Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
Abstract
Osteoarthritis
(OA)
is
a
common
degenerative
joint
disease
with
complex
risk
factors
and
an
unclear
pathogenesis.
The
onset
insidious,
mild
early
symptoms,
the
progression
irreversible.
Current
treatment
options
cannot
completely
cure
disease.
Therefore,
development
of
novel
therapeutic
approaches
prevention
strategies
crucial
for
alleviating
burden
enhancing
quality
life
patients
OA.
Extracellular
vesicles
(EVs)
naturally
possess
biocompatibility
low
immunogenicity,
showing
significant
potential
in
drug
delivery
cell-free
therapy.
To
comprehensively
understand
research
status
application
prospects
EVs
OA,
this
review
employs
bibliometric
methods
to
explore
collaboration
patterns
within
field,
current
statuses,
emerging
directions.
Additionally,
it
thoroughly
reviews
mechanisms
integration
engineering
technologies
biomaterials
enhance
their
efficacy
OA
treatment.
goal
provide
scientific
evidence
references
therapies
clinical
EVs.
Intermittent
fasting
(IF)
has
shown
benefits
in
various
pathological
conditions.
Although
its
anti-inflammatory
potential
been
recognized,
effects
on
the
mechanism
underlying
rheumatoid
arthritis
(RA)
remain
insufficiently
characterized.
This
study
aimed
to
investigate
of
IF
a
murine
model
RA.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
Abstract
Osteoarthritis
(OA)
is
a
common
degenerative
joint
disease
with
complex
risk
factors
and
an
unclear
pathogenesis.
The
onset
insidious,
mild
early
symptoms,
the
progression
irreversible.
Current
treatment
options
cannot
completely
cure
disease.
Therefore,
development
of
novel
therapeutic
approaches
prevention
strategies
crucial
for
alleviating
burden
enhancing
quality
life
patients
OA.
Extracellular
vesicles
(EVs)
naturally
possess
biocompatibility
low
immunogenicity,
showing
significant
potential
in
drug
delivery
cell-free
therapy.
To
comprehensively
understand
research
status
application
prospects
EVs
OA,
this
review
employs
bibliometric
methods
to
explore
collaboration
patterns
within
field,
current
statuses,
emerging
directions.
Additionally,
it
thoroughly
reviews
mechanisms
integration
engineering
technologies
biomaterials
enhance
their
efficacy
OA
treatment.
goal
provide
scientific
evidence
references
therapies
clinical
EVs.