POST-ACUTE SEQUELAE OF COVID-19: CHARACTERIZATION, COMORBIDITIES, AND BIOMARKERS IN A DIVERSE COHORT DOI Creative Commons
Emily L. Struttmann, Anish S. Shah,

Matthew Moreida

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 21, 2024

Abstract Introduction Post-acute sequelae of COVID-19 (PASC) is causing a silent pandemic in the U.S. Gulf South, part flyover where patients are quietly withdrawing from workforce and largely disconnected advocacy resources growing more affluent regions[1]. To date, there no clinical test to diagnose PASC risk factors etiology remain unclear. Methods This prospective study investigates alongside pre-COVID-19 medical history, acute course, panel 25 blood biomarkers collected 100 New Orleans, LA, 52.5% Black cohort, providing unique opportunity describe symptoms associations within comorbidity-rich population. 107 participants recruited ClinSeqSer at University Medical Center (UMC) or Tulane (TMC) Orleans underwent symptom questionnaires 3-month intervals. samples their initial post-COVID follow-up visit were analyzed for cardiac, metabolic, inflammatory, coagulation, chemistry, hematologic markers laboratory. Results SPSS with positivity which was defined as presence three new-since-COVID present 12 weeks after COVID diagnosis. prevalence also demographics past history. Enrolled ranged 21-87 years old (median 53, mean 52.1, STD 13.7). 63% female, Black, 44% White, 3% Asian. 52% hospitalized during course. Severity participants’ prior known most subjects. For 82% subjects, nasal swab saliva SARS CoV-2 qRT-PCR value PCR values did not predict later PASC. Maximum severity scores assigned out 105 whom data collected. On average, reported over 5 75% who completed questionnaire time draw positive. Questionnaire results identified common including fatigue (64%), dyspnea (53%), myalgias (48%), trouble concentrating memory problems (50%). Over one third arthralgias (34%), headaches (40%), sleeping (40%). all reporting these symptoms, average frequency on scale 1 (mild) (severe) follows (frequency; severity): (3.3; 3.3), myalgia (3.4, 3.4), (3.1, 3.2). Comparison means analysis indicates that hemoglobin, hematocrit calcium lower positive but still normal range. Analysis females this 4.8 times likely be classified than males. Serology mild trend toward higher anti-N concentration, plasma proximity extension proteome detected IL-6 TNF, among vs non-PASC. Discussion highly prevalent subjects cohort. A commonly ordered labs unable distinguish non-PASC indicating an ongoing need diagnostic relevant across diverse patient groups.

Язык: Английский

Trends of Common Laboratory Biomarkers after SARS-CoV-2 Infection DOI Creative Commons

Tomer David Meirman,

Bracha Shapira, Ran D. Balicer

и другие.

Journal of Infection, Год журнала: 2024, Номер unknown, С. 106318 - 106318

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

1
CLINICAL AND EPIDEMIOLOGICAL FEATURES OF THE COURSE OF CORONAVIRUS INFECTION DEPENDING ON THE PERIOD OF ILLNESS DOI
Oleksandr Saienko, Mykola Dmytrovych Chemych

Інфекційні хвороби, Год журнала: 2024, Номер 3, С. 28 - 34

Опубликована: Окт. 11, 2024

After the COVID-19 pandemic, persistence of Long COVID symptoms is particular concern, which significantly affects quality life and ability to work. The aim study establish peculiarities clinical epidemiological data in patients infected with SARS-CoV-2 depending on period illness. Patients methods. We examined 108 divided into three groups: those confirmed COVID-19, COVID, practically healthy persons. features course were determined based analysis medical records developed questionnaire. Results. Women predominated among subjects (56 %) an average age 41.44 years. main that characterized picture generalized weakness/fatigue (94 %), headache (74 fever/body aches cough 71 % (p<0.05). In group, compared (40 (29 (3 (9 less common, sleep disorders / insomnia (17 muscle pain (11 shortness breath runny nose sneezing (6 loss (worsening) appetite sore throat difficulty concentrating abdominal Conclusions. Reduced access healthcare services leads delayed hospitalization, prolonged treatment, complications. level vaccination does not affect risk COVID. Clinical signs COVID: weakness/fatigue, anxiety, mood disturbance, are detected one third cause a decrease overall life. most persistent general headache, breath, disorders/insomnia persist 34-42 from moment confirmed.

Язык: Английский

Процитировано

1
Post-COVID syndrome in patients with type 2 diabetes: definition, epidemiology, pathophysiology, biomarkers and genetic associations DOI Creative Commons
S. A. Sukhanov, Yu. А. Sorokina, О. В. Занозина

и другие.

Meditsinskiy sovet = Medical Council, Год журнала: 2024, Номер 6, С. 89 - 97

Опубликована: Апрель 24, 2024

The article presents the modern ideas about post-COVID syndrome, indicates various types and classifications of provides epidemiological data, including patients with type 2 diabetes, also definition syndrome is given. group defined as very heterogeneous. Post-COVID more common in elderly, comorbid pathology, severe disease. pathophysiology this diabetes mellitus analyzed, risk factors are indicated. main biomarkers disorders were determined: monocytes their coefficients, acute phase proteins, some biochemical indicators, analysis genetic associations severity (interferon gamma gene, methylenetetrahydrofolate reductase ACE2 inhibitor). Genotyping a sample 26 single nucleotide polymorphisms genes implicated viral entry, immune response, inflammation significantly associated not only long-term COVID-19 symptoms, but cumulative incidence syndrome. Elevated levels interleukin 6, C-reactive protein tumor necrosis factor alpha may serve potential diagnostic COVID blood vascular transformation have great for diagnosis, angiogenesis modulators therapeutic efficacy It has been shown that vast majority patients, particular those suffering from develop post-COVID-19 taking into account pre-existing diseases, so harmless. By identifying associations, it possible to identify molecular mechanism mellitus. novelty disease association studies context new insights management rapidly evolving syndromes significant global implications.

Язык: Английский

Процитировано

0
Diaphragmatic strengthening exercises for patients with post COVID-19 condition after mild-to-moderate acute COVID-19 infection: a randomized controlled study DOI Creative Commons
Tamer I. Abo Elyazed,

Ahmed Abd El‐Moneim Abd El‐Hakim,

Ola I. Saleh

и другие.

Journal of Rehabilitation Medicine, Год журнала: 2024, Номер 56, С. jrm25491 - jrm25491

Опубликована: Июнь 11, 2024

Objective: To assess the clinical effects of incentive spirometry (IS) and diaphragmatic breathing (DB) in patients with post COVID-19 condition dysfunction as compared standard care alone. Methods: The present longitudinal randomized study included 60 dysfunction. Patients were equally to receive plus IS (G1), DB (G2) or alone (G3) for 8 weeks. primary outcome is improvement evaluated by modified Medical Research Council (mMRC) dyspnoea scale. Results: Comparison between studied groups revealed significant G1 G2 all parameters at end follow-up. However, no was found G3. At follow-up, 15 (75.0%) G1, 11 (55.0%) G2, 3 (15.0%) G3 showed on mMRC Multivariate logistic regression analysis identified mild acute infection (p = 0.009), use < 0.001), 0.023) predictors Conclusions: training addition associated better

Язык: Английский

Процитировано

0
POST-ACUTE SEQUELAE OF COVID-19: CHARACTERIZATION, COMORBIDITIES, AND BIOMARKERS IN A DIVERSE COHORT DOI Creative Commons
Emily L. Struttmann, Anish S. Shah,

Matthew Moreida

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 21, 2024

Abstract Introduction Post-acute sequelae of COVID-19 (PASC) is causing a silent pandemic in the U.S. Gulf South, part flyover where patients are quietly withdrawing from workforce and largely disconnected advocacy resources growing more affluent regions[1]. To date, there no clinical test to diagnose PASC risk factors etiology remain unclear. Methods This prospective study investigates alongside pre-COVID-19 medical history, acute course, panel 25 blood biomarkers collected 100 New Orleans, LA, 52.5% Black cohort, providing unique opportunity describe symptoms associations within comorbidity-rich population. 107 participants recruited ClinSeqSer at University Medical Center (UMC) or Tulane (TMC) Orleans underwent symptom questionnaires 3-month intervals. samples their initial post-COVID follow-up visit were analyzed for cardiac, metabolic, inflammatory, coagulation, chemistry, hematologic markers laboratory. Results SPSS with positivity which was defined as presence three new-since-COVID present 12 weeks after COVID diagnosis. prevalence also demographics past history. Enrolled ranged 21-87 years old (median 53, mean 52.1, STD 13.7). 63% female, Black, 44% White, 3% Asian. 52% hospitalized during course. Severity participants’ prior known most subjects. For 82% subjects, nasal swab saliva SARS CoV-2 qRT-PCR value PCR values did not predict later PASC. Maximum severity scores assigned out 105 whom data collected. On average, reported over 5 75% who completed questionnaire time draw positive. Questionnaire results identified common including fatigue (64%), dyspnea (53%), myalgias (48%), trouble concentrating memory problems (50%). Over one third arthralgias (34%), headaches (40%), sleeping (40%). all reporting these symptoms, average frequency on scale 1 (mild) (severe) follows (frequency; severity): (3.3; 3.3), myalgia (3.4, 3.4), (3.1, 3.2). Comparison means analysis indicates that hemoglobin, hematocrit calcium lower positive but still normal range. Analysis females this 4.8 times likely be classified than males. Serology mild trend toward higher anti-N concentration, plasma proximity extension proteome detected IL-6 TNF, among vs non-PASC. Discussion highly prevalent subjects cohort. A commonly ordered labs unable distinguish non-PASC indicating an ongoing need diagnostic relevant across diverse patient groups.

Язык: Английский

Процитировано

0