Natural Antidiabetic Agents: Current Evidence and Development Pathways from Medicinal Plants to Clinical use
Natural Product Communications,
Год журнала:
2025,
Номер
20(3)
Опубликована: Март 1, 2025
Diabetes
mellitus
is
a
long-term
metabolic
condition
marked
by
chronically
high
levels
of
glucose
in
the
blood
due
to
insufficient
synthesis
insulin
or
impaired
function.
Throughout
history,
several
civilizations
have
used
traditional
medicinal
plants
treat
and
control
diabetes.
This
paper
offers
thorough
review,
date,
antidiabetic
natural
compounds
origin,
specifically
highlighting
their
reported
modes
mechanisms
action
therapeutic
possibilities,
with
view
fast-tracking
possibility
transition
pharmaceutical
products
for
human
use.
Phytochemicals
such
as
flavonoids,
alkaloids,
terpenoids,
glycosides
notable
effects.
They
been
shown
via
many
processes,
including
boosting
secretion,
improving
sensitivity,
blocking
absorption
\gastrointestinal-tract,
regulating
carbohydrate
metabolism.
Unlike
earlier
reviews,
this
current
one,
addition
chemistry
proposed
action,
also
x-rays
effectiveness
safety
these
chemicals
combining
evidences
from
laboratory
research,
animal
experiments,
clinical
trials.
Several
substances,
Demethoxycurcumin,
Trigonelline,
Ginsenosides,
progressed
trials,
while
others
like
Allicin
Polypeptide-p
at
bedside.
Bisdemethoxycurcumin,
Vicine,
Gymnemosides,
are
now
preclinical
trial
phase,
suggesting
that
research
still
ongoing
there
promise
future
application.
The
review
highlights
evolution
diabetes
management,
potential
improve
treatment.
It
suggests
incorporating
plant-derived
into
treatments,
reducing
dependence
on
drugs
adverse
Язык: Английский
Association of Serum Levels of Terpenes With Metabolic Syndrome and Its Components in Adults
Indoor Air,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Aim:
Environmental
exposure
constitutes
a
significant
determinant
in
the
pathogenesis
of
metabolic
syndrome
(MetS).
Nevertheless,
contribution
environmental
factors
to
MetS
remains
ambiguous.
The
present
study
was
aimed
at
investigating
correlation
between
serum
terpenes
and
risk
general
population.
Methods:
A
cross‐sectional
conducted
among
1266
individuals
from
2013–2014
National
Health
Nutrition
Examination
Survey
(NHANES).
Serum
were
analyzed
using
weighted
logistic
regression
model.
Weighted
quantile
sum
(WQS)
utilized
explore
relationship
mixture
MetS.
restricted
cubic
spline
(RCS)
method
employed
assess
dose–response
them.
All
data
analyses
“Survey”
package
R
software
(Version
4.3.2).
Results:
population,
with
an
average
age
46.82
±
0.46
years
body
mass
index
(BMI)
28.97
kg/m
2
,
consisted
48.15%
males
67.99%
Whites.
Among
participants,
35.78%
diagnosed
showed
that
tertiles
levels
α
‐pinene,
β
limonene
positively
correlated
OR
value
1.90
(1.14,
3.16),
2.02
(1.23,
3.31),
2.35
(1.33,
4.13)
elevated
triglycerides
(TGs)
2.36
(1.63,
3.43),
3.51
(2.30,
5.38),
3.96
(2.55,
6.15)
(all
p
trend
<
0.05).
WQS
indicated
positive
association
terpene
(OR
=
1.65,
95%
CI:
1.18–2.3),
increased
TG
2.69,
1.94–3.71),
reduced
high‐density
lipoprotein
cholesterol
(HDL‐C)
1.46,
1.03–2.07)
0.01).
RCS
analysis
further
supported
relationship.
Conclusion:
This
suggested
potential
adverse
effects
on
human
health,
emphasizing
importance
interventions
maintaining
health.
Язык: Английский
Pinus koraiensis essential oil enhances glucose uptake and proliferation in SH-SY5Y neuroblastoma cells
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 4, 2024
Abstract
Aromatherapy
using
essential
oils
(EOs)
is
well
known
for
its
beneficial
effects
on
mental
health
and
neuroprotection.
However,
the
significant
molecular
mechanisms
have
not
yet
been
identified.
Recent
studies
identified
a
decrease
in
glucose
uptake
as
common
feature
across
various
neurodegenerative
diseases
(NDDs),
leading
to
mitochondrial
dysfunction
excessive
autophagy.
This
suggests
that
may
serve
only
an
energy
source
but
also
therapeutic
target
NDDs.
Using
SH-SY5Y
neuroblast-like
cells
inhibitor
BAY-876,
we
demonstrated
depletion
promoted
To
discover
potential
therapeutics
modulate
metabolism,
obtained
EO
from
Pinus
koraiensis
Siebold
&
Zucc.
(PKSZ)
steam
distillation.
PKSZ-EO
upregulated
mRNA
expression
of
SLC2A2
,
SLC2A3
SLC2A4
increased
cells.
Furthermore,
protected
BAY-876-induced
dysfunction,
cytostasis,
autophagy,
inflammation.
gas
chromatography-mass
spectrometry,
confirmed
high
levels
α-pinene,
inducer
GLUT4
expression,
PKSZ-EO.
These
results
suggest
exerts
protective
effect
against
stress,
highlighting
agent
Язык: Английский