International journal for autism challenges & solution.,
Год журнала:
2024,
Номер
1(1), С. 91 - 104
Опубликована: Дек. 30, 2024
Oxytocin
(OXT)
is
a
neuropeptide
implicated
in
social
functioning,
with
potential
therapeutic
relevance
autism
spectrum
disorder
(ASD).
This
review
synthesizes
current
literature
on
OXT's
effects
ASD,
focusing
clinical
trials,
neurobiological
mechanisms,
and
future
directions.
Studies
highlight
immediate
impact
cognition
typically
developing
adults
its
variable
outcomes
children
ASD.
Neuroimaging
findings
elucidate
brain
networks
involved
social-emotional
processing.
Challenges,
including
individual
variability
translational
gaps,
underscore
the
crucial
role
of
personalized
approaches
OXT
research.
Combining
behavior
therapy
probiotics
shows
promise.
Future
research
should
address
gender
differences,
genetic
influences,
long-term
outcomes,
emphasizing
importance
OXT-based
therapies.
Heliyon,
Год журнала:
2024,
Номер
10(4), С. e25761 - e25761
Опубликована: Фев. 1, 2024
Oxytocin
acts
through
the
oxytocin
receptor
(OXTR)
to
modulate
uterine
contractility.
We
previously
identified
OXTR
genetic
variants
and
showed
that,
in
HEK293T
cells,
two
of
protein
localized
cell
surface
less
than
wild-type
OXTR.
Here,
we
sought
measure
more
native
human
myometrial
smooth
muscle
(HMSMC)
line
on
both
cell-surface
across
whole
cell,
used
CRISPR
editing
add
an
HA
tag
endogenous
gene
for
anti-HA
measurement.
Quantitative
flow
cytometry
revealed
that
these
cells
possessed
55,000
±
3200
total
OXTRs
4900
390
per
cell.
To
identify
any
differential
versus
variant
localization,
transiently
transfected
HMSMCs
exogenously
express
or
with
green
fluorescent
tags.
Total
expression
all
tested
were
similar.
However,
lower
localization
also
presented
HMSMCs.
Overall,
confirm
a
type,
further
demonstrate
quantitative
technique
is
adaptable
whole-cell
measurements.
Journal of Neurochemistry,
Год журнала:
2025,
Номер
169(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Stress,
an
evolutionarily
adaptive
mechanism,
has
become
a
pervasive
challenge
in
modern
life,
significantly
impacting
feeding‐relevant
circuits
that
play
role
the
development
and
pathogenesis
of
eating
disorders
(EDs).
Stress
activates
hypothalamic–pituitary–adrenal
(HPA)
axis,
disrupts
specific
neural
circuits,
dysregulates
key
brain
regions,
including
hypothalamus,
hippocampus,
lateral
septum.
These
particular
structures
are
interconnected
integrating
stress
feeding
signals,
modulating
hunger,
satiety,
cognition,
emotional
coping
behaviors.
Here
we
discuss
interplay
between
genetic
predispositions
environmental
factors
may
exacerbate
ED
vulnerability.
We
also
highlight
most
commonly
used
animal
models
to
study
mechanisms
driving
EDs
recent
rodent
studies
emphasize
discovery
novel
cellular
molecular
signals
within
hippocampus–lateral
septum–hypothalamus
axis.
In
this
review,
gut
microbiome,
emerging
area
research
field
unanswered
questions
persist
hinder
scientific
progress,
such
as
why
some
individuals
remain
resilient
while
others
at
high
risk
for
EDs.
finally
need
future
delineating
impact
stressors
on
clarifying
relevance
functionality
hippocampal–septal–hypothalamic
connectivity,
investigating
neuropeptides
CRH,
oxytocin,
GLP‐1
human
pathogenesis.
Emerging
tools
like
single‐cell
sequencing
advanced
imaging
could
uncover
circuit‐level
changes
areas
relevant
patients.
Ultimately,
by
basic
clinical
research,
science
offers
promising
avenues
developing
personalized,
mechanism‐based
treatments
targeting
maladaptive
behavior
patients
suffering
from
image
Journal of Mass Spectrometry and Advances in the Clinical Lab,
Год журнала:
2025,
Номер
36, С. 19 - 28
Опубликована: Фев. 22, 2025
Oxytocin
is
a
9-amino
acid
peptide
that
serves
as
neuromodulator
in
the
human
central
nervous
system.
This
implicated
regulation
of
diverse
behaviors
and
plays
significant
role
positive
social
interaction.
Currently,
oxytocin
levels
are
measured
using
immunoassays.
However,
these
methods
have
several
limitations
can
lead
to
false
results
erroneous
interpretation.
Given
remarkably
low
endogenous
level
plasma
(low
ng/L
levels),
we
developed
rigorously
validated
novel
highly
sensitive
LC-MS/MS
method
for
quantification
plasma.
was
initially
extracted
solid-phase
extraction
with
an
Oasis
HLB
30
mg
plate
then
subjected
analysis.
PBS-0.1
%
BSA
served
surrogate
matrix
preparation
validation
samples
calibration
curve,
ensuring
no
interference.
The
design
followed
Clinical
Laboratory
Standards
Institute
guidelines.
Precision,
accuracy,
measurement
uncertainty
were
determined
single-nested
analysis
variance
e.noval
software.
A
lower
limit
1
achieved.
concentrations
ranging
from
75
ng/L,
precision
(coefficient
variation)
below
10
%,
accuracy
94
108
15
%.
In
this
work,
Our
methodology
well-suited
clinical
applications.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2070 - 2070
Опубликована: Фев. 27, 2025
Zebrafish
have
the
ability,
to
a
certain
extent,
distinguish
between
different
types
of
stimuli,
including
distinguishing
videos
conspecifics
and
non-conspecifics,
skill
known
as
stimulus
discrimination.
In
this
study,
we
investigated
effects
oxytocin
on
ability
in
albino
non-albino
zebrafish
models,
focusing
correlations
albinism,
sensory
deficiencies,
socio-emotional
behaviors.
Our
hypothesis
is
based
premise
that
influences
behaviors
zebrafish,
with
varying
depending
phenotype
(albino
vs.
non-albino),
social
context,
treatment
duration.
Studies
shown
more
pronounced
meaning
they
may
benefit
from
terms
increased
comfort
interactions
conspecifics,
while
would
experience
reduction
defensive
anxiety.
To
test
this,
two
experiments
were
conducted:
one
assessing
responses
video
predator
stimuli
other
comparing
real
conspecifics.
The
results
showed
significant
differences
groups:
exhibited
stronger
long-term
reductions
anxiety-related
behaviors,
such
reaction
speed
freezing,
suggesting
regulates
aggression.
Meanwhile,
greater
improvements
interactions,
reflecting
nuanced,
phenotype-dependent
oxytocin.
These
not
only
confirm
existing
research
but
also
highlight
therapeutic
potential
treating
deficiencies.
Expert Review of Proteomics,
Год журнала:
2024,
Номер
21(1-3), С. 41 - 53
Опубликована: Фев. 5, 2024
Introduction
Every
year
about
800,000
complete
suicide
events
occur.
The
identification
of
biologic
markers
to
identify
subjects
at
risk
would
be
helpful
in
targeting
specific
support
treatments.
Expert Review of Clinical Immunology,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Окт. 23, 2024
Introduction
Postpartum
mood
disorders
are
heterogenous
and
comprise
postpartum
psychosis
depression.
Evidence
is
accumulating
that
systemic
monocyte/macrophage
activation,
low
grade
inflammation
(premature
senescence
related)
T
cell
defects
increase
the
risk
for
outside
pregnancy
by
affecting
function
of
microglia
cells
in
emotional
brain
(the
cortico-limbic
system)
leading
to
inadequate
regulation
upon
stress.
Frontiers in Psychology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 6, 2024
Developing
a
sense
of
internal
safety
and
security
depends
mainly
on
others:
numerous
neuromodulators
play
significant
role
in
the
homeostatic
process,
regulating
importance
proximity
to
caregiver
experiencing
feelings
that
enable
us
regulate
our
interdependence
with
conspecifics
since
birth.
This
array
neurofunctional
structures
have
been
called
SEPARATION
DISTRESS
system
(now
more
commonly
known
as
PANIC/
GRIEF
system).
emotional
is
involved
production
depressive
symptoms.
The
disruption
this
essential
balance
leads
onset
panic
followed
by
depression.
We
will
focus
neuropeptides
crucial
social
approach
behavior
mammals,
which
enhance
prosocial
facilitate
consolidation
bonds.
propose
most
behaviors
are
regulated
through
specific
acting
salient
intersubjective
stimuli,
reflecting
an
increased
inner
confidence
(safety)
relationships.
review
considers
link
between
may
ultimately
be
at
base
central
neuromodulatory
systems.
shed
light
clinical
implications
for
development
early
mother-infant
bonding
consequences
when
bond
disrupted,
such
post-partum
depression,
connected
to,
addiction,
disorders,
psychological
trauma.
Alzheimer's
disease
(AD)
represents
a
devastating
progressive
neurodegenerative
with
complex
pathophysiology,
affecting
millions
of
people
worldwide.Recent
epigenome-wide
association
studies
suggest
key
role
for
epigenetic
mechanisms
in
its
development
and
course.Despite
the
fact
that
current
evidence
on
dysregulation
aging
AD
is
convincing,
pioneering
field
neuroepigenetics
still
facing
many
challenges
need
to
be
addressed
fundamentally
increase
our
understanding
about
underlying
this
disorder.This
perspective
paper
describes
state
play
research
into
discusses
how
new
methodological
advances
epigenetics
related
data
science
disciplines
could
further
spur
novel
therapeutic
agents
biomarker
assays.
This
review
explores
the
intricate
relationship
between
hormonal
fluctuations
and
emotional
regulation,
emphasizing
critical
role
of
hormones
in
mood,
stress
responses,
psychological
well-being.
By
examining
key
involved
regulation—such
as
those
from
Hypothalamic-Pituitary-Adrenal
(HPA)
axis,
gonadal
(estrogen
testosterone),
thyroid
hormones,
oxytocin,
metabolic
like
insulin,
leptin,
ghrelin—we
uncover
how
these
biochemical
messengers
impact
states
contribute
to
mood
disorders.
The
paper
discusses
methodological
challenges
future
research
directions,
highlighting
necessity
for
interdisciplinary
approaches
deepen
our
understanding
influences
on
regulation.
underscores
importance
considering
mechanisms
developing
targeted
treatments
disorders,
advocating
a
holistic
perspective
that
bridges
endocrinology
psychology.
integrating
current
findings
with
clinical
implications,
objective
is
enhance
biological
foundation
paving
way
innovative
therapeutic
strategies
improved
mental
health
care.
comprehensive
overview
aims
not
only
consolidate
existing
knowledge
but
also
identify
gaps
research,
encouraging
further
exploration
into
underpinnings
states.
Through
this
endeavor,
we
aspire
broader
offering
new
perspectives
treating
disorders
enhancing
overall
