Journal of Molecular Histology, Год журнала: 2024, Номер 56(1)
Опубликована: Дек. 14, 2024
Язык: Английский
Stresses, Год журнала: 2023, Номер 3(4), С. 785 - 812
Опубликована: Ноя. 29, 2023
Oxidative stress is caused by an imbalance between the production and subsequent accumulation of reactive oxygen species (ROS) in cells tissues capacity a biological system to eliminate these substances. Systemic oxidative biomarkers plasma, serum, urine, or red blood have been found be elevated many diseases, including skin cancer. UV radiation (UVR) induces damage biomolecules that enter bloodstream, reinforcing systemic stress. On other hand, pre-existing does not supply with adequate micronutrients antioxidant resources ameliorate skin’s defense against UVR. In both scenarios, cancer patients are exposed conditions. case warts, oxidation linked chronic inflammation, while impaired cutaneous could ineffectively deal possible stimuli from viral agents, such as HPV. Therefore, aim our study evaluate existing data on diseases non-melanoma (NMSC), basal-cell carcinoma (BCC), squamous-cell (SCC), melanoma well benign lesions actinic keratosis (AK), sebaceous (SK), warts. Previous studies demonstrated NMSC, melanoma, AK, warts (both genital non-genital) subjected severe stress, indicated disturbed enzyme levels, accumulated oxidized proteins lipid products, and, lesser extent, lower concentrations micronutrients. Interestingly, medical history NMSC stage treatment approach were affect parameters. non-genital), high levels also detected, they aligned their recalcitrant character.
Язык: Английский
Процитировано
12
Hormone and Metabolic Research, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 21, 2024
Abstract Diabetic nephropathy represents a predominant etiology of end-stage renal disease (ESRD) on global scale, significantly impacting the morbidity and mortality rates individuals with diabetes. The primary objective this analysis is to furnish comprehensive examination etiology, fundamental mechanisms, treatment modalities for DN. development DN stems from multitude factors, encompassing intricate interplay involving metabolic irregularities induced by hyperglycemia, alterations in hemodynamics, inflammatory responses, oxidative stress, genetic susceptibility. Principal mechanisms encompass generation advanced glycation end products (AGEs), activation protein kinase C (PKC), overexpression renin-angiotensin-aldosterone system (RAAS). These processes precipitate glomerular hyperfiltration, hypertrophy, eventually, fibrosis scarring parenchyma. Initially, hyperglycemia triggers mesangial proliferation thickening basement membrane incipient stages DN, subsequently leading progressive sclerosis tubulointerstitial fibrosis. Inflammatory cascades, notably cytokines like TGF-β NF-κB, play pivotal roles advancement fostering accumulation extracellular matrix Inflammation pathways, particularly those essential diabetic progression stimulating presence worsened dysfunctional mitochondria, contributes further injury via lipid peroxidation DNA damage. Current therapeutic approaches concentrate optimizing glycemic control, controlling hypertension, suppressing system. Among antihypertensive medications, ACE inhibitors angiotensin II receptor blockers are crucial decelerating advancement.
Язык: Английский
Процитировано
4
Frontiers in Endocrinology, Год журнала: 2025, Номер 15
Опубликована: Янв. 10, 2025
Oxidative stress is widely acknowledged as a key pathogenic mechanism in diabetic nephropathy (DN). In recent years, the role of oxidative DN has garnered increasing attention. However, no bibliometric analysis yet been conducted on relationship between and DN. This study aims to systematically analyze relevant literature, identify trends research, assess current hotspots, predict future directions. We retrieved literature related from Web Science Core Collection database. analyzed data publication volume, countries/regions, institutions, journals, keywords, other metrics using VOSviewer, Bibliometrix R package, CiteSpace. From 2014 2024, total 4076 publications were published across 755 showing consistent upward trend each year. China United States are leading contributors this field demonstrate close collaborative efforts. The top by country, institution, journal, author include: (1919 publications), Jilin University Central South (69 each), BIOMEDICINE & PHARMACOTHERAPY (117 Prof. Sun Lin (33 publications). most frequent keyword "oxidative stress" (3683 occurrences). co-citation analysis, Alicic RZ's 2017 was cited (144 citations). These findings highlight critical importance investigating pathogenesis perspective. demonstrates steady increase research since 2014, highlighting its central Future should focus molecular mechanisms explore therapeutic potential, provide new strategies for prevention treatment
Язык: Английский
Процитировано
0
Journal of Nutrition and Metabolism, Год журнала: 2025, Номер 2025(1)
Опубликована: Янв. 1, 2025
Tocotrienols, isomers of vitamin E, may provide an effective nutritional strategy to mitigate common cardiovascular risks such as dyslipidemia, inflammation, and oxidative stress in patients with chronic kidney disease (CKD). This double-blind, placebo-controlled, randomized clinical trial aimed evaluate the effects a tocotrienol-rich fraction (TRF) supplementation (300 mg/day) on inflammatory markers, including transcription factors nondialysis (ND) hemodialysis (HD) CKD for three months. Interleukin-6, tumor necrosis factor-α (IL-6 TNF-α), C-reactive protein (CRP), lipid peroxidation, biochemical parameters, NRF2 NF-κB mRNA expression were evaluated. Seventeen HD (9 placebo group, 8 TRF group) 16 ND (8 group completed study. In patients, significant reductions observed LDL cholesterol (p=0.04) total plasma levels (p=0.01) after intervention. CRP serum decreased significantly (p=0.05) supplementation. Transcription expressions remained unaltered both groups. study suggests that dyslipidemia involved increased risk, variations efficacy between patients. Trial Registration: ClinicalTrials.gov identifier: NCT04900532.
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2025, Номер 14(2), С. 130 - 130
Опубликована: Янв. 23, 2025
Diabetic nephropathy (DN) is a major cause of morbidity and mortality among patients with diabetes mellitus (DM). Studies have highlighted the critical role reactive oxygen species (ROS) in pathogenesis DM its complications. Apple polyphenol (AP) has demonstrated antioxidant properties various models. In this study, we investigated effects AP on DN rat model. Type 1 was induced Sprague–Dawley rats via single intraperitoneal injection streptozotocin (65 mg/kg) (n = 8). Rats blood glucose levels exceeding 250 mg/dL were treated at dosages 0.5%, 1%, or 2% (w/w) drinking water for 10 weeks. administration significantly improved early-stage markers, including reductions urea nitrogen-to-creatinine ratio urinary albumin-to-creatinine (ACR), dose-dependent manner. treatment also lowered triglyceride reduced lipid peroxidation kidney tissues. Histological analysis revealed that attenuated renal hydropic change, glomerular basement membrane thickening, restored mitochondrial morphology diabetic rats. Additionally, upregulation transforming growth factor-beta (TGF-β) observed by treatment. H2O2-stimulated mesangial cells, ROS levels, accompanied reduction TGF-β expression. These findings suggest exerts protective against improving function mitigating oxidative stress, indicating potential as nutraceutical supplement slowing progression.
Язык: Английский
Процитировано
0
Pharmacognosy Magazine, Год журнала: 2025, Номер unknown
Опубликована: Апрель 21, 2025
Background Diabetic nephropathy (DN) is a serious complication of both type 1 and 2 diabetes defined by progressive kidney damage and, ultimately, failure. The growing prevalence worldwide, coupled with lifestyle changes, has led to rise in the incidence DN, posing significant public health financial burden. Purpose This work aims assess therapeutic significance yangonin on DN an experimental rat model. Methods rats received 65 mg/kg streptozotocin (STZ) induce DN. were then treated for 12 weeks. After treatments had been completed, body weight changes blood glucose levels determined. dysfunction biomarkers, including creatinine, urea, uric acid, urea nitrogen (BUN), marker enzymes, assessed utilizing commercial assay kits. concentrations inflammatory cytokines oxidative stress-related biomarkers evaluated using renal tissues underwent histological study. Results treatment considerably elevated subsequent reduction rats. Furthermore, markers enzymes decreased effectively reduced response stress boosting anti-oxidant analysis results further confirmed efficacy against Conclusion current findings indicate that may mitigate rats, which highlights possesses potential serve as advantageous option
Язык: Английский
Процитировано
0
Pharmacology Research & Perspectives, Год журнала: 2025, Номер 13(3)
Опубликована: Апрель 22, 2025
ABSTRACT Diabetic nephropathy (DN) is a common complication of diabetes mellitus, with oxidative stress playing critical role in its development. Burdock fructooligosaccharide (BFO), major compound Burdock, exhibits antioxidative effects. However, mechanisms action and effects on diabetic are not clear enough. This study aims to explore the BFO impact streptozotocin‐induced mice. Male C57BL/6J mice were randomly divided into normal control, DN, groups. Relevant serum biochemical parameters detected using kits. Renal injury was evaluated through fluorescence microscopy, histopathology, transmission electron microscopy. Nrf2/HO‐1 signaling analyzed via quantitative real‐time PCR, western blotting, immunohistochemistry. In DN mice, significantly reduced fasting blood glucose, kidney index, urine protein, creatinine, urea nitrogen, total cholesterol, triglyceride, low‐density lipoprotein while increasing high‐density lipoprotein, SOD, CAT levels. Additionally, protected against renal injury, restored podocyte function, increased both mRNA protein expression Nrf2, HO‐1, Bcl‐2, decreased those Bax. conclusion, can be used treat promising candidate for treatment.
Язык: Английский
Процитировано
0
Journal of Pharmaceutical Research International, Год журнала: 2024, Номер 36(1), С. 13 - 30
Опубликована: Янв. 31, 2024
Background: Diabetes mellitus (DM) is often associated with oxidative stress (OS), which defined as an imbalance between the body's antioxidant defense systems and generation of reactive oxygen species (ROS). OS serves a crucial factor in intricate relationship DM cellular dysfunction, influencing ROS subsequent complications such retinopathy, cardiomyopathy, neuropathy, nephropathy, encephalopathy, peripheral arteriopathy. Objective: This comprehensive review aims to elucidate complex interplay DM, providing thorough understanding underlying mechanisms highlighting emerging therapeutic interventions for management OS-related DM. It also explores novel antioxidant-based therapies aiming at specific markers developing personalized interventions, represents promising avenue enhancing treatment efficacy DM. Method: The search was conducted on scientific databases web portals PubMed, ScienceDirect, Web Science, Embase, Google Scholar, EBSCO, DOAJ, etc. Conclusion: In conclusion, are related through dynamic interaction involving genetic, molecular, environmental variables. Interdisciplinary approaches hold potential uncover biomarkers early detection, prognosis, oriented thereby revolutionizing clinical DM-related complications. With research continuing advance customized treatments being more widely incorporated into practice, there hope that impact will be significantly mitigated future. Despite notable progress, certain unexplored facets necessitate deeper investigations precise exacerbates progression
Язык: Английский
Процитировано
3
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Дек. 18, 2024
Diabetes is a complex condition with rising global incidence, and its impact equally evident in pediatric practice. Regardless of whether we are dealing type 1 or 2 diabetes, the development complications following onset disease inevitable. Consequently, contemporary medicine must concentrate on understanding pathophysiological mechanisms driving systemic decline finding ways to address them. We particularly interested effects oxidative stress target cells organs, such as pancreatic islets, retina, kidneys, neurological cardiovascular systems. Our goal explore, using latest data from international scientific databases, relationship between persistence damage associated diabetes children. Additionally, highlight beneficial roles antioxidants vitamins, minerals, polyphenols, other bioactive molecules; mitigating pathogenic cascade, detailing how they intervene their properties. As result, our study provides comprehensive exploration key aspects stress-antioxidants-pediatric triad, expanding significance various diseases.
Язык: Английский
Процитировано
3
Journal of Pharmaceutical and Biomedical Analysis, Год журнала: 2024, Номер 243, С. 116072 - 116072
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
0