A Blood Supply Pathophysiological Microcirculatory Mechanism for Long COVID

Life, Год журнала: 2024, Номер 14(9), С. 1076 - 1076

Опубликована: Авг. 28, 2024

Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID-19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements basic laws. In this work, a common framework pathophysiological mechanism presented, based on blood supply deprivation and flow diffusion equation. Methods: Case–control studies with statistically significant differences between cases (post-COVID patients) controls, from multiple tissues geographical areas, were gathered tabulated. Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary (CDR), percentage perfused (PPVR). Both ML hemodynamic decrease (HD) incorporated in tissue (SR) estimation. Results: data found 763 post-COVID patients an average VDR, FAZE, CDR, PPVR 16%, 31%, 14%, 21%, respectively. HD 72 37%. estimated SR 634 reached sizeable 47%. This large creates conditions lower mass rates, hypoxia, undernutrition, which at multi-tissue level, long time, can explain wide variety symptoms. Conclusions: Disruption peripheral contribution both here be principal cause leading

Язык: Английский

---

Potential associations of selected polymorphic genetic variants with COVID-19 disease susceptibility and severity

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 14, 2024

Abstract In this study, we analyzed the potential associations of selected laboratory and anamnestic parameters, as well 12 genetic polymorphisms (SNPs), with clinical COVID-19 occurrence severity in 869 hospitalized patients. The SNPs by qPCR were based on population-wide (GWAS) data previously indicating association COVID-19. We confirmed disease several parameters found an unexpected between less severe loss smell taste. most cases, SNP analysis supported earlier results hospitalization severity, while role some unrecognized has also been observed. A was indicated presence a reduced-function ABCG2 transporter variant disease, which observed diabetic Our current results, should be reinforced larger studies, indicate that together may have predictive value for

Язык: Английский

---

Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving Cognitive Impairment

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11040 - 11040

Опубликована: Окт. 14, 2024

The European olive tree, Olea europaea L., and its polyphenols hold great therapeutic potential to treat neuroinflammation cognitive impairment. This review examines the evidence for anti-inflammatory neuroprotective actions of their in treatment long COVID neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS). Key findings suggest that exhibit antioxidant, anti-inflammatory, neuroprotective, antiviral properties, making them promising candidates intervention, especially when formulated unique combinations. Recommendations future research directions include elucidating molecular pathways through mechanistic studies, exploring implications polyphenol supplementation, conducting clinical trials assess efficacy safety. Investigating synergistic effects with other agents addressing different targets is suggested further exploration. reviewed strengthens translational value conditions involving dysfunction emphasizes novelty new formulations.

Язык: Английский

---