Research Progress on Pathogenesis and Treatment of Sjögren’s Syndrome with Traditional Chinese and Western Medicine
Advances in Clinical Medicine,
Год журнала:
2024,
Номер
14(08), С. 1537 - 1542
Опубликована: Янв. 1, 2024
Язык: Английский
Uncovering the Therapeutic Target and Molecular Mechanism of Upadacitinib on Sjogren’s Syndrome
Biomedical Engineering and Computational Biology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 1, 2024
Upadacitinib,
a
selective
Janus
associated
kinase
1
(JAK-1)
inhibitor,
can
be
prescribed
particularly
for
the
clinical
treatment
with
Crohn's
disease
or
rheumatoid
arthritis.
It
is
clinically
observed
that
upadacitinib
has
been
found
potential
therapeutic
effectiveness
on
Sjogren's
syndrome
(SS).
However,
anti-SS
targets
and
mechanisms
involved
in
remain
uninvestigated.
Язык: Английский
Association between cytokine cycling levels and Sjogren's syndrome: genetic correlation and bidirectional Mendelian randomization study
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 20, 2024
Abstract
Background
Sjogren's
syndrome
(SS)
is
a
complex
autoimmune
disease
influenced
by
genetics,
yet
its
genetic
underpinnings
remain
elusive.
This
study
investigates
the
correlation
and
potential
causative
link
between
cytokine
cycling
levels
SS.
Methods
Genome-wide
association
studies
(GWAS)
were
conducted
with
8,293
14,824
European
participants
to
identify
cytokines.
The
GWAS
dataset
for
SS,
comprising
368,028
individuals
of
ancestry
(2,495
cases
365,533
controls),
was
sourced
from
Finnish
biological
sample
library.
Single
nucleotide
polymorphisms
(SNPs)
associated
SS
identified
using
Linkage
disequilibrium
score
(LDSC)
regression
Mendelian
randomization
(MR)
analysis.
inverse
variance
weighted
(IVW)
method
primary
analytical
approach.
Additional
methods
including
MR
Egger,
Weighted
median,
mode
employed
robustness
assessment.
Heterogeneity
testing,
horizontal
pleiotropy
Steiger
testing
sensitivity
Reverse
analysis
performed
assess
reverse
causal
relationship
Results
LDSC
46
cytokines
bidirectional
IVW
revealed
significant
associations
genetically
predicted
IL10RB
(P
=
0.019,
OR
1.138,
95%
CI:
1.021–1.267)
CXCL11
0.015,
1.269,
1.048–1.537)
increased
risk.
absence
heterogeneity
in
underscores
these
findings.
Conclusion
suggests
particularly
through
cycles.
Further
research
warranted
elucidate
mechanisms
which
influence
Язык: Английский
Intracranial Hypertension as a rare presentation of Sjögren's Syndrome: a case report
Revista Neurociências,
Год журнала:
2024,
Номер
32, С. 1 - 10
Опубликована: Март 21, 2024
Introduction.
A
rare
extraglandular
manifestation
of
Sjögren's
syndrome
is
presented,
mimicking
idiopathic
intracranial
hypertension.
Case
Report.
young
eutrophic
female,
complained
persistent
headache,
followed
by
diplopia
and
bilateral
sixth
nerve
paresis.
Neuroimaging
investigation
showed
classic
signs
As
the
patient
had
a
normal
weight,
prompted
evaluation
secondary
causes,
which
revealed
positive
anti-SSA/Ro
anti-La/SSB
antibodies.
salivary
gland
biopsy
later
confirmed
diagnosis
syndrome.
Xerostomia
dysphagia
developed
weeks
later.
Conclusion.
This
case
report
important
to
raise
awareness
about
an
atypical
neurological
Язык: Английский
Novel and potential future therapeutic options in Sjögren's syndrome
Heliyon,
Год журнала:
2024,
Номер
10(19), С. e38803 - e38803
Опубликована: Окт. 1, 2024
Язык: Английский
Basement Membrane Mimetic Hydrogel Cooperates with Rho‐Associated Protein Kinase Inhibitor to Promote the Development of Acini‐Like Salivary Gland Spheroids
Advanced NanoBiomed Research,
Год журнала:
2023,
Номер
3(11)
Опубликована: Окт. 8, 2023
Successful
engineering
of
functional
salivary
glands
necessitates
the
creation
cell‐instructive
environments
for
ex
vivo
expansion
and
lineage
specification
primary
human
gland
stem
cells
(hS/PCs).
Herein,
basement
membrane
mimetic
hydrogels
are
prepared
using
hyaluronic
acid,
cell
adhesive
peptides,
hyperbranched
polyglycerol
(HPG),
with
or
without
sulfate
groups,
to
produce
“hyperGel+”
“hyperGel”,
respectively.
Differential
scanning
fluorescence
experiments
confirm
ability
sulfated
HPG
precursor
stabilize
fibroblast
growth
factor
10.
The
nanoporous,
cytocompatible,
cell‐permissive,
enabling
development
multicellular
hS/PC
spheroids
in
14
days.
incorporation
species
hydrogel
enhances
proliferation.
Culture
hS/PCs
hyperGel+
presence
a
Rho
kinase
inhibitor
Y‐27632
(Y‐27)
leads
central
lumen,
increases
expression
acinar
marker
aquaporin‐3
at
transcript
level
(
AQP3
),
decreases
ductal
keratin
7
both
KRT7
)
protein
levels
(K7).
Reduced
transforming
beta
(TGF‐β)
targets
SMAD2/3
is
also
observed
Y27‐treated
cultures,
suggesting
attenuation
TGF‐β
signaling.
Thus,
cooperates
Rho‐associated
promote
lumened
enhanced
markers.
Язык: Английский
