A
follow-up
could
be
about
interest
predictor
evolution.
Язык: Английский