The Impact of Gut Microbiota on Long COVID: Insights and Challenges. DOI Open Access
Irami Araújo-Filho, Amália Cínthia Meneses do Rêgo

JOURNAL OF SURGICAL AND CLINICAL RESEARCH, Год журнала: 2024, Номер 15(1), С. 37 - 43

Опубликована: Июль 8, 2024

Long COVID-19, characterized by persistent symptoms following acute COVID-19 infection, presents a multifaceted challenge. Recent research has unveiled the potential role of gut microbiota in shaping course COVID, offering insights into its consequences and therapeutic avenues. Dysbiosis microbiota, marked reduction beneficial commensal bacteria an increase pro-inflammatory taxa, appears to be common feature Long-term COVID patients. Notably, composition correlates with symptom severity duration, suggesting link between microbiome COVID's clinical manifestations. Various interventions, such as antibiotics, probiotics, dietary modulation, have been explored strategies mitigate dysbiosis effects on COVID-19. Parallels myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) drawn, indicating shared mechanisms, including involvement. Longitudinal studies highlight persistence alterations beyond phase emphasizing need for long-term monitoring interventions. While these findings offer promise, standardized comprehensive is essential establish causality elucidate intricate mechanisms underlying microbiota's influence COVID. Understanding this relationship holds develop novel approaches managing improving outcomes, addressing pressing public health concern.

Язык: Английский

The Potential Role of Mitochondria in the Microbiota-Gut-Brain Axis: Implications for Brain Health DOI Creative Commons
Lei Qiao, Ge Yang, Peng Wang

и другие.

Pharmacological Research, Год журнала: 2024, Номер 209, С. 107434 - 107434

Опубликована: Сен. 25, 2024

Mitochondria are crucial organelles that regulate cellular energy metabolism, calcium homeostasis, and oxidative stress responses, playing pivotal roles in brain development neurodegeneration. Concurrently, the gut microbiota has emerged as a key modulator of physiology pathology through microbiota-gut-brain axis. Recent evidence suggests an intricate crosstalk between mitochondrial function, mediated by microbial metabolites can influence activities brain. This review aims to provide comprehensive overview emerging role mitochondria critical mediators axis, shaping health neurological disease pathogenesis. We discuss how such short-chain fatty acids, secondary bile tryptophan metabolites, trimethylamine N-oxide traverse blood-brain barrier modulate processes including production, regulation, mitophagy, neurons glial cells. Additionally, we proposed targeting diet, prebiotics, probiotics, or promising potential therapeutic approach maintain optimizing fitness. Overall, further investigations into its bioenergetics, dynamics, responses will valuable insights axis both states.

Язык: Английский

Процитировано

5
Fighting Cancer with Photodynamic Therapy and Nanotechnologies: Current Challenges and Future Directions DOI Open Access
Laura Marinela Ailioaie, Constantin Ailioaie, Gerhard Litscher

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2969 - 2969

Опубликована: Март 25, 2025

Photodynamic therapy (PDT) is an innovative treatment that has recently been approved for clinical use and holds promise cancer patients. It offers several benefits, such as low systemic toxicity, minimal invasiveness, the ability to stimulate antitumor immune responses. For certain types of cancer, it shown positive results with few side effects. However, PDT still faces some challenges, including limited light penetration into deeper tumor tissues, uneven distribution photosensitizer (PS) can also affect healthy cells, difficulties posed by hypoxic microenvironment (TME). In conditions, PDT's effectiveness reduced due insufficient production reactive oxygen species, which limits destruction lead relapse. This review highlights recent advances in photosensitizers nanotechnologies are being developed improve PDT. focuses on multifunctional nanoplatforms nanoshuttles have preclinical studies, especially treating solid tumors. One key areas focus development PSs specifically target mitochondria treat deep-seated malignant New mitochondria-targeting nano-PSs designed better water solubility extended wavelength ranges, allowing them tumors more effectively, even challenging, environments. These advancements opening new doors treatment, when combined other therapeutic strategies. Moving forward, research should optimizing PDT, creating efficient drug delivery systems, developing smarter platforms. Ultimately, these efforts aim make a first-choice option

Язык: Английский

Процитировано

0
SARS-CoV-2 Infection and Multiple Sclerosis: Proactive Approach in a Vulnerable Patient Group through Daily Vitamin D Supplementation? DOI Creative Commons

Hans Goischke,

K. Hans

Опубликована: Фев. 10, 2024

VitD deficiency-risk factor pathologyHans-Klaus Goischke (2024) SARS-CoV-2 Infection and Multiple Sclerosis: Proactive Approach in a Vulnerable Patient Group through Daily Vitamin D Supplementation?rate was significantly lower than with values below or deficiency [17].Current data suggest protective role for VitD, particularly risk of intensive care unit admission reduced death [18,19].In addition, the occurrence Long-Covid is an aspect implementing this simple, effective, safe costeffective therapy broad therapeutic window prevention treatment .Although there still no indisputable evidence that Vit supplementation (VitD suppl.)reduces SARSCov-2 infection healthy individuals, collective it benefits vulnerable individuals [23].PwMS comorbidities, psychiatric illnesses, hypertension, obesity (an increased BMI may correlate severe course Covid-19), age > 50 years, disability methylprednisolone boost as well some DMTs (disease-modifying therapies) have higher COVID-19 courses [24-26].Infections (SARS-COV-2) can increase MS symptoms (pseudo-relapses) cause real relapses [27].In post-COVID syndrome (Long Covid), one eight patients presents such fatigue, shortness breath, cough, joint pain, chest muscle headache paresthesia limbs after at least 3 months.The latter also occur PwMS per se [28,29].If vitamin administration results infection, severity illness to people risk, occurs less frequently [18,19,21,22,30-33], not ethically justifiable withhold high dose vitamin-D from risk. Mechanisms Action COVID-19Barrea et al. list detail 14 mechanisms described by suppl. be sufficient Covid 19 vaccination supported [19,29,32,[34][35][36][37][38].Vit its metabolites inactivate viruses (increase antimicrobial peptide cathelicidin, defensins), lead reduction cytokine storm, reduce matrix metalloproteinase-9 concentration thereby host's metabolic tolerance damage, pneumonia myocarditis, pro-inflammatory cytokines, especially interleukin 6 (IL-6), which promotes permeability BBB, leads potentiation CNS damage PwMS, serious [29,[39][40][41][42]. enables neuroprotection reducing inflammation oxidative stress.Low 25(OH)D levels were inversely correlated IL-6 independent predictors mortality [43].1,25(OH)2D3 inhibits immunoglobulin synthesis, regulates B cell activity reduces auto-Ab production.It converts cells into plasma [18].Vit EBV [29].Current studies show chronic Long Covid-19 reactivation latent Epstein-Barr virus (EBV) worsening health status [44-48].In MS, level molecular mimicry between transcription EBNA-1 protein GlialCAM (glial adhesion molecule central nervous system [49].Bernal able detect detecting DNA antibodies against EBV-lytic genes [50].

Язык: Английский

Процитировано

1
Modulatory role of Faecalibacterium on insulin resistance and coagulation in patients with post-viral long haulers depending on adiposity DOI Creative Commons
Amanda Cuevas‐Sierra, Lourdes Chero‐Sandoval, Andrea Higuera‐Gómez

и другие.

iScience, Год журнала: 2024, Номер 27(8), С. 110450 - 110450

Опубликована: Июль 6, 2024

Patients with Post-viral long hauler encompass lasting symptoms and comorbid complexities, often exacerbated in individuals excessive body weight. The aim was to study gut microbiota 130 patients post-viral stratified by mass index (BMI) the relationship between inflammation microbiota. Significant higher values were found for anthropometric variables markers of glucose dyslipidemia BMI, as well elevated levels C-reactive protein, fibrinogen, IL-6, uric acid, D-dimer. An interactive association showed an interplay Faecalibacterium, D-dimer levels, insulin resistance. This investigation that anthropometric, biochemical, inflammatory impaired haulers BMI. In addition, differences groups a modification effect on Faecalibacterium abundance regarding resistance These findings suggest considering adiposity structure composition may improve personalized clinical interventions chronic inflammation.

Язык: Английский

Процитировано

1
The Interplay of Microbiota, Long COVID, and Musculoskeletal Pain: A Narrative Review DOI Creative Commons
Leila Simorgh, Rozita Hedayati,

Mina Sadat Mirshoja

и другие.

Deleted Journal, Год журнала: 2024, Номер 1(2)

Опубликована: Сен. 1, 2024

Context: Long COVID, a condition that persists after the acute phase of COVID-19, poses significant burden, with 10 - 45% recovered patients experiencing persistent symptoms. Among these, approximately 46% report musculoskeletal pain. This narrative review explores potential connections between gut microbiota, and pain, aiming to introduce new therapeutic avenues preventive strategies for managing symptoms in COVID patients. Evidence Acquisition: A comprehensive search was conducted using Google Scholar, Lens.org, ConnectedPaper.com identify relevant articles published 2019 2024. Keywords related pain were used. Articles selected based on predefined inclusion exclusion criteria, their quality assessed. Data from synthesized provide an overview interplay Results: Recent research highlights role microbiota modulating immune responses systemic inflammation. Dysbiosis has been linked severity progression COVID-19 persistence Individuals often experience new-onset manifestations, such as joint myalgia, chronic Additionally, dysbiosis associated conditions like lower back knee osteoarthritis. suggests relationship problems general may also extend patients, indicating broader implications outcomes. Therapeutic targeting probiotics, prebiotics, dietary interventions, have shown promise these improving overall health Conclusions: The evidence underscores importance understanding microbiota-musculoskeletal nexus COVID. Gut contributes inflammation, exacerbating associations other emphasize need microbiota-targeted strategies. Future should focus elucidating mechanisms linking exploring gut-brain axis, developing personalized approaches modulate microbiota. Advancing our this can pave way innovative address complex challenges posed by conditions.

Язык: Английский

Процитировано

1
Letter to the editor: Efficacy of probiotic treatment as postexposure prophylaxis for COVID-19: A double-blind, PlaceboControlled randomized trial DOI

Yuan Ji,

Jinhan Chen,

Yuying Chi

и другие.

Clinical Nutrition, Год журнала: 2024, Номер 43(6), С. 1501 - 1502

Опубликована: Май 7, 2024

Язык: Английский

Процитировано

0
The Impact of Gut Microbiota on Long COVID: Insights and Challenges. DOI Open Access
Irami Araújo-Filho, Amália Cínthia Meneses do Rêgo

JOURNAL OF SURGICAL AND CLINICAL RESEARCH, Год журнала: 2024, Номер 15(1), С. 37 - 43

Опубликована: Июль 8, 2024

Long COVID-19, characterized by persistent symptoms following acute COVID-19 infection, presents a multifaceted challenge. Recent research has unveiled the potential role of gut microbiota in shaping course COVID, offering insights into its consequences and therapeutic avenues. Dysbiosis microbiota, marked reduction beneficial commensal bacteria an increase pro-inflammatory taxa, appears to be common feature Long-term COVID patients. Notably, composition correlates with symptom severity duration, suggesting link between microbiome COVID's clinical manifestations. Various interventions, such as antibiotics, probiotics, dietary modulation, have been explored strategies mitigate dysbiosis effects on COVID-19. Parallels myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) drawn, indicating shared mechanisms, including involvement. Longitudinal studies highlight persistence alterations beyond phase emphasizing need for long-term monitoring interventions. While these findings offer promise, standardized comprehensive is essential establish causality elucidate intricate mechanisms underlying microbiota's influence COVID. Understanding this relationship holds develop novel approaches managing improving outcomes, addressing pressing public health concern.

Язык: Английский

Процитировано

0