Aging of the eye: Lessons from cataracts and age-related macular degeneration
Ageing Research Reviews,
Год журнала:
2024,
Номер
99, С. 102407 - 102407
Опубликована: Июль 6, 2024
Aging
is
the
greatest
risk
factor
for
chronic
human
diseases,
including
many
eye
diseases.
Geroscience
aims
to
understand
effects
of
aging
process
on
these
genetic,
molecular,
and
cellular
mechanisms
that
underlie
increased
disease
over
lifetime.
Understanding
increases
general
knowledge
physiology
impacted
by
processes
at
various
biological
extremes.
Two
major
age-related
cataract
macular
degeneration
(AMD)
are
caused
dysfunction
lens
retina,
respectively.
Lens
transparency
light
refraction
mediated
fiber
cells
lacking
nuclei
other
organelles,
which
provides
a
unique
opportunity
study
single
hallmark,
i.e.,
loss
proteostasis,
within
an
environment
limited
metabolism.
In
AMD,
local
photoreceptors/retinal
pigmented
epithelium/Bruch's
membrane/choriocapillaris
complex
in
macula
leads
photoreceptors
eventually
central
vision,
driven
nearly
all
hallmarks
shares
features
with
Alzheimer's
disease,
Parkinson's
cardiovascular
diabetes.
The
can
function
as
model
studying
basic
and,
vice
versa,
well-defined
be
used
tools
disease.
Язык: Английский
Oxidative Stress and Cataract Formation: Evaluating the Efficacy of Antioxidant Therapies
Biomolecules,
Год журнала:
2024,
Номер
14(9), С. 1055 - 1055
Опубликована: Авг. 25, 2024
This
comprehensive
review
investigates
the
pivotal
role
of
reactive
oxygen
species
(ROS)
in
cataract
formation
and
evaluates
potential
antioxidant
therapies
mitigating
this
ocular
condition.
By
elucidating
mechanisms
oxidative
stress,
article
examines
how
ROS
contribute
to
deterioration
lens
proteins
lipids,
leading
characteristic
aggregation,
cross-linking,
light
scattering
observed
cataracts.
The
provides
a
thorough
assessment
various
strategies
aimed
at
preventing
managing
cataracts,
such
as
dietary
antioxidants
(i.e.,
vitamins
C
E,
lutein,
zeaxanthin),
well
pharmacological
agents
with
antioxidative
properties.
Furthermore,
explores
innovative
therapeutic
approaches,
including
gene
therapy
nanotechnology-based
delivery
systems,
designed
bolster
defenses
tissues.
Concluding
critical
analysis
current
research,
offers
evidence-based
recommendations
for
optimizing
therapies.
literature
on
use
prevent
is
sparse.
There
lack
conclusions;
further
clinical
studies
are
needed
endorse
patients
cataractogenesis.
However,
personalized
treatment
plans
considering
individual
patient
factors
disease
stages
can
be
applied.
serves
valuable
resource,
providing
insights
into
alleviate
burden
Язык: Английский
Oxidative Stress in Cataract Formation: Is There a Treatment Approach on the Horizon?
Antioxidants,
Год журнала:
2024,
Номер
13(10), С. 1249 - 1249
Опубликована: Окт. 16, 2024
Cataracts,
a
leading
cause
of
blindness
worldwide,
are
closely
linked
to
oxidative
stress-induced
damage
lens
epithelial
cells
(LECs).
Key
factors
contributing
cataract
formation
include
aging,
arterial
hypertension,
and
diabetes
mellitus.
Given
the
high
global
prevalence
cataracts,
burden
cataract-related
visual
impairment
is
substantial,
highlighting
need
for
pharmacological
strategies
supplement
surgical
interventions.
Understanding
molecular
pathways
involved
in
stress
during
development
may
offer
valuable
insights
designing
novel
therapeutic
approaches.
This
review
explores
role
formation,
focusing
on
critical
mechanisms,
such
as
mitochondrial
dysfunction,
endoplasmic
reticulum
stress,
loss
gap
junctions,
various
cell
death
LECs.
Additionally,
we
discuss
emerging
potential
targeting
options,
including
antioxidant-based
treatments.
Язык: Английский