Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knock-out Mice: A Novel Model for Experience-Based Depression and Post-Traumatic Stress Disorder DOI Creative Commons
Ágnes Szabó, Zsolt Galla, Eleonóra Spekker

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 26, 2024

Abstract Background: Memory and emotion are highly vulnerable to psychiatric disorders like post-traumatic stress disorder (PTSD), which has been linked serotonin (5-HT) metabolism disruptions. In fact, over 90% of the 5-HT precursor tryptophan (Trp) is metabolized via Trp-kynurenine (KYN) metabolic pathway, producing a variety bioactive molecules. The aadat (kat2) gene encodes mitochondrial kynurenine aminotransferase (KAT) isotype 2, responsible for kynurenic acid (KYNA) production. Little known about its role in behavior. Methods: CRISPR/Cas9-induced knockout (kat2−/−) mice, we examined effects on emotion, memory, motor function, Trp metabolite levels, enzyme activities plasma urine 8-week-old males compared wild-type mice. Results: Transgenic mice showed more depressive-like behaviors forced swim test, but not tail suspension, anxiety, or memory tests. They also had fewer center field corner entries, shorter walking distances, jumping counts open test. Plasma levels generally consistent with those urine: KYN, antioxidant KYNs, 5-hydroxyindolacetic acid, indole-3-acetic lower; KATs, kynureninase, monoamine oxidase/aldehyde dehydrogenase lower, 3-monooxygenase higher; oxidative excitotoxicity indices higher. Conclusion: show depression-like behavior learned helplessness model, emotional indifference, deficits, coupled decrease KYNA, shift toward KYN-3-HK partial gut microbial Trp-indole pathway metabolite. This first evidence that deleting causes unique despair experience, appears be excitatory neurotoxic stresses. may lead development double-hit preclinical model experience-based depression, better understanding these complex conditions, effective therapeutic strategies by elucidating relationship between PTSD pathogenesis.

Язык: Английский

Innovation at the Intersection: Emerging Translational Research in Neurology and Psychiatry DOI Creative Commons
Masaru Tanaka, Simone Battaglia, Lydia Giménez‐Llort

и другие.

Cells, Год журнала: 2024, Номер 13(10), С. 790 - 790

Опубликована: Май 7, 2024

Translational research in neurological and psychiatric diseases is a rapidly advancing field that promises to redefine our approach these complex conditions [...]

Язык: Английский

Процитировано

19
Innovation at the Intersection: Emerging Translational Research in Neurology and Psychiatry DOI Open Access
Masaru Tanaka, Simone Battaglia, Lydia Giménez‐Llort

и другие.

Опубликована: Апрель 17, 2024

The editorial explores the realm of emerging translational research in neurology and psychiatry, providing insights into various subjects, including neurodegenerative disorders innovative therapeutic methods. main objective is to study neurological psychiatric disorders, such as Alzheimer's disease, with a particular emphasis on techniques for neural regeneration repair. highlights importance taking comprehensive approach studying treating complex conditions. This involves thoroughly reviewing papers causes, development, biomarkers, treatment options these emphasizes necessity using multidisciplinary integrative methods gain deeper understanding improve development an animal model recurrent primary dysmenorrhea showcases employed investigation gynecological illustrating capacity connect fundamental scientific knowledge practical medical applications. cooperative endeavors researchers clinicians emphasized this lay foundation revolutionary advancements that hold potential enhance outcomes individuals afflicted globally.

Язык: Английский

Процитировано

17
A Decade of Dedication: Pioneering Perspectives on Neurological Diseases and Mental Illnesses DOI Creative Commons
Masaru Tanaka, László Vécsei

Biomedicines, Год журнала: 2024, Номер 12(5), С. 1083 - 1083

Опубликована: Май 13, 2024

Welcome to

Язык: Английский

Процитировано

17
Navigating the Neurobiology of Migraine: From Pathways to Potential Therapies DOI Creative Commons
Masaru Tanaka, Bernadett Tuka, László Vécsei

и другие.

Cells, Год журнала: 2024, Номер 13(13), С. 1098 - 1098

Опубликована: Июнь 25, 2024

Migraine is a debilitating neurological disorder characterized by recurring episodes of throbbing headaches that are frequently accompanied sensory disturbances, nausea, and sensitivity to light sound [...]

Язык: Английский

Процитировано

13
Ginkgo biloba: A Leaf of Hope in the Fight Against Alzheimer’s Dementia: Clinical Trial Systematic Review DOI Open Access

Guilherme Lopes de Oliveira Pagotto,

Livia Maria Oliveira dos Santos,

Najwa Osman

и другие.

Опубликована: Апрель 12, 2024

Alzheimer's disease (AD) is a stealthy and progressive neurological disorder that leading cause of dementia in the global elderly population, imposing significant burden on both society. Currently, condition treated with medications alleviate symptoms. Nonetheless, these drugs may not consistently produce desired results can serious side effects. Hence, there vigorous pursuit alternative options to enhance quality life for patients. Ginkgo biloba (GB), an herb historical use traditional medicine, contains bioactive compounds such as terpenoids (Ginkgolides A, B, C), polyphenols, organic acids, flavonoids (quercetin, kaempferol, isorhamnetin). These are associated anti-inflammatory, antioxidant, neuroprotective properties, making them valuable cognitive health. A systematic search across three databases using specific keywords GB AD yielded 1702 documents, selection 15 clinical trials synthesis. In eleven studies, extract/EGb 761® was shown improve function, neuropsychiatric symptoms, functional abilities types. four however, were no differences between GB-treated placebo groups. Significant improvements observed scores obtained from Mini-Mental State Examination (MMSE), Short Cognitive Performance Test (SKT), Neuropsychiatric Inventory (NPI). While majority synthesized show has promising potential conditions, more research needed determine optimal dosages, effective delivery methods, appropriate pharmaceutical formulations. Furthermore, thorough assessment adverse effects, exploration long-term implications, investigation into drug interactions critical aspects must be carefully evaluated future studies.

Язык: Английский

Процитировано

12
The Involvement of Antioxidants in Cognitive Decline and Neurodegeneration: Mens Sana in Corpore Sano DOI Creative Commons
Claudio Nazzi, Alessio Avenanti, Simone Battaglia

и другие.

Antioxidants, Год журнала: 2024, Номер 13(6), С. 701 - 701

Опубликована: Июнь 7, 2024

With neurodegenerative disorders being on the rise, a great deal of research from multiple fields is conducted in order to further knowledge and propose novel therapeutic interventions. Among these investigations, role antioxidants contrasting cognitive decline putting forward interesting promising results. In this review, we aim collect evidence that focused variety antioxidant-rich foods improving or stabilizing functions, memory, Alzheimer’s disease, most common disorder. Specifically, considered collected humans, either through longitudinal studies randomized, placebo-controlled ones, which evaluated performance, memory abilities, progression level neurodegeneration. Overall, despite between study protocols, cohorts participants involved, neuropsychological tests used, investigated antioxidants, there solid trend suggests properties may be helpful hampering older people. Thus, help future will elucidate neuroprotection lead development interventions take into account such findings provide more global approach treating disorders.

Язык: Английский

Процитировано

12
Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer’s Dementia: Clinical Trial Systematic Review DOI Creative Commons

Guilherme Lopes de Oliveira Pagotto,

Livia Maria Oliveira dos Santos,

Najwa Osman

и другие.

Antioxidants, Год журнала: 2024, Номер 13(6), С. 651 - 651

Опубликована: Май 27, 2024

Alzheimer’s disease (AD) is a stealthy and progressive neurological disorder that leading cause of dementia in the global elderly population, imposing significant burden on both society. Currently, condition treated with medications alleviate symptoms. Nonetheless, these drugs may not consistently produce desired results can serious side effects. Hence, there vigorous pursuit alternative options to enhance quality life for patients. Ginkgo biloba (GB), an herb historical use traditional medicine, contains bioactive compounds such as terpenoids (Ginkgolides A, B, C), polyphenols, organic acids, flavonoids (quercetin, kaempferol, isorhamnetin). These are associated anti-inflammatory, antioxidant, neuroprotective properties, making them valuable cognitive health. A systematic search across three databases using specific keywords—GB AD dementia—yielded 1702 documents, selection 15 clinical trials synthesis. In eleven studies, GB extract/EGb 761® was shown improve function, neuropsychiatric symptoms, functional abilities types. four however, were no differences between GB-treated placebo groups. Significant improvements observed scores obtained from Mini-Mental State Examination (MMSE), Short Cognitive Performance Test (SKT), Neuropsychiatric Inventory (NPI). While majority synthesized show has promising potential treatment conditions, more research needed determine optimal dosages, effective delivery methods, appropriate pharmaceutical formulations. Furthermore, thorough assessment adverse effects, exploration long-term implications, investigation into drug interactions critical aspects must be carefully evaluated future studies.

Язык: Английский

Процитировано

10
Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction DOI Creative Commons
Masaru Tanaka, László Vécsei

Journal of Neural Transmission, Год журнала: 2024, Номер 131(12), С. 1367 - 1387

Опубликована: Авг. 7, 2024

Millions of individuals around the world are afflicted with Parkinson's disease (PD), a prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, distinguished professor neurologist, has made substantial advancements in domain PD research, encompassing both fundamental scientific investigations practical applications. His research illuminated etiology treatment PD, as well function energy metabolism premotor symptoms. As precursor to number neurotransmitters neuromodulators that implicated pathophysiology he also investigated application tryptophan (Trp) derivatives disease. principal findings insights summarized synthesized this narrative review article, which emphasizes challenges implications for future research. This aims identify analyze key contributions Reichmann field ultimate goal informing directions domain. By examining Reichmann's work, study seeks provide comprehensive understanding his major how they can be applied advance diagnosis PD. paper explores potential intersection emerging avenues, such investigation Trp its metabolites, particularly kynurenines, could lead new therapeutic strategies managing disorders like

Язык: Английский

Процитировано

9
Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence DOI Open Access

Yandra Cervelim Nunes,

Nathalia. M. Mendes,

Enzo Pereira de Lima

и другие.

Nutrients, Год журнала: 2024, Номер 16(16), С. 2721 - 2721

Опубликована: Авг. 15, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Язык: Английский

Процитировано

8
Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress Disorder DOI Creative Commons
Ágnes Szabó, Zsolt Galla, Eleonóra Spekker

и другие.

Frontiers in Bioscience-Landmark, Год журнала: 2025, Номер 30(1)

Опубликована: Янв. 20, 2025

Backgrounds: Memory and emotion are especially vulnerable to psychiatric disorders such as post-traumatic stress disorder (PTSD), which is linked disruptions in serotonin (5-HT) metabolism. Over 90% of the 5-HT precursor tryptophan (Trp) metabolized via Trp-kynurenine (KYN) metabolic pathway, generates a variety bioactive molecules. Dysregulation KYN metabolism, particularly low levels kynurenic acid (KYNA), appears be neuropsychiatric disorders. The majority KYNA produced by aadat (kat2) gene-encoded mitochondrial kynurenine aminotransferase (KAT) isotype 2. Little known about consequences deleting enzyme gene. Methods: In CRISPR/Cas9-induced knockout (kat2-/-) mice, we examined effects on emotion, memory, motor function, Trp its metabolite levels, activities plasma urine 8-week-old males compared wild-type mice. Results: Transgenic mice showed more depressive-like behaviors forced swim test, but not tail suspension, anxiety, or memory tests. They also had fewer center field corner entries, shorter walking distances, jumping counts open test. Plasma generally consistent with those urine: antioxidant KYNs, 5-hydroxyindoleacetic acid, indole-3-acetic were lower; KATs, kynureninase, monoamine oxidase/aldehyde dehydrogenase lower, 3-monooxygenase was higher; oxidative excitotoxicity indices higher. displayed depression-like behavior learned helplessness model, emotional indifference, deficits, coupled decrease KYNA, shift metabolism toward KYN-3-hydroxykynurenine partial gut microbial Trp-indole pathway metabolite. Conclusions: This first evidence that gene induces uniquely experiences despair, appear associated excitatory neurotoxic stresses. may lead development double-hit preclinical model despair-based depression, better understanding these complex conditions, effective therapeutic strategies elucidating relationship between PTSD pathogenesis.

Язык: Английский

Процитировано

1