Haemostatic Gene Expression in Cancer-Related Immunothrombosis: Contribution for Venous Thromboembolism and Ovarian Tumour Behaviour

Cancers, Год журнала: 2024, Номер 16(13), С. 2356 - 2356

Опубликована: Июнь 27, 2024

Ovarian cancer (OC) is the deadliest gynaecological malignancy. Identifying new prognostic biomarkers an important research field. Haemostatic components together with leukocytes can drive progression while increasing susceptibility to venous thromboembolism (VTE) through immunothrombosis. Unravelling underlying complex interactions offers prospect of uncovering relevant OC biomarkers, predictors cancer-associated thrombosis (CAT), and even potential targets for therapy. Thus, this study evaluated expression F3, F5, F8, F13A1, TFPI1, THBD in peripheral blood cells (PBCs) 52 patients. Those VTE after tumour diagnosis had a worse overall survival (OS) compared their counterparts (mean OS 13.8 ± 4.1 months 47.9 5.7 months, respectively; log-rank test, p = 0.001). Low pre-chemotherapy F3 F8 levels were associated higher OC-related (χ2, < 0.05). Regardless thrombogenesis, patients low baseline shorter progression-free (PFS) than (adjusted hazard ratio (aHR) 2.54; 0.021). Among those who not under platelet anti-aggregation therapy, also (aHR 6.16; 0.006). Moving forward, efforts should focus on external validation larger cohorts.

Язык: Английский

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Advances in Dendritic Systems and Dendronized Nanoparticles: Paradigm Shifts in Cancer Targeted Therapy and Diagnostics

Molecular Pharmaceutics, Год журнала: 2024, Номер 22(1), С. 28 - 57

Опубликована: Дек. 21, 2024

Cancer has emerged as a global health crisis, claiming millions of lives annually. Dendrimers and dendronized nanoparticles, novel class nanoscale molecules with highly branched three-dimensional macromolecular structures, have gained significant attention in cancer treatment diagnosis due to their unique properties. These dendritic macromolecules offer precisely controlled branching architecture, enabling functionalization specific targeting enhance the selective delivery therapeutic agents tumor cells while minimizing systemic toxicity. Through surface modifications incorporation various components, dendrimers demonstrate remarkable adaptability nanocarriers for biomedical imaging theranostic applications. Surface strategies, including PEGylation ligand attachment (e.g., folic acid, RGD peptide, lactobionic acid), further biocompatibility facilitate targeted cell imaging. Leveraging improved target specificity, nanosystems heightened sensitivity precision diagnostics. Notably, encapsulation metal nanoparticles within dendrimers, such gold shown promise enhancing capabilities. Ongoing advancements nanotechnology are poised increase sophistication complexity dendrimer-based systems, highlighting potential drug platforms, growing number clinical trials on horizon. This review provides comprehensive overview future prospects therapy diagnosis, exploring ability biocompatibility, reduce toxicity, improve outcomes across malignancies.

Язык: Английский

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The Transformative Role of Nanoenzymes in the Diagnosis, Targeted Treatment, and Prognosis of Ovarian Cancer. A comprehensive review

Developmental medico-life-sciences, Год журнала: 2024, Номер 1(10), С. 4 - 22

Опубликована: Дек. 13, 2024

Ovarian cancer is one of the most aggressive and deadly gynaecological malignancies remains frequently diagnosed at advanced stages because its asymptomatic progression inherent limitations current diagnostic tests. Nanoenzymes (a class nanotechnology-based artificial enzymes) have great promise in addressing these challenges. greatly improve sensitivity specificity biosensors including optical electrochemical systems, with real-time high-precision detection key biomarkers such as CA-125, HE4, mesothelin. The high accuracy biosensors, fluorescence surface plasmon resonance (SPR) based technologies, for early-stage diagnosis, cost-effective, portable, ultra-low limits make them attractive alternatives. Nanoenzyme-based drug delivery systems like liposomes, polymeric micelles, Nanocapsules therapeutic outcomes by allowing targeted transport to tumor tissues, reducing systemic toxicity, overcoming resistance treatment. PEGylated liposomal doxorubicin (Doxil), a formulation, has been shown enhanced efficacy platinum-resistant ovarian cancer, reduced adverse effects. Further theranostic applications metallic nanoparticles gold iron oxide can be realized using therapy imaging. These advancements come their challenges, however, biological barriers, scalability before clinical translation. Interdisciplinary research, validation, creation regulatory frameworks safety are needed future progress. offer revolutionize diagnosis treatment potential facilitate early detection, precision, patient outcome while filling huge gaps approaches.

Язык: Английский

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Cytotoxic Activity of Curcumin- and Resveratrol-Loaded Core–Shell Systems in Resistant and Sensitive Human Ovarian Cancer Cells

International Journal of Molecular Sciences, Год журнала: 2024, Номер 26(1), С. 41 - 41

Опубликована: Дек. 24, 2024

Due to the high mortality rate of ovarian cancer, there is a need find novel strategies improve current treatment modalities. Natural compounds offer great potential in this field but also require careful design systems for their delivery cancer cells. Our study explored anticancer effects resveratrol (RSV)- and curcumin (CUR)-loaded core–shell nanoparticles human We evaluated vitro cytotoxicity various nanocarriers (CUR 1-3, RSV I-III) delivered MDAH-2774 SKOV-3 cells comparison free RVS CUR after 24 h 72 treatment. A two-way ANOVA was applied compare results MTT assay. Confocal laser scanning microscopy employed visualize cellular uptake mitochondrial localization. findings revealed that with not significant, loaded effectively decreased viability The cell line more sensitive than SKOV-3. enhanced by its colocalization mitochondria were demonstrated. Further research focused on detailed biological most effective 2 3) should be conducted provide insights. These highlight promising role CUR-loaded

Язык: Английский

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Clinical Trial Protocol for ROSELLA: a phase 3 study of relacorilant in combination with nab-paclitaxel versus nab-paclitaxel monotherapy in advanced platinum-resistant ovarian cancer

Journal of Gynecologic Oncology, Год журнала: 2024, Номер 35(4)

Опубликована: Янв. 1, 2024

Ovarian cancer has the highest mortality among gynecologic cancers, primarily because it typically is diagnosed at a late stage and of development chemoresistance in recurrent disease. Improving outcomes women with platinum-resistant ovarian substantial unmet need. Activation glucocorticoid receptor (GR) by cortisol been shown to suppress apoptotic pathways used cytotoxic agents, limiting their efficacy. Selective GR modulation may be able counteract cortisol's antiapoptotic effects, enhancing chemotherapy's A previous phase 2 study that adding intermittently dosed relacorilant, selective modulator, nab-paclitaxel improved outcomes, including progression-free survival (PFS) overall (OS), minimal added toxicity, cancer. The ROSELLA aims confirm expand on these findings larger population.

Язык: Английский

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