Exploring the multiple therapeutic mechanisms and challenges of mesenchymal stem cell-derived exosomes in Alzheimer's disease

BioScience Trends, Год журнала: 2024, Номер 18(5), С. 413 - 430

Опубликована: Окт. 10, 2024

Alzheimer's disease (AD) is a severe neurodegenerative disorder, and the current treatment options are limited. Mesenchymal stem cell-derived exosomes (MSC-Exos) have garnered significant attention due to their unique biological properties, showcasing tremendous potential as an acellular alternative therapy for AD. MSC-Exos exhibit excellent biocompatibility low immunogenicity, enabling them effectively cross blood-brain barrier (BBB) deliver therapeutic molecules directly target cells. They highly efficacious in delivering nucleic acid-based drugs. Moreover, production process of benefits from high proliferation capacity multilineage differentiation potential, allowing while maintaining stable composition. Despite theoretical advantages MSC-Exos, clinical use still faces multiple challenges, including cross-contamination during isolation purification processes, complexity components, presence adverse paracrine factors. Future research needs focus on optimizing separation techniques, enhancing delivery methods improve efficacy, performing detailed analyses components MSC-Exos. In summary, hold promise effective option AD other diseases, driving related fields.

Язык: Английский

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Mechanisms of the Pathogenesis of Alzheimer’s Disease: The Role of the Basal Forebrain

Neuroscience and Behavioral Physiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Язык: Английский

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TGN peptide and erythrocyte membrane dual-modified selenium-doped carbon quantum dots for multifaceted treatment of Alzheimer’s disease

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163340 - 163340

Опубликована: Май 1, 2025

Язык: Английский

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Revolutionizing neurotherapeutics: Nanocarriers unveiling the potential of phytochemicals in Alzheimer's disease

Neuropharmacology, Год журнала: 2024, Номер 259, С. 110096 - 110096

Опубликована: Июль 29, 2024

Neurological disorders pose a huge worldwide challenge to the healthcare system, necessitating innovative strategies for targeted drug delivery central nervous system. Alzheimer's disease (AD) is an untreatable neurodegenerative condition characterized by dementia and alterations in patient's physiological mental states. Since ancient times, medicinal plants have been important source of bioactive phytochemicals with immense therapeutic potential. This review investigates new safer alternatives prevention treatment related inevitable side effects associated synthetic compounds. examines how nanotechnology can help enhancing neuroprotective AD. Nevertheless, despite their remarkable properties, these natural products often poor efficacy due low bioavailability, limited solubility imperfect blood brain barrier (BBB) penetration. Nanotechnology produces personalized systems which are necessary solving such problems. In overcoming challenges, might be employed as way forward whereby customized medication would established result. The use nanocarriers design application highlighted this review, indicate potential revolutionizing delivery. We also explore complications possibilities using supply nutraceuticals improve patients' standard living, preclinical well clinical investigations displaying that techniques effective mitigating diseases. order fight diseases health, scientists doctors employ its possible interventions.

Язык: Английский

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Ferroptosis in Neurons: A Bibliometric Analysis of Research Trends, Key Contributions, and Emerging Directions

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Background Neurons are the fundamental structural and functional units of nervous system, serving as core cells for information transmission regulation. They closely associated with various neurological diseases. Recent studies have shown significant advancements in research on ferroptosis neurons; however, there has been a lack bibliometric analysis this field. This study aims to provide comprehensive overview knowledge structure related neurons through methods, identify current trends hotspots, predict potential future directions. Methods We conducted search publications from 2014 2024 Web Science Core Collection (WoSCC) database. Bibliometric methods were employed analyze authors, institutions, countries, journals, references using VOSviewer, CiteSpace, R package "bibliometrix". Results included 685 articles 50 China United States being leading contributors. The number year-on-year increase. primary institutions Central South University, Harbin Medical University Melbourne. Free Radical Biology Medicine is most popular journal field, while Cell highest citation count. A total 4,673 authors contributed research, David Devos Ashley I. Bush having publications, Scott J. Dixon had co-citations. Keyword revealed that molecular mechanisms its application diseases focuses Conclusion first summarizing developments neurons. outlines predicts global hotspots trends, providing valuable scholars studying ferroptosis.

Язык: Английский

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Meroterpenoids from Terrestrial and Marine Fungi: Promising Agents for Neurodegenerative Disorders—An Updated Review

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(2), С. 96 - 96

Опубликована: Фев. 3, 2025

Background: Meroterpenoids represent a remarkably diverse class of natural secondary metabolites, some which are synthesized via terpenoid biosynthetic pathways. Over the past ten years, these compounds have gained interest because their wide range biological activities, such as anti-cholinesterase, COX-2 inhibitory, antibacterial, antiviral, antidiabetic, antioxidant, anti-inflammatory, antineoplastic, and cardioprotective properties. This review aims to consolidate recognized neuroprotective effects meroterpenoids from marine terrestrial fungi. Methods: Data compiled several databases, including PubMed, Science Direct, Scopus, Google Scholar, include articles published since 2000 using keywords “neuroprotective”, “fungi”, “mushroom”, “marine sponge”, “neurodegeneration”, “dementia” in connection with “meroterpenoids”. Results: modulate different cell signaling pathways exhibit often combined mechanisms action ameliorate neuronal damage dysfunction. Reported activities BACE1 inhibition, anti-inflammatory all potential treatment dementia associated neurodegenerative diseases Alzheimer’s Parkinson’s. Conclusions: be developed effective tools for neuropathological diseases. Ongoing research elucidate various remains essential requires further investigation.

Язык: Английский

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Implications of Mucin-Type O-Glycosylation in Alzheimer’s Disease

Molecules, Год журнала: 2025, Номер 30(9), С. 1895 - 1895

Опубликована: Апрель 24, 2025

Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders linked to aging. Major hallmarks AD pathogenesis include amyloid-β peptide (Aβ) plaques, which are extracellular deposits originating from processing amyloid precursor protein (APP), and neurofibrillary tangles (NFTs), intracellular aggregates tau protein. Recent evidence indicates that disruptions in metal homeostasis impaired immune recognition these trigger neuroinflammation, ultimately driving progression. Therefore, a more comprehensive approach needed understand underlying causes disease. Patients with present abnormal glycan profiles, known AD-related molecules either modified glycans or involved regulation. A deeper understanding how O-glycosylation influences balance between amyloid-beta production clearance, as well microglia’s pro- anti-inflammatory responses, crucial for deciphering early pathogenic events AD. This review aims provide summary extensive research conducted on role mucin-type AD, discussing its onset recognition.

Язык: Английский

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Therapeutic Potential of Dual HDAC6/SIRT2 Inhibition in Alzheimer’s Disease

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 294, С. 117733 - 117733

Опубликована: Май 9, 2025

Язык: Английский

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Apolipoprotein E genotype as a biomarker in late-onset Alzheimer’s disease: A narrative review of the influence of genetic factors on molecular structure

NeuroMarkers., Год журнала: 2025, Номер 2(3), С. 100095 - 100095

Опубликована: Май 19, 2025

Язык: Английский

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Mechanism of Rhizoma Polygonati in the treatment of Alzheimer’s disease based on network pharmacology and molecular docking

Brain Research, Год журнала: 2025, Номер unknown, С. 149680 - 149680

Опубликована: Май 1, 2025

Язык: Английский

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