Nutrients,
Год журнала:
2024,
Номер
17(1), С. 78 - 78
Опубликована: Дек. 28, 2024
Flavonoids
are
naturally
occurring
polyphenolic
compounds
known
for
their
extensive
range
of
biological
activities.
This
review
focuses
on
the
inhibitory
effects
flavonoids
acetylcholinesterase
(AChE)
and
potential
as
therapeutic
agents
cognitive
dysfunction.
AChE,
a
serine
hydrolase
that
plays
crucial
role
in
cholinergic
neurotransmission,
is
key
target
treatment
impairments
due
to
its
function
acetylcholine
hydrolysis.
Natural
compounds,
particularly
flavonoids,
have
demonstrated
significant
inhibition
positioning
them
promising
alternatives
or
adjuncts
neuropharmacology.
study
specifically
examines
such
quercetin,
apigenin,
kaempferol,
naringenin,
investigating
efficacy,
binding
mechanisms,
additional
neuroprotective
properties,
including
antioxidant
anti-inflammatory
effects.
In
vitro,
vivo,
silico
analyses
reveal
these
effectively
interact
with
both
active
peripheral
anionic
sites
resulting
increased
levels
stabilization
signaling.
Their
mechanisms
action
extend
beyond
mere
enzymatic
inhibition,
they
also
exhibit
anti-amyloidogenic
thereby
offering
multifaceted
approach
neuroprotection.
Given
findings,
hold
considerable
modulators
implications
enhancing
treating
neurodegenerative
diseases.
Future
studies
should
prioritize
enhancement
flavonoid
bioavailability,
evaluate
efficacy
clinical
settings,
explore
synergistic
when
combined
established
therapies
fully
harness
neurotherapeutic
agents.
Biomedicines,
Год журнала:
2024,
Номер
12(6), С. 1353 - 1353
Опубликована: Июнь 18, 2024
Apigenin
is
a
powerful
flavone
compound
found
in
numerous
fruits
and
vegetables,
it
offers
health-promoting
benefits.
Many
studies
have
evidenced
that
this
has
potential
role
as
an
anti-inflammatory
antioxidant
compound,
making
promising
candidate
for
reducing
the
risk
of
pathogenesis.
It
also
been
to
positively
affect
various
systems
body,
such
respiratory,
digestive,
immune,
reproductive
systems.
effective
treating
liver,
lung,
heart,
kidney,
neurological
diseases,
diabetes,
maintaining
good
oral
skin
health.
Multiple
reported
capable
suppressing
types
cancer
through
induction
apoptosis
cell-cycle
arrest,
cell
migration
invasion,
reduction
inflammation,
inhibiting
angiogenesis.
When
used
combination
with
other
drugs,
apigenin
increases
their
efficacy,
reduces
side
effects,
improves
response
chemotherapy.
This
review
broadly
analyzes
apigenin’s
disease
management
by
modulating
biological
activities.
In
addition,
described
interaction
compounds
or
drugs
nanoformulation
different
pathogeneses.
Further
extensive
research
needed
explore
mechanism
action,
safety,
efficacy
prevention
treatment.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 23, 2025
Abstract
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
offer
the
advantages
of
precise
temporal
spatial
selectivity
in
cancer
treatment,
minimizing
damage
to
normal
cells
while
effectively
eliminating
tumor
cells.
However,
therapeutic
efficacy
phototherapy
is
always
hindered
by
challenges
such
as
hypoxia
heat
resistance.
Herein,
a
pH‐responsive
metal‐drug
nanocomplex
(denoted
PAFH)
comprising
hypericin
(HYP),
apigenin
(APG),
polyvinylpyrrolidone
(PVP),
Fe
3+
developed
enhance
PDT
PTT.
The
PAFH
exhibits
properties
under
808
nm
laser
irradiation,
which
can
disassociate
response
acidic
microenvironment
temperature
increase
induced
PTT,
thereby
eventually
triggering
on‐site
release
APG
HYP.
released
inhibits
synthesis
shock
protein
HSP‐90,
facilitating
PAFH‐mediated
PTT
kill
at
mild
temperature.
Additionally,
alleviates
then
regulates
expression
hypoxia‐inducible
factor
HIF‐1𝛼,
increasing
cellular
oxygen
levels
produce
singlet
for
enhanced
HYP‐mediated
inhibiting
metastasis.
Ultimately,
this
sophisticated
nanosystem
represents
an
advanced
strategy
promote
mitigating
counteracting
resistance,
significantly
improving
therapy.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Апрель 17, 2025
Abstract
Although
cancer
chemopreventive
agents
have
been
confirmed
to
effectively
protect
high-risk
populations
from
invasion
or
recurrence,
only
over
ten
drugs
approved
by
the
U.S.
Food
and
Drug
Administration.
Therefore,
screening
potent
is
crucial
reduce
constantly
increasing
incidence
mortality
rate
of
cancer.
Considering
lengthy
prevention
process,
an
ideal
agent
should
be
nontoxic,
inexpensive,
oral.
Natural
compounds
become
a
natural
treasure
reservoir
for
chemoprevention
because
their
superior
ease
availability,
cost-effectiveness,
safety.
The
benefits
as
in
various
studies.
In
light
this,
present
review
intended
fully
delineate
entire
scope
chemoprevention,
primarily
focuses
on
aspects
based
compounds,
specifically
focusing
mechanism
action
prevention,
discussing
detail
how
they
exert
effects
affecting
classical
signaling
pathways,
immune
checkpoints,
gut
microbiome.
We
also
introduce
novel
strategies
summarize
role
improving
chemotherapy
regimens.
Furthermore,
we
describe
discovering
anticancer
with
low
abundance
high
activity,
revealing
broad
prospects
drug
discovery
chemoprevention.
Moreover,
associate
precision
medicine,
discuss
challenges
encountered
Finally,
emphasize
transformative
potential
advancing
field
ability
more
effective
less
toxic
preventive
options
oncology.
Post-stroke
depression
is
a
common
complication
that
imposes
significant
burdens
and
challenges
on
patients.
The
occurrence
of
often
associated
with
frontal
lobe
hemorrhage,
however,
current
understanding
the
underlying
mechanisms
remains
limited.
Here,
pathogenic
circuitry
connectivity,
electrophysiological
alterations,
molecular
characteristics
are
investigated
related
to
in
adult
male
mice
following
unilateral
injection
blood
medial
prefrontal
cortex
(mPFC).
It
demonstrated
specific
neurological
hematoma
model
mPFC,
ventral
tegmental
area
(VTA)
shows
higher
percentage
connectivity
disruption
compared
lateral
habenula
(LHb)
striatum
(STR).
Additionally,
long-range
projections
originating
from
demonstrate
damage
percentages
within
connections
between
each
region
mPFC.
mPFC
neurons
reveal
reduced
neuronal
excitability
altered
synaptic
communication.
Furthermore,
transcriptomic
analysis
identifies
involvement
Janus
Kinase-Signal
Transducer
Activator
Transcription
(JAK-STAT)
signaling
pathway,
targeting
JAK-STAT
pathway
significantly
alleviates
severity
depressive
symptoms.
These
findings
improve
post-hemorrhagic
may
guide
development
efficient
treatments.
Food Reviews International,
Год журнала:
2024,
Номер
unknown, С. 1 - 29
Опубликована: Авг. 5, 2024
The
incidence
of
kidney
diseases
is
increasing
globally,
posing
a
serious
threat
to
human
health.
Studies
have
shown
that
apigenin,
natural
dietary
flavonoid
with
multiple
bioactivities,
may
be
effective
in
protecting
the
kidneys
and
treating
variety
diseases.
This
review
collates
discusses
available
evidence
on
therapeutic
effects
apigenin
common
In
addition,
specific
molecular
mechanisms
by
which
exerts
its
renoprotective
are
described,
informs
further
research
clinical
nutritional
applications
field
renal
