International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139017 - 139017
Опубликована: Дек. 1, 2024
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 172, С. 116207 - 116207
Опубликована: Янв. 31, 2024
Lung cancer ranks among the most prevalent forms of and remains a significant factor in cancer-related mortality across world. It poses challenges to healthcare systems society as whole due its high incidence, rates, late-stage diagnosis. Resveratrol (RV), natural compound found various plants, has shown potential nanomedicine for lung treatment. RV varied effects on cells, including promoting apoptosis by increasing pro-apoptotic proteins (Bax Bak) decreasing anti-apoptotic (Bcl-2). also hinders cell proliferation influencing important signaling pathways (MAPK, mTOR, PI3K/Akt, Wnt/β-catenin) that govern progression. In addition, acts potent antioxidant, diminishing oxidative stress safeguarding cells against DNA damage. However, using alone treatment drawbacks, such low bioavailability, lack targeting ability, susceptibility degradation. contrast, nanoparticle-based delivery address these limitations hold promise improving outcomes cancer; nanoparticle formulations offer advantages improved drug delivery, increased stability, controlled release, targeted cells. This article will provide an overview cancer, explore therapeutic agent, discuss benefits highlight nanoparticles treatment, cancer. By optimizing clinical application, future studies aim enhance overall improve prognosis patients.
Язык: Английский
Процитировано
23
Scientia Pharmaceutica, Год журнала: 2024, Номер 92(2), С. 28 - 28
Опубликована: Май 22, 2024
The incidence of cancer is growing every year and covers all age groups, including the working population, which makes socially significant. Existing methods treatment, despite effectiveness individual compounds in relation to cells, are not perfect due a number side effects associated with high doses that physicians forced administer when using treatment protocols. A particularly difficult issue creation effective functional containers would have properties targeting certain types cells. solution this problem currently relevant, reflected growth publications on subject recent years. most promising use nanotechnology development bioengineered therapeutics for chemotherapeutic agents. In review, we tried assess trends exist area research, as well show wide some commercially available formulations based nano-sized vehicles.
Язык: Английский
Процитировано
9
Heliyon, Год журнала: 2024, Номер 10(3), С. e25477 - e25477
Опубликована: Фев. 1, 2024
The health of the reproductive system is intricately linked to female fertility and quality life. There has been a growing prevalence disorders among women, particularly in younger age groups, resulting significant adverse effects on their health. Consequently, there an urgent need for effective treatment modalities. Nanotechnology, as advanced discipline, provides innovative avenues managing treating diseases by enabling precise manipulation regulation biological molecules cells. By utilizing nanodelivery systems, drugs can be administered with pinpoint accuracy, leading reduced side improved therapeutic efficacy. Moreover, nanomaterial imaging techniques enhance diagnostic precision sensitivity, aiding assessment disease severity progression. Furthermore, implementation nanobiosensors facilitates early detection prevention ailments. This comprehensive review aims summarize recent applications nanotechnology diseases. latest advancements drug delivery, diagnosis, approaches will discussed, emphasis potential improve outcomes overall
Язык: Английский
Процитировано
8
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 697, С. 134409 - 134409
Опубликована: Июнь 2, 2024
Язык: Английский
Процитировано
6
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 1723 - 1748
Опубликована: Фев. 1, 2024
Given the unique physiological and pathological characteristics of lung, direct, inhalable route is more conducive to pulmonary drug delivery disease control than traditional systemic delivery, significantly circumventing loss, off-target effects, organ toxicity, etc., widely regarded as preferred regimen for delivery.However, very few lung diseases are currently treated with inhaled formulations, such asthma, chronic obstructive hypertension.And there a lack appropriate formulations other critical diseases, cancer fibrosis, due fact that physicochemical properties drugs their pharmacokinetic profiles do not match physiology conventional inhalation devices unable deliver them specific parts lung.Phytochemicals natural origin, wide availability clear safety profile, hold great promise preparation improve current dilemma in treatment diseases.In particular, based on nano-and microparticulate carriers deep tissues, which overcome shortcomings therapies while targeting activity directly part may be best approach change treatment.In this review, we discuss recent advances micron-carrier-based products represent an opportunity practical clinical translation products.
Язык: Английский
Процитировано
5
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2024, Номер 29(11), С. 2415 - 2415
Опубликована: Май 21, 2024
Myocardial infarction (MI) is one of the most prevalent types cardiovascular disease. During MI, myocardial cells become ischemic and necrotic due to inadequate blood perfusion, leading irreversible damage heart. Despite development therapeutic strategies for prevention treatment their effects are still unsatisfactory. Nanoparticles represent a new strategy pre-treatment novel multifunctional nanoparticles with preventive capabilities hold promise this This review summarizes common properties nanoparticles, focuses on research progress MI.
Язык: Английский
Процитировано
4
Molecules, Год журнала: 2024, Номер 29(12), С. 2853 - 2853
Опубликована: Июнь 15, 2024
Purpose of the study: creation a dextran coating on cerium oxide crystals using different ratios and to synthesize nanocomposites, selection best nanocomposite develop nanodrug that accelerates quality wound healing with new type antimicrobial effect. Materials methods: Nanocomposites were synthesized nitrate polysaccharide (6000 Da) at four initial Ce(NO3)3x6H2O (by weight)—1:0.5 (Ce0.5D); 1:1 (Ce1D); 1:2 (Ce2D); 1:3 (Ce3D). A series physicochemical experiments performed characterize created nanocomposites: UV-spectroscopy; X-ray phase analysis; transmission electron microscopy; dynamic light scattering IR-spectroscopy. The biomedical effects nanocomposites studied human fibroblast cell culture an evaluation their effect metabolic proliferative activity cells MTT test direct counting. Antimicrobial was by mass spectrometry gas chromatography–mass against E. coli after 24 h 48 co-incubation. Results: According studies, nanocrystals less than 5 nm in size diffraction peaks characteristic dioxide identified all nanocomposites. With increasing concentration, particle decreased, smallest nanoparticles (<2 nm) Ce2D Ce3D composites. results showed high level safety nanoceria, while absence cytotoxicity (100% survival rate) established for C3D sols. At nanoceria concentration 10−2 M, fibroblasts statistically significantly enhanced only when co-cultured Ce2D, but decreased Ce3D. 72 co-cultivation nano composites increased highest registered Ce3D; from group, differences As result microbiological study, (bacteriostatic effect) found Ce0.5D which inhibited multiplication average 22–27%, h, suppressed 58–77%, most pronounced Ce0.5D, Ce1D, Ce2D. Conclusions: necessary physical characteristics nanoceria–dextran provide biological determined. 10−3 stimulates proliferation metabolism up 2.5 times allows reduction rate microorganism three times, selected subsequent creation.
Язык: Английский
Процитировано
4
Molecules, Год журнала: 2024, Номер 29(16), С. 3784 - 3784
Опубликована: Авг. 9, 2024
Cancer is a complex disease that affects millions of people and remains major public health problem worldwide. Conventional cancer treatments, including surgery, chemotherapy, immunotherapy, radiotherapy, have limited achievements multiple drawbacks, among which are healthy tissue damage multidrug-resistant phenotype onset. Increasing evidence shows many plants’ natural products, as well their bioactive compounds, promising anticancer activity exhibit minimal toxicity compared to conventional drugs. However, widespread use in therapy severely restricted by limitations terms water solubility, absorption, lack stability, bioavailability, selective targeting. The nanoformulations for product transportation delivery could be helpful overcoming these limitations, thus enhancing therapeutic efficacy providing the basis improved treatment strategies. present review aimed at an update on some phytocompounds (curcumin, resveratrol, quercetin, cannabinoids, others) main showing antitumor activities, both vitro vivo, against such different human types breast colorectal cancer, lymphomas, malignant melanoma, glioblastoma multiforme, osteosarcoma. intracellular pathways underlying phytocompound advantages nanoformulation employment also examined. Finally, this critically analyzes research gaps causing success phytocompounds’ nanoformulations’ clinical translation.
Язык: Английский
Процитировано
4
Materials, Год журнала: 2025, Номер 18(2), С. 248 - 248
Опубликована: Янв. 8, 2025
Due to their intriguing emission profile, Terbium-161 (161Tb) radiopharmaceuticals seem bring significant advancement in theranostic applications cancer treatment. The combination of 161Tb with nanoscale brachytherapy as an approach for treatment is particularly advantageous and promising. Herein, we propose the application a hybrid nanosystem comprising gold decorated (Au@TADOTAGA) iron oxide nanoflowers form injectable nanobrachytherapy local breast cancer. More specifically, Au@TADOTAGA NFAu@TADOTAGA NPs were efficiently radiolabeled 161Tb, vitro stability was assessed up 21 d post-radiolabeling. Furthermore, cytotoxic profile against 4T1 cells evaluated, ex vivo biodistribution characteristics revealed after intratumoral injection same animal model. enhanced retention at tumor site urged us evaluate therapeutic effect [161Tb]Tb-NFAu@TADOTAGA administration 4T1-tumor-bearing mice, over period 24 days. Three different protocols performed order identify which would offer optimum results proposed promising agent.
Язык: Английский
Процитировано
0