Next Materials, Год журнала: 2025, Номер 8, С. 100647 - 100647
Опубликована: Апрель 16, 2025
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(22), С. 16357 - 16357
Опубликована: Ноя. 15, 2023
According to the World Health Organization (WHO), around 11 million people suffer from burns every year, and 180,000 die them. A burn is a condition in which heat, chemical substances, an electrical current or other factors cause tissue damage. Burns mainly affect skin, but can also deeper tissues such as bones muscles. When burned, skin loses its main functions, protection external environment, pathogens, evaporation heat loss. Depending on stage of burn, patient’s we need choose most appropriate treatment. Personalization multidisciplinary collaboration are key successful management patients. In this comprehensive review, have collected discussed available treatment options, focusing recent advances topical treatments, wound cleansing, dressings, grafting, nutrition, pain scar management.
Язык: Английский
Процитировано
46
ChemistrySelect, Год журнала: 2024, Номер 9(23)
Опубликована: Июнь 18, 2024
Abstract Recently, mesoporous silica nanoparticles (MSNs) have emerged as promising candidates in the field of hemorrhage control owing to their extended pore size, high surface area, and excellent biocompatibility. These characteristics directly influence toxicity cells, loading therapeutic agents, release active ions during hemostasis process. Therefore, understanding fundamentals tuning these is important design types carriers. While several literature reviews explored role MSNs control, comprehensive studies focusing on general specific applications remain scarce. This review concentrates principles synthesizing silica, MSNs, techniques for drugs methods onto site injury, kinetics models, biocompatibility, toxicity, unique properties MSNs. Furthermore, article examines mechanism action nanomaterial hemostatic agents.
Язык: Английский
Процитировано
28
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 275, С. 133526 - 133526
Опубликована: Июль 2, 2024
Язык: Английский
Процитировано
27
Marine Drugs, Год журнала: 2023, Номер 21(12), С. 613 - 613
Опубликована: Ноя. 26, 2023
A Chitosan is a copolymer of N-acetyl-D-glucose amine and D-glucose that can be easily produced. It polymer widely utilized to create nanoparticles (NPs) with specific properties for applications in wide range human activities. substance excellent prospects due its antibacterial, anti-inflammatory, antifungal, haemostatic, analgesic, mucoadhesive, osseointegrative qualities, as well superior film-forming capacity. serve variety functions the pharmaceutical medical fields, including dentistry. According recent research, chitosan derivatives embedded materials dental adhesives, barrier membranes, bone replacement, tissue regeneration, antibacterial agents improve management oral diseases. This narrative review aims discuss development chitosan-containing implant engineering applications, challenges future potential. For this purpose, PubMed database (Medline) was utilised search publications published less than 10 years ago. The keywords used were "chitosan coating" "dentistry". After carefully selecting according these keywords, 23 articles studied. concluded biocompatible bioactive material many benefits surgery, restorative dentistry, endodontics, prosthetics, orthodontics, disinfection. Furthermore, despite fact it highly significant promising coating, there still demand various types coatings. semi-synthetic polysaccharide has because antimicrobial properties. article role implantology.
Язык: Английский
Процитировано
23
IntechOpen eBooks, Год журнала: 2024, Номер unknown
Опубликована: Май 23, 2024
Conventional therapeutic models based on the premise of a universal solution are facing decrease in efficiency, emphasized by large number patients who show resistance or do not respond positively to classic treatments. This perspective highlights urgency for more precise approaches personalized treatments that adaptable specific complexities and unique challenges faced each patient. Hydrogels biocompatible biodegradable systems well-controlled targeted administration agents, being formed 3D reticulated networks water-soluble polymeric biomaterials, natural, synthetic, hybrid origin, with intrinsic extrinsic properties. Due easily adjustable porous structure, hydrogels allow encapsulation macromolecular drugs, proteins, small molecules, cells, hormones, growth factors gel matrix their subsequent controlled release. The biomaterials used, crosslinking methods, design, functionalization strategies obtaining improved properties presented. different possibilities application described transdermally, as dressing materials, oral, ocular, spray-able, injectable, up intracellular level. chapter extensively investigates advances advantages enable effective, noninvasive, provide greater patient comfort wide range applications.
Язык: Английский
Процитировано
10
Polymer Bulletin, Год журнала: 2024, Номер unknown
Опубликована: Сен. 30, 2024
Язык: Английский
Процитировано
10
Polymers, Год журнала: 2024, Номер 16(13), С. 1770 - 1770
Опубликована: Июнь 22, 2024
Wounds caused by trauma and/or surgery represent a significant challenge in contemporary medical practice, requiring innovative approaches to promote optimal healing and reduce the risk of bleeding complications resulting from it. In this context, chitosan, natural polysaccharide derived chitin, represents an ideal material for study application devices, form dressings, wound management pre- post-operative wounds due its ability induce hemostasis high biocompatibility with biological tissues. The aim work was discuss structural characteristics, properties chitosan-based hemostatic dressings processes or post-surgical approaches.
Язык: Английский
Процитировано
9
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 136421 - 136421
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
9
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141570 - 141570
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5249 - 5249
Опубликована: Май 11, 2024
In clinical practice, tissue adhesives have emerged as an alternative tool for wound treatments due to their advantages in ease of use, rapid application, less pain, and minimal damage. Since most are designed internal use or treatments, the biodegradation is important. To endow with biodegradability, past few decades, various biodegradable polymers, either natural polymers (such chitosan, hyaluronic acid, gelatin, chondroitin sulfate, starch, sodium alginate, glucans, pectin, functional proteins, peptides) synthetic poly(lactic acid), polyurethanes, polycaprolactone, poly(lactic-co-glycolic acid)), been utilized develop novel adhesives. Incorporated degraded vivo time under specific conditions, leading destruction structure further degradation this review, we first summarize strategies utilizing Furthermore, provide a symmetric overview used adhesives, focus on degradability applications these Additionally, challenges perspectives polymer-based discussed. We expect that review can new inspirations design biomedical applications.
Язык: Английский
Процитировано
7