Critical review and future perspectives on the anticancer effects of Stephania tetrandra S. Moore
Phytochemistry Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Язык: Английский
Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic–clonic seizure model: an isobolographic transformation
Pharmacological Reports,
Год журнала:
2023,
Номер
75(6), С. 1533 - 1543
Опубликована: Окт. 11, 2023
Abstract
Background
Overwhelming
evidence
indicates
that
some
naturally
occurring
coumarins
and
terpenes
are
widely
used
in
folk
medicine
due
to
their
various
therapeutic
effects
affecting
the
brain.
Antiseizure
medications
(ASMs)
principal
treatment
option
for
epilepsy
patients,
although
novel
strategies
based
on
substances
intensively
investigated.
This
study
was
aimed
at
determining
influence
of
isopimpinellin
(ISOP—a
coumarin)
when
administered
either
separately
or
combination
with
borneol
(BOR—a
monoterpenoid),
antiseizure
potencies
four
classic
ASMs
(carbamazepine
(CBZ),
phenytoin
(PHT),
phenobarbital
(PB),
valproate
(VPA))
mouse
model
maximal
electroshock-induced
(MES)
tonic–clonic
seizures.
Materials
Tonic–clonic
seizures
were
evoked
experimentally
mice
after
systemic
(
ip
)
administration
respective
doses
ISOP,
BOR,
ASMs.
Interactions
two-drug
(ISOP
+
a
ASM)
three-drug
BOR
mixtures
assessed
isobolographically
MES
model.
Results
ISOP
(administered
alone)
had
no
impact
anticonvulsant
Due
isobolographic
transformation
data,
VPA
exerted
an
antagonistic
interaction,
whereas
CBZ,
PHT,
PB
produced
additive
interactions
The
combinations
CBZ
PHT
interactions,
while
synergistic
Conclusions
most
intriguing
interaction
VPA,
which
addition
transition
from
antagonism
synergy
Язык: Английский
Optimized Centrifugal Partition Chromatography (CPC) Protocol for Isolation of Urease Inhibitors: Magnoflorine and Berberine from Berberis vulgaris Extracts
Separations,
Год журнала:
2024,
Номер
11(4), С. 94 - 94
Опубликована: Март 25, 2024
In
recent
years,
an
increasing
interest
in
phytotherapy
has
been
observed.
Parallel
to
the
research
on
total
extracts
of
plant
material,
numerous
studies
activity
single
molecules
derived
from
plants
are
being
conducted
address
their
mechanisms
action
and
determine
active
doses
eventual
interactions.
Despite
this
phenomenon,
isolation
individual
compounds
is
a
bottleneck
due
its
difficulty
cost.
This
work
presents
results
careful
optimization
magnoflorine
berberine
(isoquinoline
alkaloids)
recovery
commonly
distributed
shrub,
Berberis
vulgaris,
growing
Poland
Georgia,
using
CPC.
Both
known
for
medicinal
properties,
which
makes
methodology
important
area
research.
Additionally,
CPC
ability
isolate
high-quality
large
quantities,
it
effective
easy-to-commercialize
method.
For
successful
separation,
biphasic
solvent
system
composed
hexane,
butanol,
ethanol,
water
ratio
(3:12:4:16
v/v/v/v)
was
used
ascending
mode,
together
with
flow
rate
8
mL/min
rotation
speed
1600
rpm.
The
method
selective
both
compounds,
delivered
good
root
stem
plant.
qualitative
composition
alkaloids
studied
determined
by
HPLC-ESI-QTOF-MS/MS
confirmed
presence
berberine,
magnoflorine,
jatrorhizine,
palmatine
group
isoquinolines.
isolates,
were
subjected
Helicobacter
pylori
growth
inhibition
assay
urease
test
assess
whether,
next
previously
proved
anticancer
these
characterized
H.
inhibition.
MGN
found
exhibit
inhibitory
potential
against
(IC50
=
25
mg/L).
Язык: Английский