Antioxidants,
Год журнала:
2024,
Номер
13(6), С. 744 - 744
Опубликована: Июнь 20, 2024
Selenosugars
are
gaining
growing
interest
due
to
their
antioxidant
efficacy,
and
ability
inhibit
glycosidases,
repair
skin
tissue
or
reduce
endothelial
dysfunction.
Among
selenosugars,
those
in
which
selenium
replaces
heterocyclic
oxygen
a
5-membered
sugar
were
our
focus,
coupling
with
phenolic
compounds
appears
be
strategy
aimed
at
producing
new
enhanced
efficacy.
In
this
context,
the
Mitsunobu
reaction
has
been
advantageously
explored
obtain
trans-p-coumaroyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose,
trans-caffeoyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose,
trans-feruloyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose.
These
underwent
removal
of
iso-propylidene
group,
provide
corresponding
hydroxycinnamoyl-1,4-deoxy-4-seleno-d-ribose.
All
characterized
by
Nuclear
Magnetic
Resonance
(NMR)
spectroscopy
High-Resolution
Mass
Spectrometry
(HRMS).
This
latter
technique
was
pivotal
for
ensuing
cellular
metabolomics
analyses.
fact,
after
evaluating
anti-radical
efficacy
through
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic
acid)
(ABTS)
methods,
underline
massive
role
moiety
establishing
compounds,
whose
cytotoxicity
first
screened
two
highly
oxidative-stress-sensitive
cells,
tested
wound
healing
properties
towards
human
HaCaT
keratinocytes
cells.
Caffeoyl-
feruloyl
selenosugars
exerted
dose-dependent
activity,
while,
as
highlighted
metabolomic
approach,
they
poorly
taken
up
within
Applied Sciences,
Год журнала:
2025,
Номер
15(2), С. 796 - 796
Опубликована: Янв. 15, 2025
Vitamin
D,
also
called
the
“sunshine”
vitamin,
has
gained
great
attention
recently
due
to
observed
high
percentage
of
worldwide
population
being
deficient
in
this
essential
bioactive
vitamin.
Primarily,
vitamin
D
was
known
for
its
important
role
bone
health.
Nevertheless,
recent
research
shown
importance
brain,
heart,
muscles,
immune
system,
and
skin
health,
distinct
bio-functionality
almost
every
tissue
human
body.
Therefore,
deficiency
been
highly
correlated
with
multiple
diseases,
including
dermatologically
associated
ones.
Moreover,
different
methodologies
are
applied
synthesize
while
main
sources
plasma
levels
factors
that
can
cause
adverse
modifications
multiple.
Further
upon
exhibited
notable
against
such
as
psoriasis,
atopic
dermatitis,
vitiligo,
acne,
rosacea.
In
article,
a
critical
review
most
relevant
significant
information
regarding
relationship
between
health
is
thoroughly
conducted,
emphasis
given
potential
uses
benefits
several
cosmetic
applications.
Current
status,
limitations,
future
perspectives
potent
extensively
discussed.
Exploration of Immunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Wound
healing
is
an
area
of
growing
importance
in
the
healthcare
field,
especially
chronic
wounds
associated
with
comorbidities
like
diabetes
mellitus
(DM),
hypoxic
stress,
obesity,
and
malnutrition.
Chronic
significantly
increase
costs
reduce
patients’
quality
life.
Cytokines
are
a
promising
therapeutic
target,
as
they
regulate
all
stages
wound
healing,
dysfunction
cytokine
production
can
cause
inflammatory
non-healing
wounds.
Interleukin-1
(IL-1),
IL-2,
IL-6,
IL-8,
tumour
necrosis
factor-α
(TNF-α)
facilitate
leukocyte
recruitment
clear
dead
cells
during
initial
inflammation
stage
while
transforming
growth
factor-β
(TGF-β),
IL-4,
IL-13
inhibit
stimulate
proliferation
fibroblasts
to
begin
extracellular
matrix
(ECM)
deposition.
Given
complexity
interactions
their
diverse
cellular
targets,
comprehensive
understanding
these
signaling
pathways
crucial.
This
review
examines
multifaceted
roles
cytokines
discusses
recent
advancements
application
modulation
for
improved
care
outcomes.
Despite
significant
improving
specificity
therapies,
further
research
needed
focus
on
targeting
downstream
or
specific
receptors
minimize
adverse
effects
treatments.
Polymers,
Год журнала:
2025,
Номер
17(1), С. 108 - 108
Опубликована: Янв. 2, 2025
Disruption
of
the
molecular
pathways
during
physiological
wound
healing
can
lead
to
raised
scar
formation,
characterized
by
rigid,
thick
tissue
with
associated
symptoms
pain
and
pruritus.
A
key
mechanical
factor
in
development
is
excessive
tension
at
site.
Recently,
microneedles
(MNs)
have
emerged
as
promising
tools
for
management
they
engage
provide
them
off-loading
from
both
internal
external
sources.
This
review
explores
mechanisms
which
physical
intervention
drug-free
MNs
alleviates
on
fibroblasts
within
tissue,
thereby
promoting
remodeling
reducing
severity.
Additionally,
role
an
efficient
cargo
delivery
system
controlled
sustained
release
a
wide
range
therapeutic
agents
into
highlighted.
By
penetrating
facilitate
localized
drug
administration
modulate
inflammation
fibroblastic
cell
growth.
Finally,
remaining
challenges
future
perspective
field
been
Abstract
The
capacity
for
tissue
repair
during
wound
healing
declines
with
age.
A
chronic
low
but
systemic
inflammatory
status,
often
called
“inflammaging”,
is
considered
a
key
factor
that
contributes
to
impaired
regeneration.
This
phenomenon
has
been
substantiated
by
an
increased
number
of
immune
cells
in
wound-tissue
old
mice.
Although
coordinate
response
their
secretome
the
composition
milieu
not
examined.
In
young
(2
months)
and
(18
female
mice,
excision
wounds
were
induced
using
punch
biopsy
device,
i.e.,
progress
occurred
through
secondary
intention.
closure
rate
was
analyzed
7
days.
At
days
1,
3
post-surgery,
specimen
investigated
immunohistochemical
detection
granulocytes,
M1-macrophages
mesenchymal
stem
skin.
concentrations
cytokines
regenerative
growth
factors
determined
homogenates
ELISA.
carbonyl
assay
used
determine
protein
oxidation.
delayed
between
1
as
peak
cell
infiltration.
There
no
age
effect
on
concentration
cytokines,
animals
contained
higher
levels
factors.
Protein
oxidation
present
study
suggests
reduced
rather
than
enhanced
score
affected
regeneration
process
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1769 - 1769
Опубликована: Фев. 19, 2025
PDRN,
polydeoxyribonucleotide,
which
is
used
as
a
tissue-regeneration
material,
present
in
human
cells
under
physiological
conditions
and
stimulates
regeneration
metabolic
activity.
PDRN
can
be
biomaterial
for
several
types
of
regeneration,
including
wound
healing,
to
promote
cell
growth
growth-factor
production.
The
aims
this
study
were
determine
the
effect
derived
from
placenta-derived
mesenchymal
stem
(hPD-MSCs)
on
cellular
through
A2A
receptor
signaling
investigate
its
therapeutic
effects
mouse
model
healing.
Human
(UNIPlax)
was
extracted
hPD-MSCs
fragmented
via
sonication
system
evaluated
migration
HaCaT
an
vitro
wound-healing
vivo.
Compared
with
sham
treatment,
UNIPlax
treatment
significantly
increased
injured
(p
<
0.05).
Additionally,
tube
formation
umbilical
vein
endothelial
(HUVECs)
greater
than
that
group
0.05),
mediated
receptor.
Furthermore,
led
decrease
size;
addition,
area
granulation
rate
collagen
at
site
those
0.001).
We
also
confirmed
promoted
tissue
expression
VEGF
Taken
together,
these
findings
indicate
has
potential
damaged
tissues,
during
Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 582 - 582
Опубликована: Фев. 26, 2025
Background/Objectives:
Chronic
wounds
represent
a
growing
challenge
for
the
aging
population,
significantly
impairing
their
quality
of
life,
increasing
frequency
medical
consultations,
and
imposing
substantial
healthcare
costs.
are
prone
to
complications,
including
local
systemic
infections,
in
severe
cases,
amputations.
The
therapeutic
use
live
larvae
from
blowfly
Lucilia
sericata
(biological
debridement)
has
regained
attention
its
ability
debride
necrotic
tissue
stimulate
granulation.
Despite
benefits,
this
therapy
is
constrained
by
logistical
challenges
producing
delivering
patient
adherence
issues.
Objectives:
This
study
aimed
develop
lyophilized
extract
evaluate
efficacy
treating
chronic
wounds.
Methods:
A
maggot
(Larveel®,
Alpha-Biocare
GmbH,
Neuss,
Germany)
was
produced
under
GMP
conditions.
In
total
ten
patients
with
refractory
wounds,
used
individual
trials
effect
on
bacterial
colonization
wound
healing
investigated.
Wound
documented
photographically
measured
visually
terms
reduction
slough,
an
increase
granulation
tissue,
area.
Results:
Of
patients,
three
discontinued
treatment
due
P.
aeruginosa
colonization.
seven
significant
fibrin
reduction,
granulation,
occurred,
two
achieving
complete
closure
four
showing
advanced
epithelialization.
Conclusions:
7
10
application
led
marked
improved
progression
healing.
These
effects
likely
attributable
extract’s
disrupt
biofilm
formation.
findings
suggest
that
novel
approach
may
provide
practical
effective
alternative
larval
managing
