Oral Toxicity and Hypotensive Influence of Sericin-Derived Oligopeptides (SDOs) from Yellow Silk Cocoons of Bombyx mori in Rodent Studies DOI Creative Commons
Chainarong Tocharus,

Virakboth Prum,

Manote Sutheerawattananonda

и другие.

Foods, Год журнала: 2024, Номер 13(21), С. 3505 - 3505

Опубликована: Ноя. 1, 2024

Sericin-derived oligopeptides (SDOs) from yellow silk cocoons exhibit antihypertensive and hypoglycemic properties in both vitro vivo studies. This study investigated the acute toxicity of SDOs as a novel food for human consumption using female ICR mice Wistar rats, well chronic test on sexes rats. Clinical chemistry, hematology, histopathological studies revealed that were safe single dose 2000 mg kg-1 body weight (BW) daily oral administration 50, 100, 200 BW six months. The additionally measured rats' systolic blood pressure (SBP) sugar monthly they slowly aged. In 2nd month male rats 4th sexes, had significant hypotensive effect pressure, lowering it 130 mmHg to plateau at 110-115 mmHg. contrast, control exceeded 140 after five Nonetheless, was not observed. Measurements SBP glucose aged during tests yielded insights beyond ordinary toxicity, including health fitness lab perhaps resulting discoveries or areas justify sacrifice animals' lives.

Язык: Английский

Oral Toxicity and Hypotensive Influence of Sericin-Derived Oligopeptides (SDOs) from Yellow Silk Cocoons of Bombyx mori in Rodent Studies DOI Creative Commons
Chainarong Tocharus,

Virakboth Prum,

Manote Sutheerawattananonda

и другие.

Foods, Год журнала: 2024, Номер 13(21), С. 3505 - 3505

Опубликована: Ноя. 1, 2024

Sericin-derived oligopeptides (SDOs) from yellow silk cocoons exhibit antihypertensive and hypoglycemic properties in both vitro vivo studies. This study investigated the acute toxicity of SDOs as a novel food for human consumption using female ICR mice Wistar rats, well chronic test on sexes rats. Clinical chemistry, hematology, histopathological studies revealed that were safe single dose 2000 mg kg-1 body weight (BW) daily oral administration 50, 100, 200 BW six months. The additionally measured rats' systolic blood pressure (SBP) sugar monthly they slowly aged. In 2nd month male rats 4th sexes, had significant hypotensive effect pressure, lowering it 130 mmHg to plateau at 110-115 mmHg. contrast, control exceeded 140 after five Nonetheless, was not observed. Measurements SBP glucose aged during tests yielded insights beyond ordinary toxicity, including health fitness lab perhaps resulting discoveries or areas justify sacrifice animals' lives.

Язык: Английский

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