Harnessing two-dimensional magnetic Poly(deep eutectic solvents) for matrix solid-phase dispersion extraction of polyphenols from roselle: Promoting antiphotoaging strategy

Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 154019 - 154019

Опубликована: Июль 19, 2024

Язык: Английский

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Microbial Astaxanthin Synthesis by Komagataella phaffii through Metabolic and Fermentation Engineering

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Astaxanthin is a kind of carotenoid with strong antioxidant ability, which has shown broad applications in the areas healthcare, medicine, cosmetics, food additives, and aquaculture. With increasing demand for natural products, microbial production astaxanthin become new hot spot. In this study, synthesis pathway was first metabolically constructed Komagataella phaffii (K. phaffii)(Pichia pastoris). By exploring combination different promoters, producers were obtained. Then, key enzymes explored, enzyme assembly strategies an increase NADPH supply used to improve production. Furthermore, fermentation parameters including temperature, concentration carbon source, nitrogen sources, metal ions, BHT (2,6-di-tert-butyl-4-methylphenol), Tween-80 comprehensively investigated growth synthesis. Finally, reached 716.13 mg/L by fed-batch 5 L bioreactor, highest synthesized K. phaffii.

Язык: Английский

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The Potential of Natural Compounds in UV Protection Products

Molecules, Год журнала: 2024, Номер 29(22), С. 5409 - 5409

Опубликована: Ноя. 16, 2024

Overexposure to ultraviolet radiation mainly leads skin disorders (erythema, burns, immunosuppression), aging, and cancer as the most serious side effect. It has been widely accepted that using sunscreen products is an important way protect against harmful effects of UV rays. Although commercial sunscreens have constantly changed improved over time, there are emerging concerns about safety conventional, organic, filters due adverse on humans (such photoallergic dermatitis, contact sensitivity, endocrine-disrupting effects, etc.) well accumulation in environment aquatic organisms. This why natural compounds increasingly being investigated used cosmetic pharmaceutical sunscreens. Some these available, non-toxic, safer for use, considerable protective properties less effects. Plant-based such flavonoids can absorb UVA UVB rays possess antioxidant, anticarcinogenic, anti-inflammatory contribute photoprotection. Apart from flavonoids, other certain vegetable oils, carotenoids, stilbenes, ferulic acid also UV-absorbing properties. vitamins might be beneficial protection their antioxidant activity. Therefore, aim this research was gain insight into potential replace or reduce amount conventional filters, based recent research.

Язык: Английский

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The state of the art in anti-aging: plant-based phytochemicals for skin care

Immunity & Ageing, Год журнала: 2025, Номер 22(1)

Опубликована: Янв. 31, 2025

Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin's structural integrity. Carotenoids, vitamins, essential fatty acids, phenolic compounds work acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, elastase, which degrade structure, reducing levels of inflammatory markers (IL-6, IL-8, etc.) matrix metalloproteinases (MMP-1, MMP-2) linked to aging. Recent research highlights that plant-based phytochemicals can improve elasticity, reduce hyperpigmentation, prevent breakdown important proteins, support wound healing, making them valuable components for care treatments. This review explores multifaceted roles in maintaining improving health, highlighting their mechanisms action potential anti-aging innovations.

Язык: Английский

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Nutritional Support of Chronic Obstructive Pulmonary Disease

Nutrients, Год журнала: 2025, Номер 17(7), С. 1149 - 1149

Опубликована: Март 26, 2025

Background: COPD is a heterogenous disease of the respiratory tract caused by diverse genetic factors along with environmental and lifestyle-related effects such as industrial dust inhalation and, most frequently, cigarette smoking. These lead to airflow obstruction chronic symptoms. Additionally, increased risk infections exacerbates airway inflammation in patients. As consequence complex pathomechanisms difficulty treatment, among leading causes mortality both western countries developing world. Results: The management still challenge for clinicians; however, alternative interventions smoking cessation lifestyle changes from sedentary life moderate physical activity special attention diet may ameliorate patients' health. Here, we reviewed different dietary components supplements on conditions COPD. Conclusions: patients are continuously exposed heavy metals, which commonly present smoke polluted air. Meanwhile, they often experience significant nutrient deficiencies, affect detoxification these toxic metals. This turn can further disrupt nutritional balance interfering absorption, metabolism, utilization essential micronutrients. Therefore, awareness deliberate efforts should be made check levels micronutrients, ensuring adequate antioxidants, vitamin D, K2, magnesium, iron, particularly important reducing development limiting severity.

Язык: Английский

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Selective Removal of Chlorophyll and Isolation of Lutein from Plant Extracts Using Magnetic Solid Phase Extraction with Iron Oxide Nanoparticles

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3152 - 3152

Опубликована: Март 9, 2024

In recent years, there has been a growing interest in plant pigments as readily available nutraceuticals. Photosynthetic pigments, specifically chlorophylls and carotenoids, renowned for their non-toxic antioxidant properties, are increasingly finding applications beyond health-promoting attributes. Consequently, is an ongoing need cost-effective methods of isolation. This study employs co-precipitation method to synthesize magnetic iron oxide nanoparticles. Scanning electron microscopy (SEM) coupled with energy dispersive spectrometry (EDS) confirms that aqueous environment oxidizing conditions yield nanosized particle sizes ranging from 80 140 nm. X-ray photoelectron spectroscopy (XPS) spectra indicate the presence hydrous FeO(OH) on surface oxide. The Brunauer–Emmett–Teller (BET) area obtained nanomaterial was 151.4 m2 g−1, total pore volumes pores 0.25 cm3 g−1 STP. material, designated nanoparticles (IONPs), serves adsorbent solid phase extraction (MSPE) isolation photosynthetic (chlorophyll a, lutein) extracts higher green plants (Mentha piperita L., Urtica dioica L.). Sorption chlorophyll onto confirmed using UV–vis spectroscopy, Fourier transform infrared photoacoustic (FT-IR/PAS), high-performance liquid chromatography (HPLC). Selective sorption requires minimum 3 g IONPs per 12 mg acetone solvent, dependent storage time 48 h. Extended contact extract, i.e., 72 h, ensures elimination remaining components except lutein, spectral purity 98%, recovered over 90% efficiency. mechanism removal relies interaction pigment’s carbonyl (C=O) groups hydroxyl (–OH) groups. Based molecular dynamics (MD) simulations, it proven selective adsorption also influenced by more favorable dispersion interactions between comparison other solutes. An significantly promotes pigments; however, results complete loss selectivity.

Язык: Английский

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Insights on the Anti-Inflammatory and Anti-Melanogenic Effects of 2′-Hydroxy-2,6′-dimethoxychalcone in RAW 264.7 and B16F10 Cells

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(2), С. 85 - 85

Опубликована: Янв. 29, 2025

Chalcones are recognized for their diverse pharmacological properties, including anti-inflammatory and anti-melanogenic effects. However, studies on 2′-hydroxy-2-methoxychalcone derivatives remain limited. This study investigated the melanin synthesis-inhibitory effects of three derivatives: 2′-hydroxy-2,4-dimethoxychalcone (2,4-DMC), 2′-hydroxy-2,5′-dimethoxychalcone (2,5′-DMC), 2′-hydroxy-2,6′-dimethoxychalcone (2,6′-DMC). In lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, 2,6′-DMC demonstrated a superior inhibition nitric oxide (NO) production, pro-inflammatory cytokines, expression inducible synthase (iNOS) cyclooxygenase-2 (COX-2) compared to other derivatives. A mechanistic analysis revealed that modulates NF-κB MAPK signaling pathways attenuate inflammation. Additionally, exhibited significant α-melanocyte-stimulating hormone (α-MSH)-induced synthesis in B16F10 melanoma cells by downregulating tyrosinase, TRP-1, TRP-2, MITF expression. regulation was achieved through suppression Wnt/β-catenin, PI3K/AKT, MAPK, PKA/CREB pathways. Compared 2,4-DMC 2,5′-DMC, 2,6′-DMC’s structural configuration, characterized methoxy groups at 2- 6′-positions, contributed its enhanced molecular stability binding affinity, amplifying inhibitory primary skin irritation test confirmed minimal irritation, demonstrating safety dermal applications. These findings suggest holds promise as dual-function agent managing inflammatory conditions hyperpigmentation-related disorders.

Язык: Английский

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Nasturtium officinale Microshoot Culture Multiplied in PlantForm Bioreactor—Phytochemical Profiling and Biological Activity

Molecules, Год журнала: 2025, Номер 30(4), С. 936 - 936

Опубликована: Фев. 18, 2025

Nasturtium officinale R. Br. (watercress) is an endangered species with valuable pharmaceutical, cosmetic, and nutritional properties. The purpose of this work was to evaluate the phytochemical profile biological activity extracts from microshoot cultures grown in PlantForm bioreactors parent plant material. After 20 days cultivation, achieved best results both terms key active ingredient content activity. glucosinolates (GSL) by UHPLC-DAD-MS/MS method showed that dominant compounds were glucobrassicin (493.00 mg/100 g DW, 10 days) gluconasturtiin (268.04 days). highest total polyphenol (TPC) obtained after a 20-day growth period (2690 mg GAE/100 DW). Among polyphenols, vitro sinapinic acid (114.83 ferulic (87.78 antioxidant potential assessed ABTS DPPH assays observed for ethanol extracts. inhibiting hyperpigmentation (18.12%) anti-elastase (79.78%) aqueous extract N. cultures. inhibited bacteria, including Cutibacterium acnes (MIC = 0.625 mg/mL). Antioxidant tests chelating capacity iron ions Fe2+ face emulsion higher than control.

Язык: Английский

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Bioactive Substances and Skin Health: An Integrative Review from a Pharmacy and Nutrition Perspective

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 373 - 373

Опубликована: Март 6, 2025

The skin is one of the largest and most important organs our body. There are numerous factors that related to health, including lifestyle factors, nutrition, or care. Bioactive substances from plant marine extracts play a key role in health. aim this research was compile main evidence on bioactive substances. An integrative review performed, reporting findings according PRISMA (2020). Thirteen search equations were developed. After applications process screening selection articles, 95 references compiled. results compounds classified into food-derived components, nutraceuticals, symbiotics, active origin, extracts). several indicate use interesting for highlighting some dietary nutrients, obtained metabolites origin that, showing anti-inflammatory antimicrobial effects, improvement conditions principles cosmetics.

Язык: Английский

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In Vitro Studies of the Effect of Oil Emulsions from Transgenic Flax Varieties on the Treatment of Wound Healing and Care of Human Skin with the Tendency to Inflammation

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2544 - 2544

Опубликована: Март 12, 2025

Excessive amounts of free-oxygen radicals produced during inflammation induce oxidative stress and lead to cell damage, thus delaying the transition into proliferation in wound healing process. Oxidative on skin cells also plays an important role pathogenesis inflammatory diseases. The aim planned vitro studies was assess mechanisms regenerative action protection against three oil emulsions from transgenic (GMO) flax varieties M, B, MB a linseed emulsion traditional NIKE oil. Antioxidant gene-protective properties were identified for tested healthy model under stress. wound-healing potential these assessed proliferation, cycle, migration, apoptosis necrosis assays. conducted research presented that are safe human because they do not cancer and, at same time, migration processes normal cells. Additionally, their use increases ability eliminate damaged Transgenic oils provide effect increased antioxidant effect, resulting stress, which atopic dermatitis psoriasis. Linen B has best protective epidermis cancer, is probably due presence amount stigmasterol its composition along with appropriate content polyphenol compounds, as well oleic linoleic acids.

Язык: Английский

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