Antioxidant insights: investigating the protective role of oxidative balance in inflammatory bowel disease
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Май 31, 2024
Background
Limited
studies
have
investigated
the
relationship
between
systemic
oxidative
stress
and
inflammatory
bowel
disease
(IBD).
The
purpose
of
this
study
was
to
explore
balance
score
(OBS)
IBD.
Methods
We
included
175,808
participants
from
UK
Biobank
database
2006
2010.
OBS
scores
were
calculated
based
on
22
lifestyle
dietary
factors.
Multiple
variable
Cox
proportional
regression
models,
as
well
gender
stratification
subgroup
analysis,
utilized
investigate
Results
There
is
a
significant
negative
correlation
occurrence
IBD,
ulcerative
colitis
(UC),
Crohn’s
(CD).
Additionally,
significantly
negatively
correlated
with
intestinal
obstruction
in
CD
patients.
Gender
stratified
analysis
suggest
female
patients,
particularly
pronounced
those
under
60
years
old.
Sensitivity
indicates
lifestyle-related
diet-related
females,
males.
Conclusion
showed
especially
This
underscores
importance
antioxidant
diet
lifestyle,
which
may
provide
greater
advantage
for
Язык: Английский
Environmental Pollution by Ozone, Oxidative Stress: the Relationship between the Intestine and Neurodegenerative Disease
Опубликована: Май 8, 2023
Repeated
exposure
to
environmental
ozone
causes
a
chronic
state
of
oxidative
stress.
This
is
present
in
degenerative
diseases
and
induces
loss
control
the
inflammatory
response.
The
dysfunction
redox
system
failures
responses
are
involved
vicious
circle
that
maintains
increases
process.
Intestine
also
responds
secondary
reactive
species
formed
by
doses,
generating
noxious
stimuli
increase
damage.
review
aims
elucidate
how
pollution,
mainly
ozone,
stress
with
regulation
response,
both
intestine
brain,
where
functionality
structures
altered
plays
determining
role
some
neurodegenerative
diseases.
For
this
purpose,
we
searched
for
information
on
sites
like
Cochrane
Library
Database,
PubMed,
Scopus,
Medscape.
Reviewing
data
published,
can
conclude
pollutants
severe
health
problem.
Ozone
pollution
has
different
pathways
action,
molecular
systemic,
participates
such
as
Parkinson's
Alzheimer's
disease
well
bowel
Inflammatory
Bowel
Disease,
Crohn's
Disease
Irritable
Syndrome.
Язык: Английский
G0S2 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell injury by regulating mitochondrial apoptosis
Annals of Translational Medicine,
Год журнала:
2022,
Номер
10(24), С. 1383 - 1383
Опубликована: Дек. 1, 2022
Oxidative
low-density
lipoprotein
(ox-LDL)-induced
endothelial
cell
damage
is
a
major
risk
factor
for
atherosclerosis
and
its
related
cardiovascular
diseases.
The
G0/G1
switch
gene
2
(G0S2)
multifunctional
protein
which
has
been
poorly
studied
in
atherosclerosis.In
this
study,
ox-LDL
was
utilized
to
construct
human
aortic
(HAEC)
injury
model.It
found
that
impaired
viability,
augmented
lactate
dehydrogenase
(LDH)
release,
reduced
G0S2
levels
HAECs
dose-dependent
manner.
Further,
overexpression
improved
the
viability
restrained
apoptosis
of
treated
by
ox-LDL.
Conversely,
depletion
decreased
aggravated
At
molecular
level,
significantly
increased
secretion
superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
peroxidase
(GPH-Px),
promoted
intracellular
reactive
oxygen
species
(ROS)
production
malondialdehyde
(MDA)
content
under
either
normal
or
conditions.
Meanwhile,
ox-LDL-induced
mitochondrial
dysfunction,
as
demonstrated
membrane
potential,
translocation
cytochrome
c
(Cyt-c)
cytoplasm,
activation
caspase-3
caspase-9,
reversed
overexpression.
In
addition,
AMP-activated
kinase
(AMPK)
expression
nuclear
erythroid-2-related
factor-2
(Nrf2),
sirtuin
1
(SIRT1)
heme
oxygenase
(HO-1)
conditions.This
study
protects
against
vascular
regulating
oxidative
homeostasis
may
be
promising
target
treatment
atherosclerosis.
Язык: Английский
Comparison of Serum Albumin Level in Stable & Hospitalized Patients of Chronic Obstructive Pulmonary Diseases (COPD)
Опубликована: Окт. 30, 2022
Objective:
This
study
was
conducted
to
estimate
the
serum
albumin
levels
in
stable
&
hospitalized
patients
of
COPD.
Study
Design:
Comparative
Cross
Sectional
Place
and
Duration
Study:
jointly
carried
out
at
Pulmonology
Shaikh
Zyed
Hospital
Rahim
Yar
Khan,
Fatima
Jinnah
Institute
Chest
Medicine
Quetta
Liaquat
University
medical
health
sciences,
Jamshoro
from
1st
January
2021
December
2021.
Methodology:
A
total
180
cases
COPD
were
selected
divided
into
two
groups;
group
contained
95
as
cases,
B
included
85
with
mentioned
inclusion
exclusion
criteria.
The
level
estimated
by
bromocresol
green
(BCG)
method.
less
than
3.2
g/dl
is
considered
hypoalbumienimia.
statistical
data
analysed
SPSS
version
22
applying
an
independent
student
T
test.
Results:
mean
3.0
±
0.41
while
it
2.6
0.34
g/dl.
statistically(P
<0.001)
declined
compared
Conclusion:This
concluded
that
severity
directly
proportional
reduction
Keywords:
COPD,
Serum
Albumin,
Oxidative
Stress,
Inflammatory
mediators
Язык: Английский