Updated mechanisms of MASLD pathogenesis

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Апрель 22, 2024

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) has garnered considerable attention globally. Changing lifestyles, over-nutrition, and physical inactivity have promoted its development. MASLD is typically accompanied by obesity strongly linked to metabolic syndromes. Given that prevalence on the rise, there an urgent need elucidate pathogenesis. Hepatic lipid accumulation generally triggers lipotoxicity induces or progress steatohepatitis (MASH) mediating endoplasmic reticulum stress, oxidative organelle dysfunction, ferroptosis. Recently, significant been directed towards exploring role of gut microbial dysbiosis in development MASLD, offering a novel therapeutic target for MASLD. Considering are no recognized pharmacological therapies due diversity mechanisms involved difficulty associated with undertaking clinical trials, potential targets remain elusive. Thus, this article aimed summarize evaluate prominent roles lipotoxicity, ferroptosis, microbes underlying their effects. Furthermore, existing advances challenges treatment were outlined.

Язык: Английский

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Biomarkers for Health Functional Foods in Metabolic Dysfunction-Associated Steatotic Liver Disorder (MASLD) Prevention: An Integrative Analysis of Network Pharmacology, Gut Microbiota, and Multi-Omics

Nutrients, Год журнала: 2024, Номер 16(18), С. 3061 - 3061

Опубликована: Сен. 11, 2024

Metabolic dysfunction-associated steatotic liver disorder (MASLD) is increasingly prevalent globally, highlighting the need for preventive strategies and early interventions. This comprehensive review explores potential of health functional foods (HFFs) to maintain healthy function prevent MASLD through an integrative analysis network pharmacology, gut microbiota, multi-omics approaches. We first examined biomarkers associated with MASLD, emphasizing complex interplay genetic, environmental, lifestyle factors. then applied pharmacology identify food components beneficial effects on metabolic function, elucidating their action mechanisms. identifies evaluates halting or reversing development disease in stages, as well that can evaluate success failure such strategies. The crucial role microbiota its metabolites prevention homeostasis discussed. also cover state-of-the-art omics approaches, including transcriptomics, metabolomics, integrated analyses, research preventing MASLD. These advanced technologies provide deeper insights into physiological mechanisms HFF development. concludes by proposing approach developing HFFs targeting prevention, considering Korean regulatory framework. outline future directions bridge gap between basic science practical applications narrative provides a foundation researchers industry professionals interested support health. Emphasis placed maintaining balance focusing early-stage intervention

Язык: Английский

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Research Progress on the Mechanism of Intestinal <i>Prevotella</i> Affecting the Occurrence and Development of Asthma

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(03), С. 1050 - 1057

Опубликована: Янв. 1, 2025

Язык: Английский

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Gut microbiota differences, metabolite changes, and disease intervention during metabolic - dysfunction - related fatty liver progression

World Journal of Hepatology, Год журнала: 2025, Номер 17(3)

Опубликована: Март 25, 2025

In the current era, metabolic dysfunction-associated steatotic liver disease (MASLD) has gradually developed into a major type of chronic that is widespread globally. Numerous studies have shown gut microbiota plays crucial and indispensable role in progression MASLD. Currently, become one important entry points for research this disease. Therefore, aim review to elaborate on further associations between MASLD, including changes differences healthy diseased liver. Meanwhile, considering fatty steatohepatitis are abnormal pathological states development exhibits different degrees fibrosis (such as mild severe fibrosis) during progression, we also conduct comparison these use them markers progression. It reveals production action mechanisms short-chain acids bile brought about by microbiota, impact lipopolysaccharide from Gram-negative bacteria addition, regulation inhibition related factors probiotics (including new-generation probiotics) will be explored, which help monitor patients with compositions future carry out personalized targeted therapies microbiota. This achieve progress preventing combating

Язык: Английский

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Clinical Study of Intelligent Tongue Diagnosis and Oral Microbiome for Classifying TCM Syndromes in MASLD

Опубликована: Апрель 23, 2025

Background This study aimed to analyze the tongue image features and oral microbial markers in different TCM syndromes related metabolic dysfunction-associated steatotic liver disease (MASLD). Methods involved 34 healthy volunteers 66 MASLD patients [36 with Dampness-Heat (DH) 30 Qi-Deficiency (QD) syndrome]. Oral microbiome analysis was conducted through 16S rRNA sequencing. Tongue feature extraction used Uncertainty Augmented Context Attention Network (UACANet), while syndrome classification performed using five machine learning methods based on microbiota. Results Significant differences color, coating, microbiota were noted between DH band QD patients. exhibited a red-crimson color greasy coating enriched Streptococcus Rothia tongue. In contrast, displayed pale higher abundances of Neisseria, Fusobacterium, Porphyromonas Haemophilus. Combining characteristics differentiated an AUC 0.939 accuracy 85%. Conclusion suggests that are metabolism, possess distinct biomarkers, supporting classification.

Язык: Английский

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Non-Alcoholic Fatty Liver Disease, Awareness of a Diagnostic Challenge—A Clinician’s Perspective

Gastroenterology Insights, Год журнала: 2024, Номер 15(4), С. 1028 - 1053

Опубликована: Дек. 5, 2024

Non-alcoholic fatty liver disease (NAFLD) is the main cause of chronic globally. NAFLD a complex pathology, considered to be hepatic expression metabolic syndrome (MetS). It supposed become indication for transplantation in coming years and estimated affect 57.5–74.0% obese people, 22.5% children 52.8% children, with 50% individuals type 2 diabetes being diagnosed NAFLD. Recent research has proved that an increase adipose tissue insulin resistance index important marker injury patients Despite underlying incidental damage growing worldwide health problem, mostly under-appreciated. Currently, multifactorial disease, various factors contributing its pathogenesis, associated mellitus, but also cardiovascular, kidney endocrine disorders (polycystic ovary syndrome, hypothyroidism, growth hormone deficiency). Hepatitis B hepatitis C, sleep apnea, inflammatory bowel diseases, cystic fibrosis, viral infections, autoimmune diseases malnutrition are some other conditions which can found. The aim this review emphasize that, from clinician’s perspective, actual valuable key diagnosis factor multiple conditions; thus, efforts need made order recognition consequences. Although there no global consensus, physicians should consider screening people who at risk A large dissemination current concepts on extensive collaboration between physicians, such as gastroenterologists, internists, cardiologists, diabetologists, nutritionists endocrinologists, equally needed ensure we have knowledge resources address public challenge.

Язык: Английский

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Dietary Quality, Perceived Health, and Psychological Status as Key Risk Factors for Newly-Developed Metabolic Dysfunction-Associated Steatotic Liver Disease in a Longitudinal Study

Nutrition, Год журнала: 2024, Номер 130, С. 112604 - 112604

Опубликована: Окт. 18, 2024

Язык: Английский

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The Association Between Prevotella copri and Advanced Fibrosis in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 24, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD), driven by obesity and metabolic syndrome, is increasingly prevalent a significant contributor to fibrosis, cirrhosis, liver-related mortality. Emerging research implicates the gut microbiome as critical player in MASLD progression, yet specific microbial drivers remain poorly understood. Here, we explore role of Prevotella copri (P. copri) progression through both human patient cohorts mouse model diet-induced obesity. Using 16S rRNA sequencing, identified elevated P. abundance patients with advanced linked shifts diversity bacterial network connectivity. To investigate causality, experimental colonization mice on high-fat diet worsened copri-colonized showing increases hepatic steatosis, triglyceride accumulation, body weight, independent caloric intake. At molecular level, downregulated key lipid metabolism genes, such Carnitine Palmitoyltransferase 1, Diacylglycerol Acyltransferase, Adipose Triglyceride Lipase, impaired tight intestinal junction integrity downregulation cluadins, occludin, zonula occludens-1. Collectively, our findings position possible driver promoting steatosis accumulation fibrosis decreased integrity. These insights suggest promising therapeutic avenue target signatures like curb mitigate associated risk fibrosis.

Язык: Английский

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The microbiome’s influence on obesity: mechanisms and therapeutic potential

Science China Life Sciences, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Язык: Английский

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An Integrated Analysis of the Role of Gut Microbiome-Associated Metabolites in the Detection of MASH-Related Cirrhosis

Metabolites, Год журнала: 2024, Номер 14(12), С. 681 - 681

Опубликована: Дек. 4, 2024

Background and aim: The prevalence adverse outcomes of metabolic dysfunction associated with steatotic liver disease (MAFLD) are increasing. changes in the gut microbiota metabolites dysfunction-associated steatohepatitis (MASH) regarded as an essential part progression MAFLD. This study aimed to identify involved development MAFLD patients. Method: enrolled 90 patients (healthy controls, HC: n = 30; MASH: MASH-related cirrhosis, MC: 30), their fecal samples were collected for 16S rRNA sequencing non-targeted LC–MS/MS metabolomics analysis. Data preprocessing statistical analyses performed using QIIME2 software, Pynast, package, Progenesis QI, R program. Results: abundance Prevotellaceae at family level Prevotella genus was lower MASH NC than HC samples. Both showed strongest correlation via random forest Untargeted used quantitatively screen discrepant stool from three groups. Linolenic acid (LA)-related metabolite levels significantly Associations between Prevotella- or LA-related function discovered. A high MASH. Conclusion: identified that dysfunction. LA depleted during progression, additional supplementation may be a potential strategy future treatment

Язык: Английский

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