Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1388 - 1388
Опубликована: Окт. 28, 2024
:
Hydrogels
produced
using
the
freeze-thaw
method
have
demonstrated
significant
potential
for
wound
management
applications.
However,
their
production
requires
precise
control
over
critical
factors
including
freezing
temperature
and
choice
of
matrix-forming
excipients,
which
no
consensus
on
optimal
conditions
currently
exists.
This
study
aimed
to
address
this
gap
by
evaluating
effects
above-mentioned
variables
cryogel
performance.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июль 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
Metal‐protein
hybrid
materials
represent
a
novel
class
of
functional
that
exhibit
exceptional
physicochemical
properties
and
tunable
structures,
rendering
them
remarkable
applications
in
diverse
fields,
including
engineering,
biocatalysis,
biosensing,
biomedicine.
The
design
development
multifunctional
biocompatible
metal‐protein
have
been
the
subject
extensive
research
key
aspiration
for
practical
clinical
settings.
This
review
provides
comprehensive
analysis
strategies,
intrinsic
properties,
biomedical
these
materials,
with
specific
emphasis
on
their
potential
cancer
therapy,
drug
vaccine
delivery,
antibacterial
treatments,
tissue
regeneration.
Through
rational
design,
stable
can
be
synthesized
using
straightforward
methods,
enabling
therapeutic,
immunomodulatory,
other
desired
functionalities.
Finally,
outlines
existing
limitations
challenges
associated
evaluates
translation,
providing
insights
into
implementation
within
applications.
There
is
ongoing
research
for
biomedical
applications
of
polyvinyl
alcohol
(PVA)-based
hydrogels;
however,
the
execution
this
has
not
yet
been
achieved
at
an
appropriate
level
commercialization.
Advanced
perception
necessary
design
and
synthesis
suitable
materials,
such
as
PVA-based
hydrogel
applications.
Among
polymers,
drawn
great
interest
in
owing
to
their
attractive
potential
with
characteristics
good
biocompatibility,
mechanical
strength,
apposite
water
content.
By
designing
approach
investigating
structure,
hydrogels
can
attain
superb
cytocompatibility,
flexibility,
antimicrobial
activities,
signifying
that
it
a
candidate
tissue
engineering
regenerative
medicine,
drug
delivery,
wound
dressing,
contact
lenses,
other
fields.
In
review,
we
highlight
current
progresses
on
explaining
diverse
usage
across
variety
areas.
We
explain
numerous
techniques
related
phenomena
based
these
materials.
This
review
may
stipulate
wide
reference
future
acumens
materials
extensive
Gels,
Год журнала:
2024,
Номер
10(9), С. 589 - 589
Опубликована: Сен. 13, 2024
Drug
delivery
to
the
ocular
system
is
affected
by
anatomical
factors
like
corneal
epithelium,
blinking
reflex,
aqueous
blood
barrier,
and
retinal
which
lead
quick
removal
from
site
inefficient
drug
delivery.
Developing
a
mechanism
that
targets
specific
eye
tissue
major
hurdle
for
researchers.
Our
study
examines
challenges
of
absorption
in
these
pathways.
Hydrogels
have
been
researched
as
suitable
method
overcome
some
obstacles.
These
are
developed
alone
or
conjunction
with
other
technologies,
such
nanoparticles.
Many
polymer
hydrogel
nanoparticle
systems
utilizing
both
natural
synthetic
polymers
created
investigated;
each
has
pros
cons.
The
complex
release
encapsulated
agents
nanoparticles
depends
on
three
key
factors:
matrix
swelling,
drug-matrix
chemical
interactions,
diffusion.
This
exists
regardless
type
polymer.
provides
an
overview
classification
hydrogels,
mechanisms,
role
controlled
pharmaceutical
applications.
Additionally,
it
highlights
integration
nanotechnology
disease
therapy,
focusing
different
types
nanoparticles,
including
nanosuspensions,
nanoemulsions,
Finally,
review
discusses
current
commercial
formulations
recent
advancements
non-invasive
techniques.
objective
present
comprehensive
possibilities
enhancing
medication
through
systems.
Molecules,
Год журнала:
2024,
Номер
29(12), С. 2853 - 2853
Опубликована: Июнь 15, 2024
Purpose
of
the
study:
creation
a
dextran
coating
on
cerium
oxide
crystals
using
different
ratios
and
to
synthesize
nanocomposites,
selection
best
nanocomposite
develop
nanodrug
that
accelerates
quality
wound
healing
with
new
type
antimicrobial
effect.
Materials
methods:
Nanocomposites
were
synthesized
nitrate
polysaccharide
(6000
Da)
at
four
initial
Ce(NO3)3x6H2O
(by
weight)—1:0.5
(Ce0.5D);
1:1
(Ce1D);
1:2
(Ce2D);
1:3
(Ce3D).
A
series
physicochemical
experiments
performed
characterize
created
nanocomposites:
UV-spectroscopy;
X-ray
phase
analysis;
transmission
electron
microscopy;
dynamic
light
scattering
IR-spectroscopy.
The
biomedical
effects
nanocomposites
studied
human
fibroblast
cell
culture
an
evaluation
their
effect
metabolic
proliferative
activity
cells
MTT
test
direct
counting.
Antimicrobial
was
by
mass
spectrometry
gas
chromatography–mass
against
E.
coli
after
24
h
48
co-incubation.
Results:
According
studies,
nanocrystals
less
than
5
nm
in
size
diffraction
peaks
characteristic
dioxide
identified
all
nanocomposites.
With
increasing
concentration,
particle
decreased,
smallest
nanoparticles
(<2
nm)
Ce2D
Ce3D
composites.
results
showed
high
level
safety
nanoceria,
while
absence
cytotoxicity
(100%
survival
rate)
established
for
C3D
sols.
At
nanoceria
concentration
10−2
M,
fibroblasts
statistically
significantly
enhanced
only
when
co-cultured
Ce2D,
but
decreased
Ce3D.
72
co-cultivation
nano
composites
increased
highest
registered
Ce3D;
from
group,
differences
As
result
microbiological
study,
(bacteriostatic
effect)
found
Ce0.5D
which
inhibited
multiplication
average
22–27%,
h,
suppressed
58–77%,
most
pronounced
Ce0.5D,
Ce1D,
Ce2D.
Conclusions:
necessary
physical
characteristics
nanoceria–dextran
provide
biological
determined.
10−3
stimulates
proliferation
metabolism
up
2.5
times
allows
reduction
rate
microorganism
three
times,
selected
subsequent
creation.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 17, 2025
Skin
repair
and
regeneration
are
crucial
processes
in
restoring
the
integrity
of
skin
after
injury,
with
significant
implications
for
medical
treatments
plastic
surgery.
Multiomics,
an
integrated
approach
combining
genomics,
transcriptomics,
proteomics,
metabolomics,
offers
unprecedented
insights
into
complex
molecular
cellular
mechanisms
involved
healing.
This
review
explores
transformative
role
multiomics
elucidating
regeneration.
While
genomic
studies
identify
genetic
basis
wound
healing,
transcriptomics
proteomics
uncover
dynamic
changes
gene
protein
expression,
metabolomics
provides
a
snapshot
metabolic
alterations
associated
Integrative
can
also
novel
biomarkers
therapeutic
targets
Despite
technical
biological
challenges,
future
research
holds
great
promise
advancing
personalized
medicine
improving
healing
strategies.
Through
interdisciplinary
collaboration,
has
potential
to
revolutionize
our
understanding
repair,
paving
way
innovative
surgery
beyond.
