The Intricate Relationship Between Circadian Rhythms and Gastrointestinal Peptides in Obesity
Peptides,
Год журнала:
2025,
Номер
unknown, С. 171356 - 171356
Опубликована: Фев. 1, 2025
Язык: Английский
Targeting CB2 receptor with a novel antagonist reverses cognitive decline, neurodegeneration and pyroptosis in a TAU-dependent frontotemporal dementia mouse model
Brain Behavior and Immunity,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s Disease
Molecules,
Год журнала:
2025,
Номер
30(8), С. 1672 - 1672
Опубликована: Апрель 8, 2025
Parkinson’s
disease
(PD)
is
a
complex
neurodegenerative
disorder
with
debilitating
non-motor
symptoms,
including
gastrointestinal
dysfunction,
cardiovascular
abnormalities,
mood
and
anxiety
disorders,
cognitive
decline,
sleep
disturbances,
respiratory
pain.
Despite
their
significant
impact
on
quality
of
life,
these
symptoms
are
often
inadequately
addressed.
Propolis
natural
bee-derived
product,
rich
in
bioactive
compounds
anti-inflammatory,
antioxidant,
immunomodulatory,
neuroprotective
properties,
which
holds
potential
PD
due
to
its
multitarget
multipathway
actions,
addressing
various
underlying
mechanisms
symptom
diseases.
Preclinical
clinical
studies
suggest
that
propolis
may
influence
key
pathological
PD’s
symptoms.
Evidence
points
benefits
improving
cognition,
health,
alleviating
sleep-related
issues.
Although
research
remains
scarce,
findings
from
related
conditions
ability
associated
This
review
underscores
the
underexplored
therapeutic
PD,
drawing
existing
evidence
advocating
for
further
fully
assess
role
patient
outcomes.
Язык: Английский
The Gut Microbiome-Neuroglia Axis: Implications for Brain Health, Inflammation, and Disease
Neuroglia,
Год журнала:
2024,
Номер
5(3), С. 254 - 273
Опубликована: Авг. 1, 2024
The
human
central
nervous
system
is
convolutedly
connected
to
the
gut
microbiome,
a
diverse
community
of
microorganisms
residing
in
gastrointestinal
tract.
Recent
research
has
highlighted
bidirectional
communication
between
microbiome
and
neuroglial
cells,
which
include
astrocytes,
microglia,
oligodendrocytes,
ependymal
cells.
These
cells
are
essential
for
maintaining
CNS
homeostasis,
supporting
neuronal
function,
responding
pathological
conditions.
This
review
examines
interactions
neuroglia,
emphasizing
their
critical
roles
brain
health
development
neurological
disorders.
Dysbiosis,
or
imbalance
been
associated
with
various
psychiatric
conditions,
such
as
autism
spectrum
disorder,
anxiety,
depression,
neurodegenerative
diseases
like
Alzheimer’s
Parkinson’s.
influences
function
through
microbial
metabolites,
immune
modulation,
neuroinflammatory
responses.
Understanding
these
paves
way
new
therapeutic
targets
strategies
preventing
treating
scoping
aims
highlight
mechanisms
microbiome-neuroglia
axis
its
potential
target.
Язык: Английский
Sleep deprivation-induced shifts in gut microbiota: Implications for neurological disorders
Neuroscience,
Год журнала:
2024,
Номер
565, С. 99 - 116
Опубликована: Ноя. 30, 2024
Язык: Английский
WuYou Decoction effectively reduces neuronal damage, synaptic dysfunction, and Aβ production in rats exposed to chronic sleep deprivation by modulating the Aβ-related enzymes and SIRT1/Nrf2/NF-κB pathway
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
unknown, С. 118939 - 118939
Опубликована: Окт. 1, 2024
Язык: Английский