Non-targeted metabolomics-mediated elucidation of metabolite changes in Polygonatum kingianum during traditional steaming with black beans DOI Creative Commons

Haiyan Zhu,

Zhikun Pei, Lei Zhang

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 11, 2025

Polygonatum is a traditional medicinal and edible plant often prepared by steaming it with ingredients like yellow rice wine black beans. However, the metabolic changes in kingianum (PK) during method beans have not been previously reported. This study aims to explore how addition of degree affect quality PK. quantified polysaccharides, reducing sugars, saponins, flavonoids PK subjected varied cycles, while also integrating color measurement, sensory evaluation, non-targeted metabolomics analysis. rich lipids, amino acids, flavonoids, organic acids. Notably, we observed production significant accumulation daidzein daidzin (two primary active compounds derived from beans) as well triterpenoid saponins (including Sandosaponin A, Soyasaponin II-III, V, Pisumsaponin I-II) steamed (p < 0.05). After three multiple bioactive levels peaked or stabilized, which was consistent (score: 94/100). Compared raw PK, P3 stage exhibited increases total 21.29, 35.02, 49.13, 44.76%, respectively 0.05), sugars showed remarkable increase 160.94-fold 0.01), polysaccharides decreased significantly 43.33% 0.01). provides first evidence that can synergistically diversity isoflavones optimal achieved after rounds steaming. These findings validate scientific efficacy processing method. Our results advocate for continued use bean enhance nutritional health-promoting value providing template innovation herbal techniques based on auxiliary ingredients.

Язык: Английский

Modulatory effects of Aframomum melegueta and Rauvolfia vomitoria in cadmium-induced renal toxicity in adult rats DOI Creative Commons
Akinpelu Moronkeji, Temidayo Adeniyi,

Esan Olubunmi

и другие.

Journal of Cellular Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Background Cadmium, a nephrotoxic heavy metal, poses significant health risks that may be mitigated by the phytocompounds in ethnobotanicals like Aframomum melegueta and Rauvolfia vomitoria. Objective To evaluate modulatory potential of vomitoria on myeloperoxidase (MPO) nuclear factor kappa B (NF-Κβ) expression, alongside histomorphological changes cadmium chloride (CdCl 2 )-induced renal toxicity. Methods Twenty-five adult Wistar rats (200 g) were divided into five groups ( n = 7). Group I was control, while Groups II–V received CdCl (30 mg/kg BW, weekly). II no treatment; III IV administered extract BW daily), respectively. V both extracts daily). After 28 days, kidneys excised for histological mRNA expression NF-κB. Data analysed using one-way ANOVA, with p ≤ 0.05 considered significant. Results significantly repressed MPO NF-κB co-treatment exhibiting stronger downregulatory effect < 0.05). Histological analysis also showed improved architecture, as treatments histoarchitectural abnormalities observed cadmium-exposed untreated rats. Conclusion Findings suggest therapeutic effects mitigating cadmium-induced kidney

Язык: Английский

Процитировано

0
Hydrogen peroxide, central core of AgNP signaling pathway in promotion of saponins in Acanthophyllum squarrosum cells DOI

Sakineh Shakeri,

Somayeh Alikhani,

Mitra Jamshidi

и другие.

Plant Cell Tissue and Organ Culture (PCTOC), Год журнала: 2025, Номер 161(1)

Опубликована: Март 28, 2025

Язык: Английский

Процитировано

0
Plant-derived secondary metabolites against Bothrops envenomation: A review DOI
Mayara A. Romanelli,

Taissa Nunes Guerrero,

Elvis Lopes Brito

и другие.

Toxicon, Год журнала: 2025, Номер unknown, С. 108340 - 108340

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Green Approach for Pd-Catalyzed C–N Bond Formation with Weak Nitrogen Nucleophiles Using Saponin-Based Micellar Catalysis: Arylation of Anilines, Amides, Carbamates, Ureas, and Sulfonamides DOI
Vinothkumar Vinayagam, Subir Kumar Sadhukhan,

Dhurwasulu Baledi

и другие.

ACS Sustainable Chemistry & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Язык: Английский

Процитировано

0
Non-targeted metabolomics-mediated elucidation of metabolite changes in Polygonatum kingianum during traditional steaming with black beans DOI Creative Commons

Haiyan Zhu,

Zhikun Pei, Lei Zhang

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 11, 2025

Polygonatum is a traditional medicinal and edible plant often prepared by steaming it with ingredients like yellow rice wine black beans. However, the metabolic changes in kingianum (PK) during method beans have not been previously reported. This study aims to explore how addition of degree affect quality PK. quantified polysaccharides, reducing sugars, saponins, flavonoids PK subjected varied cycles, while also integrating color measurement, sensory evaluation, non-targeted metabolomics analysis. rich lipids, amino acids, flavonoids, organic acids. Notably, we observed production significant accumulation daidzein daidzin (two primary active compounds derived from beans) as well triterpenoid saponins (including Sandosaponin A, Soyasaponin II-III, V, Pisumsaponin I-II) steamed (p < 0.05). After three multiple bioactive levels peaked or stabilized, which was consistent (score: 94/100). Compared raw PK, P3 stage exhibited increases total 21.29, 35.02, 49.13, 44.76%, respectively 0.05), sugars showed remarkable increase 160.94-fold 0.01), polysaccharides decreased significantly 43.33% 0.01). provides first evidence that can synergistically diversity isoflavones optimal achieved after rounds steaming. These findings validate scientific efficacy processing method. Our results advocate for continued use bean enhance nutritional health-promoting value providing template innovation herbal techniques based on auxiliary ingredients.

Язык: Английский

Процитировано

0