Oversecretion of CCL3 by Irradiation-Induced Senescent Osteocytes Mediates Bone Homeostasis Imbalance
Cells,
Год журнала:
2025,
Номер
14(4), С. 249 - 249
Опубликована: Фев. 10, 2025
Various
stressors
such
as
ionizing
radiation
(IR),
chemotherapeutic
agents,
oxidative
stress,
and
inflammatory
responses
can
trigger
the
stress-induced
premature
senescence
(SIPS)
of
cells
in
bone
microenvironment,
including
osteocytes.
However,
little
is
known
about
mechanisms
underlying
senescent
cellular
regulation
differentiation
potential
homeostasis.
Here,
we
report
a
secretory
change
osteocytes
activated
by
IR,
its
subsequent
impact
on
osteogenic
osteoclastic
differentiation,
cascade
response.
It
was
observed
that
exhibited
altered
biological
function,
persistent
incomplete
DNA
damage
repair,
characteristic
phenotypes
after
exposure
to
IR
vitro.
Meanwhile,
concomitant
increase
CC
chemokine
ligand
3
(CCL3),
key
component
senescence-associated
phenotype
(SASP),
IR-induced
osteocytes,
which
could
further
downregulate
enhance
cell
supernatant
co-culture
experiments.
Notably,
enhancement
PI3K/Akt/NF-κB
signaling
pathway
appears
be
an
essential
driver
imbalance
between
potentials.
Taken
together,
these
data
suggest
novel
role
CCL3
homeostatic
through
SASP
secretion,
mediated
pathway.
Язык: Английский
Advances in Molecular Research on Hip Joint Impingement—A Vascular Perspective
Biomolecules,
Год журнала:
2024,
Номер
14(7), С. 784 - 784
Опубликована: Июнь 30, 2024
With
the
rise
in
longevity
within
population,
medicine
continues
to
encounter
fresh
hurdles
necessitating
prompt
actions,
among
which
are
those
associated
with
hip
joint
aging.
Age-related
arthropathies
encompass
damage
bones'
articulating
extremities
and
their
supporting
structures,
such
as
articular
cartilage,
alterations
quantity
quality
of
synovial
fluid.
This
study
aims
summarize
biomolecular
methods
evaluation
focused
on
its
vascularization,
using
data
correlated
research
other
joints
tissues,
order
reach
an
objective
opinion
prospects
this
field.
Following
a
retrospective
most
modern
synovium,
capsule,
cartilage
joint,
we
have
hereby
concretized
certain
future
directions
field
that
will
improve
qualitative
morphofunctional
management
at
advanced
age,
even
population
categories
risk
developing
various
degenerative
pathologies.
Язык: Английский