Comparison of post-acute sequelae following hospitalization for COVID-19 and influenza DOI Creative Commons

Ting-Hui Liu,

Po‐Yu Huang, Jheng‐Yan Wu

и другие.

BMC Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Дек. 5, 2023

Abstract Background Few studies have directly compared the risk and magnitude of post-acute sequelae following COVID-19 influenza, most these were conducted before emergence Omicron. This study investigated prevalence post-COVID conditions long-term emergency department (ED) visits, hospitalizations, deaths in patients with their that influenza. Methods A retrospective based on TriNetX databases, a global health research network. We identified influenza who required hospitalization between January 1, 2022, 2023. developing any two groups also analyzed each post-COVID-19 condition all-cause ED both populations during follow-up 90–180 days. Results Before matching, 7,187 older (63.9 ± 16.7 vs. 55.4 21.2) predominantly male (54.0% 45.4%), overweight/obese (16.1% 11.2%) than 11,266 individuals After propensity score 6,614 group, resulting well-balanced baseline characteristics. During follow-up, group had higher incidence when (17.9% 13.0%), hazard ratio (HR) 1.398 (95% CI, 1.251–1.562). Compared to significantly abnormal breathing (HR, 1.506; 95% 1.246–1.822), abdominal symptoms 1.313; HR, 1.034–1.664), fatigue 1.486; 1.158–1.907), cognitive 1.815; 1.235–2.668). Moreover, composite outcomes (27.5% 21.7; 1.303; 1.194–1.422). Conclusions indicates hospitalized are at complications survivors.

Язык: Английский

Positionspapier zum Post-COVID-Syndrom DOI

Elisabeth Schieffer,

Denise Hilfiker‐Kleiner, Axel Schlitt

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Процитировано

0
Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics DOI Creative Commons

Grant Talkington,

Paresh Kolluru,

Timothy E. Gressett

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 15

Опубликована: Фев. 7, 2025

One lingering effect of the COVID-19 pandemic created by SARS-CoV-2 is emergence Long COVID (LC), characterized enduring neurological sequelae affecting a significant portion survivors. This review provides thorough analysis these disruptions with respect to cognitive dysfunction, which broadly manifest as chronic insomnia, fatigue, mood dysregulation, and impairments dysfunction. Furthermore, we characterize how diagnostic tools such PET, MRI, EEG, ultrasonography provide critical insight into subtle anomalies that may mechanistically explain disease phenotype. In this review, explore mechanistic hypotheses changes, describe CNS invasion, neuroinflammation, blood-brain barrier disruption, gut-brain axis along novel vascular disruption hypothesis highlights endothelial dysfunction hypoperfusion core underlying mechanism. We lastly evaluate clinical treatment landscape, scrutinizing efficacy various therapeutic strategies ranging from antivirals anti-inflammatory agents in mitigating multifaceted symptoms LC.

Язык: Английский

Процитировано

0
Increased Risk of Hospitalization for Various Disorders After COVID-19 Infection: A Cohort Study of the UK Biobank Spanning over a hundred Disease Categories DOI Creative Commons

Yong Xiang,

Ruoyu Zhang,

Jinghong Qiu

и другие.

Journal of Microbiology Immunology and Infection, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

COVID-19 is one of the most pressing public health issues worldwide. The sequelae however remains unclear. We performed a systematic assessment across all body systems, focusing on whether associated with increased risk hospitalization for various diseases. In this cohort study, we examined 135 disorders in UK biobank (UKBB) (N = 412,096; age: 50-87). also conducted analysis new-onset and recurrent cases, employed prior event rate adjustment (PERR) approach to minimize effects unmeasured confounders. Time-dependent were tested. Compared individuals no known history, those severe (hospitalized) exhibited hazards due multiple (median follow-up 261 days), including respiratory, cardiovascular, neurological, gastrointestinal, genitourinary, musculoskeletal as well injuries, infections non-specific symptoms. Notably, was risks 77 out 107 disease categories ≥ 5 events both groups. These results remained largely consistent sensitivity analyses. Mild (non-hospitalized) several disorders: aspiration pneumonitis, pain other general signs/symptoms. hospitalizations following infection generally higher during pre-vaccination era. This study revealed from wide variety pulmonary extra-pulmonary diseases after COVID-19, especially infections. findings may have important clinical implications, such need closer monitoring relevant sequelae, allocating more resources toward prevention treatment sequelae.

Язык: Английский

Процитировано

0
Assessing the impact of Long COVID on healthcare workers’ work – role functioning in tertiary hospitals in Singapore DOI Creative Commons
Zeenathnisa Mougammadou Aribou, Kian Wei Alvin Tan,

See Ming Lim

и другие.

Work, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Background Understanding Long COVID's impact on healthcare workers (HCWs) is vital for patient safety and care quality. However, research its prevalence among HCWs in Singapore work lacking. Objective This study aims to assess COVID role functioning two tertiary hospitals, filling a critical gap the literature. Methods Conducted from January April 2023, this evaluated HCWs’ work-role hospitals. over 21, having experienced ≥1 COVID-19 infection, participated an online survey. COVID, defined by NICE criteria, entailed symptoms persisting 4 or more weeks. Work-related was assessed using WRFQv2.0. Descriptive analyses were conducted STATA software. Results Out of 15,882 eligible participants, 573 responded (3.6% response rate). (symptoms ≥4 weeks) 47.5%, notably higher younger (<40 years old), those with moderate/severe infections, multiple infections. had significantly lower WRFQv2.0 mean scores compared without (85.1 vs. 74.3, p < 0.05). Additionally, ≥12 weeks than (85.6 Conclusion underscores potential functioning, especially prolonged symptoms. Tailored adjustments are crucial their successful return pre-illness levels, highlighting importance addressing settings.

Язык: Английский

Процитировано

0
Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection DOI Creative Commons
Jinlong Wang, Yibai Xiong, Zhiqi Song

и другие.

Animal Models and Experimental Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Abstract The World Health Organization has declared that COVID‐19 no longer constitutes a “public health emergency of international concern,” yet the long‐term impact SARS‐CoV‐2 infection on bone continues to pose new challenges for global public health. In recent years, numerous animal model and clinical studies have revealed severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can lead secondary osteoporosis. mechanisms involved are related virus's direct effects tissue, dysregulation body's inflammatory response, hypoxia, noncoding RNA imbalance, metabolic abnormalities. Although these unveiled connection between osteoporosis, current research is not comprehensive in depth. Future needed evaluate density metabolism, elucidate specific pathogenesis, explore potential interventions. This review aims collate existing literature infection‐induced summarize underlying mechanisms, provide direction future research.

Язык: Английский

Процитировано

0
Adult Long Coronavirus Disease 2019 DOI
Ivette F. Emery, Clifford J. Rosen

Infectious Disease Clinics of North America, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Long COVID and Associated Factors Among Chinese Residents Aged 16 Years and Older in Canada: A Cross-Sectional Online Study DOI Creative Commons
Matin Shariati,

Kieran Luke Gill,

Michael Peddle

и другие.

Biomedicines, Год журнала: 2025, Номер 13(4), С. 953 - 953

Опубликована: Апрель 13, 2025

As the COVID-19 pandemic evolved, long COVID emerged as a significant threat to public health, characterized by one or more persistent symptoms impacting organ systems beyond 12 weeks of infection. Informative research has been derived from assessments among Chinese populace. However, none these studies considered experience residents in Canada. Objectives: We aimed fill this literature gap delineating experience, prevalence, and associated factors sample residing Canada during pandemic. Methods: The present study employed cross-sectional online survey questionnaire distributed Canadian using convenience sampling procedure 22 December 2022 15 February 2023. Respondents were probed for sociodemographic background health-, COVID-, vaccine-related characteristics. Logistic LASSO regression was used model building, multivariate logistic identify with developing COVID. Results: Among 491 eligible participants, 63 (12.83%) reported experiencing mean duration 5.31 (95% CI: 4.06–6.57) months major including difficulty concentrating (21.67%), pain/discomfort (15.00%), well anxiety/depression (8.33%). Our final identified associations between two infections (OR = 23.725, 95% 5.098–110.398, p < 0.0001), very severe/severe 3.177, 1.160–8.702, 0.0246), over-the-counter medicine 2.473, 1.035–5.909, 0.0416), traditional 8.259, 3.016–22.620, 0.0001). Further, we protective effect good/good health status 0.247, 0.112–0.544, 0.0005). Conclusions: Long effected notable proportion prolonged period findings underscore importance preexisting reinfection prevention when managing Moreover, our work indicates an association Chinese.

Язык: Английский

Процитировано

0
Investigating viral and autoimmune T cell responses associated with post-acute sequelae of COVID-19 DOI
Gregory P. Williams, Esther Dawen Yu, K. I. Shapiro

и другие.

Human Immunology, Год журнала: 2024, Номер 85(3), С. 110770 - 110770

Опубликована: Март 2, 2024

Язык: Английский

Процитировано

3
Challenges and opportunities in long COVID research DOI
Rebecca E. Hamlin, Catherine A. Blish

Immunity, Год журнала: 2024, Номер 57(6), С. 1195 - 1214

Опубликована: Июнь 1, 2024

Язык: Английский

Процитировано

3
An updated meta-analysis of Chinese herbal medicine for the prevention of COVID-19 based on Western-Eastern medicine DOI Creative Commons

Siying Hu,

Dan Luo, Qikui Zhu

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 13, 2023

Background and aims: Chinese herbal medicine (CHM) was used to prevent treat coronavirus disease 2019 (COVID-19) in clinical practices. Many studies have demonstrated that the combination of CHM Western can be more effective treating COVID-19 compared alone. However, evidence-based on prevention undiagnosed or suspected cases remain scarce. This systematic review meta-analysis aimed investigate effectiveness preventing recurrent, new, diseases. Methods: We conducted a comprehensive search using ten databases including articles published between December September 2023. identify investigating use COVID-19. Heterogeneity assessed by random-effects model. The relative risk (RR) mean differences were calculated 95% confidence intervals (CI). modified Jadad Scale Newcastle-Ottawa (NOS) employed evaluate quality randomized controlled trials cohort studies, respectively. Results: Seventeen with total 47,351 patients included. Results revealed significantly reduced incidence (RR = 0.24, CI 0.11-0.53, p 0.0004), influenza 0.37, 0.18-0.76, 0.007), severe pneumonia exacerbation rate 0.17, 0.05-0.64, 0.009) non-treatment conventional control group. Evidence evaluation indicated moderate evidence for serum complement components C3 C4 trials. For RCTs as well ratio CD4+/CD8+ lymphocytes, low. remaining outcomes disappearance symptoms adverse reactions deemed very low quality. Conclusion: presents promising therapeutic option additional high-quality are needed further strengthen evidential integrity.

Язык: Английский

Процитировано

9