The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China

The Lancet Infectious Diseases, Год журнала: 2024, Номер 24(8), С. 845 - 855

Опубликована: Апрель 22, 2024

Growing evidence suggests that symptoms associated with post-COVID-19 condition (also known as long COVID) can affect multiple organs and systems in the human body, but their association viral persistence is not clear. The aim of this study was to investigate SARS-CoV-2 diverse tissues at three timepoints following recovery from mild COVID-19, well its COVID symptoms.

Язык: Английский

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Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches

Biomolecules, Год журнала: 2024, Номер 14(7), С. 835 - 835

Опубликована: Июль 11, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID’s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Язык: Английский

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The Effect of 14-Day Consumption of Hydrogen-Rich Water Alleviates Fatigue but Does Not Ameliorate Dyspnea in Long-COVID Patients: A Pilot, Single-Blind, and Randomized, Controlled Trial

Nutrients, Год журнала: 2024, Номер 16(10), С. 1529 - 1529

Опубликована: Май 19, 2024

(1) Background: Hydrogen (H2) may be a potential therapeutic agent for managing Long COVID symptoms due to its antioxidant and anti-inflammatory properties. However, more scientific literature is needed describe the effects of H2 administration on treating symptoms. A study aimed investigate impact hydrogen-rich water (HRW) fatigue dyspnea Long-COVID patients 14 consecutive days. (2) Methods: In this randomized, single-blind, placebo-controlled study, 55 participants were recruited, 23 them excluded. total 32 eligible randomized into group (n = 16) placebo (PW) in which they instructed consume or days, respectively. The completed Fatigue Severity Scale (FSS), Six-Minute Walk Test (6MWT), 30 s Chair Stand (30s-CST), Modified Medical Research Council Dyspnea Rating (mMRC), Pittsburgh Sleep Quality Index (PSQI), depression anxiety stress scale (DASS-21) before after intervention. linear mixed-effects model was used analyze HRW. Cohen’s d values assess effect size when significance observed. mean change with 95% confidence intervals (95% CI) also reported. (3) Results: HRW lowering FSS scores (p 0.046, [95% CI −20.607, −0.198, 0.696] improving distance 6WMT < 0.001, 41.972, 61.891], 1.010), time 30s-CST 0.002, 1.570, 6.314], 1.190), PSQI 0.012, −5.169, 0.742], 1.274) compared PW significantly moderate size, while there no significant difference mMRC score 0.556) DASS-21 > 0.143). (4) Conclusions: This demonstrates that might an effective strategy alleviating cardiorespiratory endurance, musculoskeletal function, sleep quality. Still, it does not ameliorate among patients.

Язык: Английский

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A blood supply pathophysiological microcirculatory mechanism for the Long COVID

Опубликована: Июль 30, 2024

Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID‑19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements basic laws. In this work, a common framework pathophysiological mechanism presented, based on blood supply deprivation and flow diffusion equation. Methods: Case-control studies with statistically significant differences between cases (post-COVID patients) controls, from multiple tissues geographical areas, were gathered tabulated. Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary (CDR), percentage perfused vessels (PPVR). Both ML hemodynamic decrease (HD), incorporated in tissue (SR) estimation. Results: data found 763 post-COVID patients an average VDR, FAZE, CDR, PPVR 16%, 31%, 14%, 21%, respectively. HD 72 37%. estimated SR 634 reached sizeable 47%. This large creates conditions lower mass rates, hypoxia, undernutrition, which at multi-tissue level, long time, can explain wide variety symptoms. Conclusions: Disruption peripheral contribution both here be principal cause leading

Язык: Английский

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Potential associations of selected polymorphic genetic variants with COVID-19 disease susceptibility and severity

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0316396 - e0316396

Опубликована: Янв. 3, 2025

In this study, we analyzed the potential associations of selected laboratory and anamnestic parameters, as well 12 genetic polymorphisms (SNPs), with clinical COVID-19 occurrence severity in 869 hospitalized patients. The SNPs by qPCR were based on population-wide (GWAS) data previously indicating association COVID-19, additional that have been shown to be important cellular processes also examined. We confirmed pre-existing diabetes found an unexpected between less severe disease loss smell taste. Regarding polymorphisms, a higher allele frequency LZTFL1 IFNAR2 minor variants significantly correlated greater susceptibility (hospitalization) severity, similar tendency was observed for RAVER1 MUC5B variants. Interestingly, ATP2B4 haplotype, protecting against malaria, increased susceptibility, while diabetic patients lower presence reduced-function ABCG2 transporter variant. Our current results, which should reinforced larger studies, indicate together may predictive value COVID-19.

Язык: Английский

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Association between Mexican vaccination schemes and the duration of long COVID syndrome symptoms

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 12, 2025

Язык: Английский

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Cardiovascular Symposium on Perspectives in Long COVID

Clinical and Applied Thrombosis/Hemostasis, Год журнала: 2025, Номер 31

Опубликована: Янв. 1, 2025

Significant progress has been made in treating Coronavirus disease (COVID) – an infectious caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An ominous turn pandemic is evolving public health crisis emanating from persistent SARS-CoV-2 infection and its associated long-term impact. Long COVID or post–COVID describes protean symptoms that persist at least 3 months after onset of illness last for individuals with a history confirmed infection. become concern. Millions infected are now facing chronic multi-organ failures, including neuropsychiatric, cardiovascular, pulmonary, kidney complications. In general, cause long unclear but factors such as prolonged activation immune responses, viral persistence triggering transcription dysregulation genes normal thrombotic may play role cardiovascular Although inflammatory biomarkers reported other disorders, it remains whether similar manifestations following COVID. Medications sulodexide directed glycocalyx coagulation have demonstrated benefits smaller studies. Here, we describe outcomes symposium on underlying mechanisms

Язык: Английский

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Genetic and Epigenetic Intersections in COVID-19-Associated Cardiovascular Disease: Emerging Insights and Future Directions

Biomedicines, Год журнала: 2025, Номер 13(2), С. 485 - 485

Опубликована: Фев. 16, 2025

The intersection of COVID-19 and cardiovascular disease (CVD) has emerged as a significant area research, particularly in understanding the impact antiplatelet therapies like ticagrelor clopidogrel. been associated with acute complications, including myocardial infarction, thrombosis, heart failure, exacerbated by virus's ability to trigger widespread inflammation endothelial dysfunction. MicroRNAs (miRNAs) play critical role regulating these processes modulating gene expressions involved platelet function, inflammation, vascular homeostasis. This study explores potential miRNAs such miR-223 miR-126 biomarkers for predicting resistance or responsiveness patients disease. Identifying miRNA signatures linked drug efficacy could optimize treatment strategies at high risk thrombotic events during infection. Moreover, miRNA-mediated pathways offers new insights into how SARS-CoV-2 exacerbates CVD, through mechanisms cytokine storms damage. findings this research lead personalized therapeutic approaches, improving patient outcomes reducing mortality COVID-19-associated events. With global implications, addresses urgent need effective management CVD context COVID-19, focusing on integration molecular enhance precision therapy.

Язык: Английский

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Long COVID as a multisystem problem and recent challenges

Likarska sprava, Год журнала: 2025, Номер 1

Опубликована: Март 31, 2025

Abstract. The aim of the review is to identify and summarize main theories Long COVID, pathogenesis clinical signs. Materials Methods. 110 articles from PubMed, Scopus, Google Scholar, as well WHO data statistics on prevalence COVID for period 2022-2025, which contain relevant information this syndrome, were processed. Special attention paid lesions nervous system psycho-emotional sphere. Conclusions. 1. More than 65 million people are affected by COVID. High susceptibility observed in women, unvaccinated people, patients with chronic diseases. 2. hypotheses development inflammation due a cytokine storm, immune response production antibodies against SARS-CoV-2 proteins, nucleoprotein N spike S, vascular dysfunction increased blood-brain barrier permeability. 3. pathogenetic mechanism post-COVID syndrome persistence virus, dysregulation system, mitochondrial dysfunction, prothrombotic autoantibodies, contributes hypercoagulability. Lesions associated impaired neurotransmission, inflammation, cerebral hypoxia, formation “string vessels,” leads cognitive impairment. 4. leading symptoms damage are: “brain fog,” confusion, prolonged headache, fatigue, autonomic disorders, orthostatic insufficiency, peripheral form neuropathies, myopathies, isolated cranial nerve (anosmia agevia). 5. Depression, anxiety post-traumatic stress disorder, circadian rhythm sleep disorders signs impact sphere psychiatric disorders.

Язык: Английский

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The role of inflammatory gene polymorphisms in severe COVID-19: a review

Virology Journal, Год журнала: 2024, Номер 21(1)

Опубликована: Дек. 20, 2024

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global healthcare systems and spurred extensive research efforts over past three years. One critical aspect of disease is intricate interplay between virus host immune response, particularly role inflammatory gene expression in severe COVID-19. While numerous previous studies have explored genetic polymorphisms COVID-19, specifically focusing on genes their associations with severity remains limited. This review explores relationship outcomes within key genes. By investigating impact variations responses, which include cytokine production downstream signalling pathways, we aim to provide a comprehensive overview how contribute variability presentation. Through an in-depth analysis existing literature, shed light potential therapeutic targets personalized approaches that may enhance our understanding pathogenesis treatment strategies.

Язык: Английский

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