Obesity and metabolism,
Год журнала:
2024,
Номер
21(4), С. 389 - 404
Опубликована: Окт. 8, 2024
Currently,
879
million
adults
in
the
world
are
obese.
Obesity
and
type
2
diabetes
have
common
key
pathophysiological
mechanisms.
Weight
loss
is
an
integral
part
of
management.
Advances
study
pathogenesis
obesity
contribute
to
development
introduction
into
clinical
practice
innovative
technologies
combat
epidemic
mellitus.
New
drugs
take
effect
at
level
central
nervous
system,
gastrointestinal
tract,
adipose
tissue,
kidneys,
liver,
pancreas,
skeletal
muscles.
The
safety
gene
therapy
being
evaluated,
potential
special
methods
drug
delivery
target
tissues
studied.
Randomized
studies
show
that
effectiveness
a
number
new
pharmacological
weight
carbohydrate
metabolism
normalization
already
almost
comparable
bariatric
surgery.
This
review
summarizes
literature
on
prospects
for
treatment
based
developments
primarily
field
peptide
drugs,
monoclonal
antibodies,
RNA
therapy.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 18, 2024
AbstractObjectiveOxidative
stress
decreases
the
ability
of
β-cells
to
secrete
insulin
through
glucolipotoxicity
pancreatic
islets.
Flavonoids
modulate
and
amylin
secretion
mainly
antioxidant
activities.
Coumarins
isomers
flavonoids
have
direct
effects
on
cardiovascular
system,
not
linked
This
study
aimed
investigate
5,7-dimethoxycoumarin
(Citropten)
fractions
present
in
grapefruit
peel
secretions
normal
male
Wistar
rats.MethodsMethanol
extract
peels
was
fractionated
using
vacuum
assisted
liquid
chromatography
with
n-Hexane,
Ethyl
acetate
Methanol.
Gas
Chromatography
Mass
Spectrometry
analysis
reported
ethyl
fraction
highest
concentration
(85.66%)
5,7-dimethoxycoumarin.
Intraperitoneal
Glucose
Tolerance
Test
performed
5
sets
rats
receiving
intraperitoneally:
1)
negative
control,
1ml
sterile
water
2)
positive
0.2mg/kg
glimepiride,
3)
containing
10mg/kg,
20mg/kg
5,7-dimethoxycoumarin,
4)
methanol
5a)1ml
H2O2(0.6%,
6%)
plus
5b)1000mg/kg
Vitamin
C
5,7-dimethoxycoumarin.ResultsResults
showed
10mg/kg
had
comparable
plasma
glucose
control
indirect
effect
unlike
acting
glimepiride;
less
effective.
Both
5,7-
dimethoxycoumarin
induced
extrapancreatic
synthesis
secretion.Conclusion5,7-dimethoxycoumarin
will
find
special
applications
management
obesity,
diabetics
chronic
complications.
Since
overall
regulation
is
achieved
synergy,
attention
should
be
shifted
from
insulin-based
amylin-based
therapy.
There
need
focus
natural
compounds
that
stimulate
release.
Obesity and metabolism,
Год журнала:
2024,
Номер
21(4), С. 389 - 404
Опубликована: Окт. 8, 2024
Currently,
879
million
adults
in
the
world
are
obese.
Obesity
and
type
2
diabetes
have
common
key
pathophysiological
mechanisms.
Weight
loss
is
an
integral
part
of
management.
Advances
study
pathogenesis
obesity
contribute
to
development
introduction
into
clinical
practice
innovative
technologies
combat
epidemic
mellitus.
New
drugs
take
effect
at
level
central
nervous
system,
gastrointestinal
tract,
adipose
tissue,
kidneys,
liver,
pancreas,
skeletal
muscles.
The
safety
gene
therapy
being
evaluated,
potential
special
methods
drug
delivery
target
tissues
studied.
Randomized
studies
show
that
effectiveness
a
number
new
pharmacological
weight
carbohydrate
metabolism
normalization
already
almost
comparable
bariatric
surgery.
This
review
summarizes
literature
on
prospects
for
treatment
based
developments
primarily
field
peptide
drugs,
monoclonal
antibodies,
RNA
therapy.
