International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 212 - 212
Опубликована: Дек. 30, 2024
Ischemia/reperfusion (IR) injury is a complex pathophysiological process in which the restoration of blood flow to ischemic tissue paradoxically exacerbates damage and death [...].
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4900 - 4900
Опубликована: Апрель 30, 2024
The high mortality rate among patients with acute myocardial infarction (AMI) is one of the main problems modern cardiology. It quite obvious that there an urgent need to create more effective drugs for treatment AMI than those currently used in clinic. Such could be enzyme-resistant peptide analogs glucagon-like peptide-1 (GLP-1). GLP-1 receptor (GLP1R) agonists can prevent ischemia/reperfusion (I/R) cardiac injury. In addition, chronic administration GLP1R alleviate development adverse remodeling infarction, hypertension, and diabetes mellitus. protect heart against oxidative stress reduce proinflammatory cytokine (IL-1β, TNF-α, IL-6, MCP-1) expression myocardium. stimulation inhibits apoptosis, necroptosis, pyroptosis, ferroptosis cardiomyocytes. activation augments autophagy mitophagy downregulate reactive species generation through Epac GLP1R/PI3K/Akt/survivin pathway. GLP1R, kinases (PKCε, PKA, Akt, AMPK, PI3K, ERK1/2, mTOR, GSK-3β, PKG, MEK1/2, MKK3), enzymes (HO-1 eNOS), transcription factors (STAT3, CREB, Nrf2, FoxO3), KATP channel opening, MPT pore closing are involved cardioprotective effect agonists.
Язык: Английский
Процитировано
11
Experimental Eye Research, Год журнала: 2025, Номер 253, С. 110299 - 110299
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116793 - 116793
Опубликована: Май 21, 2024
High-altitude myocardial injury (HAMI) represents a critical form of altitude illness for which effective drug therapies are generally lacking. Notoginsenoside R1, prominent constituent derived from Panax notoginseng, has demonstrated various cardioprotective properties in models ischemia/reperfusion injury, sepsis-induced cardiomyopathy, cardiac fibrosis, and injury. The potential utility notoginsenoside R1 the management HAMI warrants prompt investigation. Following successful construction model, series experimental analyses were conducted to assess effects at dosages 50 mg/Kg 100 mg/Kg. results indicated that exhibited protective against hypoxic by reducing levels CK, CK-MB, LDH, BNP, leading improved function decreased incidence arrhythmias. Furthermore, was found enhance Nrf2 nuclear translocation, subsequently regulating SLC7A11/GPX4/HO-1 pathway iron metabolism mitigate ferroptosis, thereby mitigating inflammation oxidative stress induced high-altitude conditions. In addition, application ML385 confirmed involvement translocation therapeutic approach HAMI. Collectively, advantageous impacts on have been linked suppression ferroptosis via signaling.
Язык: Английский
Процитировано
5
Pharmacological Research, Год журнала: 2024, Номер 209, С. 107466 - 107466
Опубликована: Окт. 15, 2024
Myocardial ischemia causes extensive damage, further exacerbated by reperfusion, a phenomenon called myocardial ischemia/reperfusion injury (MIRI). Nowadays, the pathological mechanisms of MIRI have received attention. Oxidative stress, multiple programmed cell deaths, inflammation and others are all essential contributing to MIRI. Mitochondria energy supply centers cells. Numerous studies found that abnormal mitochondrial function is an "culprit" MIRI, mitophagy mediated phosphatase tensin homolog (PTEN)-induced kinase 1 (PINK1)/Parkin signaling pathway integral part maintaining function. Therefore, exploring association between PINK1/Parkin pathway-mediated crucial. This review will mainly summarize crucial role in MIR-induced several various potential interventions affect mitophagy, thus ameliorating
Язык: Английский
Процитировано
4
Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)
Опубликована: Ноя. 13, 2024
Abstract Coronary artery disease has a high mortality rate and is striking public health concern, affecting substantial portion of the global population. On early onset myocardial ischemia, thrombolytic therapy coronary revascularization could promptly restore bloodstream nutrient supply to ischemic tissue, efficiently preserving less severely injured myocardium. However, abrupt re-establishment blood flow triggers significant discharge previously accumulated oxidative substances inflammatory cytokines, leading further harm referred as ischemia/reperfusion (I/R) injury. Diabetes significantly raises vulnerability heart I/R injury due disrupted glucose lipid processing, impaired insulin sensitivity metabolic signaling, increased responses. Numerous studies have indicated that adipokines are crucial in etiology pathogenesis obesity, diabetes, hyperlipidemia, hypertension, disease. Adipokines such adiponectin, adipsin, visfatin, chemerin, omentin, apelin, which possess protective properties against activity resistance, been shown confer protection conditions atherosclerosis, hypertrophy, injury, diabetic complications. other hand, leptin resistin, known for their pro-inflammatory characteristics, linked elevated cardiac deposition, fibrosis. Meteorin-like (metrnl) exhibits opposite effects various pathological conditions. data on I/R, especially still incomplete controversial. This review focuses recent research regarding categorization function muscle, identification different signaling pathways involved under conditions, aiming facilitate exploration therapeutic strategies diabetes.
Язык: Английский
Процитировано
4
Journal of Cardiothoracic Surgery, Год журнала: 2025, Номер 20(1)
Опубликована: Янв. 15, 2025
miRNA, circRNA, and lncRNA play crucial roles in the pathogenesis progression of myocardial ischemia-reperfusion injury (MI/RI). This study aims to provide valuable insights into lncRNA, MI/RI from a bibliometric standpoint, with goal fostering further advancements this area. The relevant literature field was retrieved Science Citation Index Expanded (SCI-E) database within Web Science. "Analyze Results" "Citation Report" functions WOS were utilized compile annual publication citation counts field. Microsoft Office Excel 2019 used organize visualize data. Furthermore, visualization analyses countries/regions, institutions, authors, keywords, references conducted using software CiteSpace. A total 858 publications included for analysis published across 297 journals, Molecular Medicine Reports contributing highest number publications. Researchers 45 countries participated studies field, those China most research hotspots primarily focus on three areas: role MI/RI, their potential as therapeutic targets, biomarkers. Among these, circular RNA, therapy target, inflammatory response, cardiomyocyte ferroptosis are likely emerge emerging trends overall development is rise. compilation area may researchers more assistance selecting directions, ultimately benefiting patients.
Язык: Английский
Процитировано
0
Pathology - Research and Practice, Год журнала: 2025, Номер unknown, С. 155949 - 155949
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Endocrinology, Год журнала: 2025, Номер 16
Опубликована: Апрель 25, 2025
Diabetic cardiomyopathy (DCM) is a common and fatal cardiac complication caused by diabetes, with its pathogenesis involving various forms of cell death mitochondrial dysfunction, particularly ferroptosis injury. Recent studies have indicated that damage play crucial roles in the onset progression DCM, though their precise regulatory mechanisms remain unclear. Of particular interest interaction between damage, as well synergistic effects, which are not fully understood. This review summarizes injury DCM explores molecular involved, an emphasis on interplay these two processes. Additionally, article offers overview targeted drugs shown to be effective cellular experiments, animal models, clinical trials, analyzing action potential side effects. The goal provide insights for future drug development applications. Moreover, challenges prospects multi-target combination therapies personalized medicine interventions practice offer strategic guidance comprehensive prevention management DCM.
Язык: Английский
Процитировано
0
Talanta, Год журнала: 2024, Номер 278, С. 126452 - 126452
Опубликована: Июнь 22, 2024
Язык: Английский
Процитировано
3
Reviews in Cardiovascular Medicine, Год журнала: 2024, Номер 25(10)
Опубликована: Окт. 9, 2024
Myocardial ischemia/reperfusion injury (MIRI) is a major cause of cardiac death particularly in patients with diabetes. When the coronary artery partially or completely blocked, restoration blood perfusion can normally be achieved within certain time due to development advanced techniques such as percutaneous intervention (PCI) and bypass grafting (CABG) surgery. However, tissue may aggravate progressively even after ischemic myocardium restored normal perfusion. MIRI often associated various forms cell death, including apoptosis, autophagy, programmed necrosis, pyroptosis, ferroptosis, among others. Ferroptosis known iron-dependent that distinct from other modes death. under constitutive control by glutathione peroxidase 4 (GPX4), reduction GPX4 result ferroptosis if iron homeostasis physiologically maintained. The essences are substantial accumulation lipid peroxidation trigger Under impaired antioxidant system, cellular reactive oxygen species (ROS) leads which consequently results ferroptosis. shares few common features several types interplays autophagy apoptosis cardiovascular diseases. More more recent studies have demonstrated plays an important role MIRI. addressed relative importance deaths. In this review, we summarized basic aspects advances regarding molecular pathogenesis evaluated its MIRI, propose levels function determinant myocardial susceptibility (IRI) general enhanced vulnerability specifically
Язык: Английский
Процитировано
2