Antioxidants, Год журнала: 2024, Номер 13(11), С. 1376 - 1376
Опубликована: Ноя. 11, 2024
L., commonly known as cocoa, has been an integral part of human culture and diet for thousands years. However, recent scientific research highlighted its potential therapeutic properties, particularly in the treatment cancer inflammatory diseases. This comprehensive review analyzes anti-inflammatory anticancer effects
Язык: Английский
Molecular Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Май 25, 2025
Zein nanoparticles (ZNPs) have gained significant attention as biocompatible and biodegradable nanocarrier systems for brain-targeted drug delivery. Their ability to encapsulate hydrophobic drugs undergo surface modifications enables effective blood-brain barrier (BBB) penetration through receptor-mediated transcytosis. Functionalization approaches, such PEGylation ligand conjugation, been explored enhance BBB transport improve bioavailability. Additionally, ZNPs hold the potential theranostic applications, integrating delivery with real-time diagnostics facilitate personalized treatment strategies. This review provides a comprehensive evaluation of ZNPs, discussing their fabrication techniques, modifications, mechanisms across BBB. A comparative analysis other (liposomes, polymeric NPs, dendrimers, lipid-based carbon nanotubes) highlights superior biodegradability, lower toxicity, clinical translation. Furthermore, we explore latest advancements in ZNP-based neurological disorders, including glioblastoma, Parkinson's, Alzheimer's. Despite advantages, translation remains challenging due scalability issues, batch-to-batch variability, regulatory constraints. Future research should optimize functionalization strategies, release kinetics, conduct long-term safety evaluations. With continued nanotechnology pharmaceutical engineering, represent promising, sustainable platform improving therapeutic interventions.
Язык: Английский
Процитировано
0
ACS Omega, Год журнала: 2025, Номер unknown
Опубликована: Май 30, 2025
Язык: Английский
Процитировано
0
Medicina, Год журнала: 2024, Номер 60(9), С. 1384 - 1384
Опубликована: Авг. 24, 2024
Nanomedicine is a newer, promising approach to promote neuroprotection, neuroregeneration, and modulation of the blood–brain barrier. This review includes integration various nanomaterials in neurological disorders. In addition, gelatin-based hydrogels, which have huge potential due biocompatibility, maintenance porosity, enhanced neural process outgrowth, are reviewed. Chemical modification these especially with guanidine moieties, has shown improved neuron viability underscores tailored biomaterial design applications. further discusses strategies modulate barrier—a factor critically associated effective delivery drugs central nervous system. These advances bring supportive solutions solving conditions innovative therapies for their treatment. Nanomedicine, as applied neuroscience, presents significant leap forward new therapeutic that might help raise treatment management disorders much better levels. Our aim was summarize current state-of-knowledge this field.
Язык: Английский
Процитировано
3
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 11357 - 11378
Опубликована: Ноя. 1, 2024
Abstract: Nanoparticle-based drug delivery presents a promising solution in enhancing therapies for neurological diseases, particularly cognitive impairment. These nanoparticles address challenges related to the physicochemical profiles of drugs that hinder their central nervous system (CNS). Benefits include improved solubility due particle size reduction, enhanced penetration across blood-brain barrier (BBB), and sustained release mechanisms suitable long-term therapy. Successful application nanoparticle systems requires careful consideration characteristics tailored CNS delivery, encompassing distribution, surface charge morphology, loading capacity, kinetics. Literature review reveals three main types developed function enhancement: polymeric nanoparticles, lipid-based metallic or inorganic nanoparticles. Each type its production methods possess distinct advantages limitations. Further modifications such as coating agents ligand conjugation have been explored enhance brain cell uptake. Evidence supporting development shows efficacy outcomes, evidenced by assessments, modulation pro-oxidant markers, anti-inflammatory activities. Despite these advancements, clinical trials validating treating defects are lacking. Therefore, findings underscore need researchers expedite testing provide robust evidence potential nanoparticle-based systems. Keywords: Nanoparticle, impairment, nanoparticle,
Язык: Английский
Процитировано
3
Antioxidants, Год журнала: 2024, Номер 13(11), С. 1376 - 1376
Опубликована: Ноя. 11, 2024
L., commonly known as cocoa, has been an integral part of human culture and diet for thousands years. However, recent scientific research highlighted its potential therapeutic properties, particularly in the treatment cancer inflammatory diseases. This comprehensive review analyzes anti-inflammatory anticancer effects
Язык: Английский
Процитировано
3