Unravelling the potential of yolkin for nutraceutical use: the origin, structure, and functional insights of a hen egg yolk polypeptide complex
Food & Function,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Nutraceuticals
can
reduce
the
risk
of
many
diseases,
such
as
cardiovascular
disease,
immune
deficiencies,
neurodegeneration,
and
others.
Their
delivery
remains
a
challenge
because
it
depends
on
factors,
most
notably
stability
bioactive
compounds.
Yolkin
is
peptide
complex
isolated
from
hen
egg
yolk
with
immunomodulatory
neuroprotective
potential.
However,
yolkin
relatively
poorly
characterized.
We
aimed
to
determine
origin
glycosylation
level
yolkin,
its
storage
conditions,
thermal
stability,
aggregation
ability
assess
antioxidant,
antihypertensive,
antidiabetic
The
composition
was
shown
be
homologous
that
vitellogenin
II
I.
These
results
indicate
in
lyophilized
form,
preferably
at
4
°C,
nonaggregation,
activities.
As
result,
considered
have
significant
therapeutic
potential
represents
valuable
tool
for
development
novel
nutraceuticals.
Язык: Английский
Age-Dependent Effects of Yolkin on Contact Sensitivity and Immune Phenotypes in Juvenile Mice
Molecules,
Год журнала:
2024,
Номер
29(14), С. 3254 - 3254
Опубликована: Июль 10, 2024
Yolkin,
an
egg
yolk
immunoregulatory
protein,
stimulates
the
humoral
but
inhibits
cellular
immune
response
in
adult
mice.
The
aim
of
this
investigation
was
to
evaluate
effects
yolkin
administration
on
using
a
model
juvenile,
i.e.,
28-day-
and
37-day-old,
We
examined
influence
magnitude
response,
which
determined
as
contact
sensitivity
(CS)
oxazolone
(OXA),
antibody
ovalbumin
(OVA).
Yolkin
administered
drinking
water,
followed
by
immunization
with
OXA
or
OVA.
In
parallel,
phenotypic
changes
lymphoid
organs
were
following
treatment
prior
immunization.
results
showed
that
had
stimulatory
effect
CS
mice
treated
from
37th
day
life
not
28th
life.
contrast,
no
regulatory
production
found
37-day-old
Phenotypic
studies
revealed
significant
content
B
cells
T
cell
subpopulations,
including
CD4+CD25+Foxp3
cells.
association
between
main
T-
B-cell
compartments,
well
importance
T-regulatory
CD8+
age
categories,
are
discussed.
conclude
generation
dependent
change
stimulation
juvenile
suppression
Язык: Английский