ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(20), С. 23397 - 23415
Опубликована: Окт. 12, 2024
Hydrogen
sulfide
(H2S)
is
recognized
as
the
third
gaseous
signaling
molecule
present,
playing
a
crucial
role
in
cellular
processes.
When
designing
nanomaterials,
H2S
not
only
serves
cancer
biomarker
but
also
directly
influences
tumor
cell
proliferation
and
metastasis
by
modulating
its
concentration.
However,
gas
donor
inability
to
actively
accumulate
within
tumors
release
controlled
manner
results
restricted
treatment
efficacy
potential
toxic
side
effects.
Near-infrared
(NIR)
responsive
photothermal
probes
are
characterized
their
rapid
response
time,
high
selectivity,
sensitivity,
noninvasive
attributes.
They
offer
opportunity
for
precise,
real-time,
modulation
of
concentrations
at
both
murine
levels.
The
integration
therapy
with
other
modalities
through
multifunctional
nanocarrier
platforms
shows
promise
enhancing
outcomes
while
minimizing
adverse
development
capable
controllably
properties
considered
essential
yet
challenging
academic
research.
This
Review
critically
assesses
two
primary
approaches
NIR
strategies
involving
H2S:
targeted
utilizing
combining
alternative
modalities.
Additionally,
this
addresses
current
limitations
these
technologies
outlines
future
directions
advancement.
Overall,
aims
provide
insights
guidance
seamless
therapy,
aligning
rigorous
standards
journals.
Antioxidants,
Год журнала:
2023,
Номер
12(9), С. 1737 - 1737
Опубликована: Сен. 7, 2023
Hydrogen
sulfide
(H2S),
traditionally
recognized
as
a
toxic
gas,
has
emerged
critical
regulator
in
many
biological
processes,
including
oxidative
stress
and
cellular
homeostasis.
This
review
presents
an
exhaustive
overview
of
the
current
understanding
H2S
its
multifaceted
role
mammalian
functioning
management.
We
delve
into
sources
function
H2S,
mechanisms
underlying
homeostasis,
intricate
relationships
between
these
processes.
explore
evidence
from
recent
experimental
clinical
studies,
unraveling
biochemical
molecular
dictating
H2S’s
roles
modulating
responses
maintaining
The
implications
therapeutic
potential
conditions
characterized
by
dysregulation
disrupted
homeostasis
are
discussed,
highlighting
emerging
significance
health
disease.
Finally,
this
underscores
challenges,
controversies,
future
directions
field,
emphasizing
need
for
further
research
to
harness
agent
diseases
associated
with
homeostatic
imbalance.
Through
review,
we
aim
emphasize
pivotal
function,
encouraging
exploration
burgeoning
area
research.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(11), С. 1480 - 1480
Опубликована: Ноя. 4, 2024
The
intricate
relationship
between
hydrogen
sulfide
(H2S),
gut
microbiota,
and
sirtuins
(SIRTs)
can
be
seen
as
a
paradigm
axis
in
maintaining
cellular
homeostasis,
modulating
oxidative
stress,
promoting
mitochondrial
health,
which
together
play
pivotal
role
aging
neurodegenerative
diseases.
H2S,
gasotransmitter
synthesized
endogenously
by
specific
acts
potent
modulator
of
function
protecting
against
damage.
Through
sulfate-reducing
bacteria,
microbiota
influences
systemic
H2S
levels,
creating
link
health
metabolic
processes.
Dysbiosis,
or
an
imbalance
microbial
populations,
alter
production,
impair
function,
increase
heighten
inflammation,
all
contributing
factors
diseases
such
Alzheimer’s
Parkinson’s.
Sirtuins,
particularly
SIRT1
SIRT3,
are
NAD+-dependent
deacetylases
that
regulate
biogenesis,
antioxidant
defense,
inflammation.
enhances
sirtuin
activity
through
post-translational
modifications,
sulfhydration,
activate
pathways
essential
for
mitigating
damage,
reducing
longevity.
SIRT1,
example,
deacetylates
NF-κB,
pro-inflammatory
cytokine
expression,
while
SIRT3
modulates
key
enzymes
to
improve
energy
metabolism
detoxify
reactive
oxygen
species
(ROS).
This
synergy
is
profoundly
influenced
the
levels
and,
turn,
impacts
activation.
microbiota–H2S–sirtuin
also
regulating
neuroinflammation,
plays
central
pathogenesis
Pharmacological
interventions,
including
donors
sirtuin-activating
compounds
(STACs),
promise
these
synergistically,
providing
novel
therapeutic
approach
conditions.
suggests
diversity
optimal
have
far-reaching
effects
on
brain
health.
Biomedicines,
Год журнала:
2024,
Номер
12(9), С. 1951 - 1951
Опубликована: Авг. 26, 2024
Atherosclerosis
is
a
chronic
inflammatory
condition
marked
by
endothelial
dysfunction,
lipid
accumulation,
cell
infiltration,
and
extracellular
matrix
(ECM)
remodeling
within
arterial
walls,
leading
to
plaque
formation
potential
cardiovascular
events.
Key
players
in
ECM
inflammation
are
metalloproteinases
(MMPs)
CD147/EMMPRIN,
surface
glycoprotein
expressed
on
cells,
vascular
smooth
muscle
cells
(VSMCs),
immune
that
regulates
MMP
activity.
Hydrogen
sulfide
(H₂S),
gaseous
signaling
molecule,
has
emerged
as
significant
modulator
of
these
processes
including
oxidative
stress
mitigation,
reduction,
remodeling.
This
systematic
review
investigates
the
mechanistic
pathways
through
which
H₂S
influences
MMPs
CD147/EMMPRIN
assesses
its
impact
atherosclerosis
progression.
A
comprehensive
literature
search
was
conducted
across
PubMed,
Scopus,
Web
Science
databases,
focusing
studies
examining
modulation
contexts.
Findings
indicate
modulates
expression
activity
transcriptional
regulation
post-translational
modifications,
S-sulfhydration.
By
mitigating
stress,
reduces
activation,
contributing
stability
also
downregulates
via
pathways,
diminishing
responses
cellular
proliferation
plaques.
The
dual
regulatory
role
inhibiting
downregulating
CD147
suggests
therapeutic
agent
stabilizing
atherosclerotic
plaques
inflammation.
Further
research
warranted
elucidate
precise
molecular
mechanisms
explore
H₂S-based
therapies
for
clinical
application
atherosclerosis.
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1062 - 1062
Опубликована: Авг. 30, 2024
Neurodegenerative
diseases
encompass
a
spectrum
of
disorders
marked
by
the
progressive
degeneration
structure
and
function
nervous
system.
These
conditions,
including
Parkinson's
disease
(PD),
Alzheimer's
(AD),
Huntington's
(HD),
Amyotrophic
lateral
sclerosis
(ALS),
Multiple
(MS),
often
lead
to
severe
cognitive
motor
deficits.
A
critical
component
neurodegenerative
pathologies
is
imbalance
between
pro-oxidant
antioxidant
mechanisms,
culminating
in
oxidative
stress.
The
brain's
high
oxygen
consumption
lipid-rich
environment
make
it
particularly
vulnerable
damage.
Pro-oxidants
such
as
reactive
nitrogen
species
(RNS)
(ROS)
are
continuously
generated
during
normal
metabolism,
counteracted
enzymatic
non-enzymatic
defenses.
In
diseases,
this
balance
disrupted,
leading
neuronal
This
systematic
review
explores
roles
stress,
gut
microbiota,
epigenetic
modifications
aiming
elucidate
interplay
these
factors
identify
potential
therapeutic
strategies.
We
conducted
comprehensive
search
articles
published
2024
across
major
databases,
focusing
on
studies
examining
relationships
redox
homeostasis,
changes
neurodegeneration.
total
161
were
included,
comprising
clinical
trials,
observational
studies,
experimental
research.
Our
findings
reveal
that
stress
plays
central
role
pathogenesis
with
microbiota
composition
significantly
influencing
balance.
Specific
bacterial
taxa
markers
identified
modulators
suggesting
novel
avenues
for
intervention.
Moreover,
recent
evidence
from
human
animal
supports
emerging
concept
targeting
homeostasis
through
therapies.
Future
research
should
focus
validating
targets
settings
exploring
personalized
medicine
strategies
based
individual
profiles.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 344 - 344
Опубликована: Фев. 27, 2025
Age-related
oxidative
stress
is
a
critical
factor
in
vascular
dysfunction,
contributing
to
hypertension
and
atherosclerosis.
Smooth
muscle
cells
endothelial
are
particularly
susceptible
damage,
which
exacerbates
aging
through
cellular
senescence,
chronic
inflammation,
arterial
stiffness.
Gasotransmitters—hydrogen
sulfide
(H2S),
nitric
oxide
(NO),
carbon
monoxide
(CO)—are
emerging
as
promising
therapeutic
agents
for
counteracting
these
processes.
This
review
synthesizes
findings
from
recent
studies
focusing
on
the
mechanisms
by
H2S,
NO,
CO
influence
smooth
cell
function.
Therapeutic
strategies
involving
exogenous
gasotransmitter
delivery
systems
combination
therapies
were
analyzed.
H2S
enhances
mitochondrial
bioenergetics,
scavenges
ROS,
activates
antioxidant
pathways.
NO
improves
function,
promotes
vasodilation,
inhibits
platelet
aggregation.
exhibits
cytoprotective
anti-inflammatory
effects
modulating
heme
oxygenase
activity
ROS
production.
In
preclinical
studies,
gasotransmitter-releasing
molecules
(e.g.,
NaHS,
SNAP,
CORMs)
targeted
show
significant
promise.
Synergistic
with
lifestyle
modifications
further
enhance
their
potential.
conclusion,
gasotransmitters
hold
promise
combat
age-related
cells.
Their
multifaceted
innovative
approaches
make
them
potential
candidates
treating
dysfunction
promoting
healthy
aging.
Further
research
needed
translate
into
clinical
applications.
