Bibliometric analysis of extracellular vesicles in osteoarthritis DOI Creative Commons
Ga Liao, Huixu Xie, Lin Kang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 30, 2024

Abstract Osteoarthritis (OA) is a common degenerative joint disease with complex risk factors and an unclear pathogenesis. The onset insidious, mild early symptoms, the progression irreversible. Current treatment options cannot completely cure disease. Therefore, development of novel therapeutic approaches prevention strategies crucial for alleviating burden enhancing quality life patients OA. Extracellular vesicles (EVs) naturally possess biocompatibility low immunogenicity, showing significant potential in drug delivery cell-free therapy. To comprehensively understand research status application prospects EVs OA, this review employs bibliometric methods to explore collaboration patterns within field, current statuses, emerging directions. Additionally, it thoroughly reviews mechanisms integration engineering technologies biomaterials enhance their efficacy OA treatment. goal provide scientific evidence references therapies clinical EVs.

Язык: Английский

The interplay between osteoarthritis and osteoporosis: Mechanisms, implications, and treatment considerations – A narrative review DOI Creative Commons
Kai Huang,

Haili Cai

Experimental Gerontology, Год журнала: 2024, Номер 197, С. 112614 - 112614

Опубликована: Окт. 23, 2024

Язык: Английский

Процитировано

4
Dissolving microneedles: A transdermal drug delivery system for the treatment of rheumatoid arthritis DOI

X. Wang,

Jiang Yue, Sun‐Wei Guo

и другие.

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125206 - 125206

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Clinical efficacy of probiotic supplementation in the treatment of knee osteoarthritis: a meta-analysis DOI Creative Commons

Miao Tian,

Youyang Zhu,

Shiyu Lu

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 9, 2025

We aimed to systematically evaluate and analyze the clinical efficacy of oral probiotics in treatment knee osteoarthritis (KOA) based on theory "gut-joint axis." searched PubMed, The Cochrane Library, Embase, China Knowledge Network (CNKI), Wanfang Database, Wipro Database (CQVIP) databases for randomized controlled trials KOA. literature was organized by Note express software, quality included evaluated according systematic evaluation method, meta-analysis performed using RevMan 5.4 software. Five with 694 participants were this study, results showed that observation group experienced significant reductions Western Ontario McMaster Universities Osteoarthritis Index total score, visual analog high-sensitivity C-reactive protein level compared control group, but did not show differences improvement stiffness regulation body weight. Oral had an ameliorative effect function, pain, inflammatory response patients KOA, our need be validated future large-scale studies. website is https://www.crd.york.ac.uk/PROSPERO/.

Язык: Английский

Процитировано

0
The Role of Methyl Canthin-6-one-2-carboxylate in Targeting the NLRP3 Inflammasome in Rheumatoid Arthritis Treatment DOI Creative Commons

Chung‐Che Tsai,

Tin-Yi Chu,

Po-Chih Hsu

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(4), С. 254 - 254

Опубликована: Апрель 7, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent synovial inflammation, joint destruction, and systemic complications. The nucleotide-binding domain, leucine-rich repeat family, pyrin domain-containing-3 (NLRP3) inflammasome plays pivotal role in RA pathogenesis driving the release of pro-inflammatory cytokines exacerbating oxidative stress. Recent studies identified methyl canthin-6-one-2-carboxylate (Cant) as potential therapeutic agent that modulates NLRP3 pathway. This review explores mechanistic Cant treatment, particularly its effect on stress, macrophages, inflammatory signaling pathways. Additionally, we discuss alternative complementary approaches, such gut microbiota modulation mesenchymal stem cell-based therapies, management RA. Although preliminary findings suggest exhibits promising anti-inflammatory effects, further preclinical clinical are necessary to validate efficacy. Future research should focus optimizing dosage, exploring combination elucidating broader implications targeting for treatment.

Язык: Английский

Процитировано

0
Exploring the Role of the Microbiome in Rheumatoid Arthritis—A Critical Review DOI Creative Commons

Plamena Ermencheva,

Georgi Kotov, Russka Shumnalieva

и другие.

Microorganisms, Год журнала: 2024, Номер 12(7), С. 1387 - 1387

Опубликована: Июль 9, 2024

Rheumatoid arthritis (RA) is a chronic, autoimmune rheumatic disease characterized by synovial joint inflammation with subsequent destruction as well systemic manifestation, leading to impaired mobility and quality of life. The etiopathogenesis RA still unknown, genetic, epigenetic environmental factors (incl. tobacco smoking) contributing susceptibility. link between genetic like "shared epitope alleles" the development known. However, why only some carriers have break in self-tolerance develop autoimmunity needs be clarified. presence autoantibodies patients' serum months years prior onset clinical manifestations has moved focus possible factors, including triggers that could contribute initiation perpetuation inflammatory reaction RA. Over past several years, role microorganisms at mucosal sites (i.e., microbiome) emerged an essential mediator An increasing number studies revealed microbial immunopathogenesis diseases. Interaction host immune system microbiota initiates loss immunological tolerance autoimmunity. alteration microbiome composition, so-called dysbiosis, associated Immune dysfunction caused dysbiosis sustains chronic inflammation. This review aims provide critical summary literature findings related hypothesis reciprocal relation system. Available data from reveal pivotal pathogenesis.

Язык: Английский

Процитировано

2
The causal relationship between the human gut microbiota and pyogenic arthritis: a Mendelian randomization study DOI Creative Commons

Boliang Bai,

Longfei Luo,

Feng Yao

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Ноя. 26, 2024

Recent studies have indicated the role of gut microbiota in progression osteoarticular diseases, however, causal relationship between and pyogenic arthritis remains unclear. There is also a lack theoretical basis for application treatment arthritis.

Язык: Английский

Процитировано

1
The signature of the gut microbiota associated with psoriatic arthritis revealed by metagenomics DOI Creative Commons
Wei Liu, Chunyan Li, Wenhui Xie

и другие.

Therapeutic Advances in Musculoskeletal Disease, Год журнала: 2024, Номер 16

Опубликована: Янв. 1, 2024

Gut microbiota is involved in the development of psoriatic arthritis (PsA), but until now, there has been a lack understanding PsA host-bacteria interaction.

Язык: Английский

Процитировано

0
Microbiome and Femoral Cartilage Thickness in Knee Osteoarthritis: Is There a Link? DOI
Noha Abdelhalim Elsawy, Aya Hanafy Ibrahiem,

Gihan Younis

и другие.

Cartilage, Год журнала: 2024, Номер unknown

Опубликована: Сен. 5, 2024

To assess the relation between microbiome and lipopolysaccharide (LPS), in blood synovial fluid (SF) with femoral cartilage thickness (FCT) measured by ultrasound (US) knee osteoarthritis (KOA) patients.

Язык: Английский

Процитировано

0
Evidence of Silencing of Intestinal Inflammatory and Immune Transcripts Following Induction of Joint Inflammation DOI Open Access
Meghan M. Moran, Jun Li, Quan Shen

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 17, 2024

ABSTRACT Disrupted intestinal epithelial barrier function has been proposed to be integral rheumatoid arthritis (RA) progression and pathogenesis. To further define the molecular pathways in synovial inflammation response of tissues, we have used a rat model mono-joint inflammatory arthritis, induced by intra-articular injection Complete Freund’s adjuvant (CFA). The predominant single into knee joint resulted rapid reproducible formation fibrotic myeloid-infiltrated pannus. Our aim was determine how including proximal distal ileum colon, responded changes synovium temporally coordinated manner comparing their transcriptomic landscapes using RNASeq analyses. We confirmed timeline swelling measurement, increased fluid levels bikunin (a component both acute phase protein pre-alpha-inhibitor inter-alpha-inhibitor) demonstrated self-correcting trabecular cortical bone CFA challenge. Intestine-specific responses were monitored 16S microbiome amplicon sequencing, histopathology for mucus layer integrity, immune cell immunohistochemistry. present data that shows tissue displays an allostatic region specific. primarily with secretion silencing T-cell specific pathways, whereas colon showed transient upregulation macrophages, broader suppression related metabolic pathway transcripts. Interestingly, many neuropathways activated early but then suppressed later colon. There only insignificant fecal composition or post-CFA administration. In summary, our show first time following induction minimal microbiome. results help clarify tissues stresses accompany pathogenesis diseases.

Язык: Английский

Процитировано

0
Unveiling the Hidden Link: Stomach Disease as a Risk Factor for Knee Osteoarthritis DOI Creative Commons
Xing Yang,

Xi Yang,

Ping Li

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

Abstract Background The knee joint is one of the most frequently affected joints in osteoarthritis (OA). However, specific connection between gastric diseases and occurrence (KOA) currently unclear. objective this study to explore potential association KOA using China Health Retirement Longitudinal Study (CHARLS) database. Methods A total 1053 subjects with complete information 2018 from CHARLS database were included. First, baseline characteristics these (covariates such as gender, residence, smoke) compared. Then, relationship stomach was explored through 3 weighted multivariate logistic regression models. Afterwards, risk stratification analyses taken further confirm stability correlation disease different populations. receiver operating characteristic (ROC) curve model plotted verify predictive efficiency risk. Results we divided into 2 groups: group (n = 71) control 982). table revealed that substantial differences heart attack, kidney illness, disease, well health status groups. Model 1 had an odds ratio (OR) 3.05 (95% confidence interval (CI) 1.75–5.30, P < 0.001). After adjusting for location, smoke, 2's OR 3.02 CI 1.73–5.28, P 0.001), while 3's 2.48 1.37–4.47, 0.002). models demonstrated significantly associated a factor KOA, other covariates did not change relationship. Risk indicated stable across area under (AUC) 0.722, indicating good accuracy. Conclusion In study, furtherly certified which provided reference analysis them.

Язык: Английский

Процитировано

0