Antioxidants,
Год журнала:
2024,
Номер
13(6), С. 744 - 744
Опубликована: Июнь 20, 2024
Selenosugars
are
gaining
growing
interest
due
to
their
antioxidant
efficacy,
and
ability
inhibit
glycosidases,
repair
skin
tissue
or
reduce
endothelial
dysfunction.
Among
selenosugars,
those
in
which
selenium
replaces
heterocyclic
oxygen
a
5-membered
sugar
were
our
focus,
coupling
with
phenolic
compounds
appears
be
strategy
aimed
at
producing
new
enhanced
efficacy.
In
this
context,
the
Mitsunobu
reaction
has
been
advantageously
explored
obtain
trans-p-coumaroyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose,
trans-caffeoyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose,
trans-feruloyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose.
These
underwent
removal
of
iso-propylidene
group,
provide
corresponding
hydroxycinnamoyl-1,4-deoxy-4-seleno-d-ribose.
All
characterized
by
Nuclear
Magnetic
Resonance
(NMR)
spectroscopy
High-Resolution
Mass
Spectrometry
(HRMS).
This
latter
technique
was
pivotal
for
ensuing
cellular
metabolomics
analyses.
fact,
after
evaluating
anti-radical
efficacy
through
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic
acid)
(ABTS)
methods,
underline
massive
role
moiety
establishing
compounds,
whose
cytotoxicity
first
screened
two
highly
oxidative-stress-sensitive
cells,
tested
wound
healing
properties
towards
human
HaCaT
keratinocytes
cells.
Caffeoyl-
feruloyl
selenosugars
exerted
dose-dependent
activity,
while,
as
highlighted
metabolomic
approach,
they
poorly
taken
up
within
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 416 - 416
Опубликована: Март 15, 2025
Background:
This
study
explores
wound
healing
and
the
antimicrobial
potential
of
a
natural
formulation
containing
polysaccharide
extract
from
Cerioporus
squamosus,
hyaluronic
acid,
dexpanthenol.
Methods:
Wound
effects
were
assessed
using
HaCaT
keratinocytes,
while
activity
was
evaluated
against
human
skin
pathogens
microdilution
assay.
In
vitro
cytotoxicity
tests
ensured
safety,
whereas
in
vivo
further
investigated
an
animal
model.
Gene
expression
analysis
performed
to
assess
molecular
mechanisms
involved.
Results:
The
unique
glucan
composition
C.
squamosus
(15.38%
α-glucans
7.91%
β-glucans)
deviated
typical
mushroom
profiles,
warranting
exploration
its
bioactivity.
polysaccharides
promoted
25.35%
closure
after
24
hours,
three-component
achieved
35.81%
closure.
Antibacterial
showed
minimum
inhibitory
concentration
(MIC)
0.44–1.75
mg/mL
bactericidal
(MBCs)
0.88–3.50
mg/mL,
antifungal
ranged
0.22
0.44
(MICs)
0.88
(minimum
fungicidal
concentration—MFC).
data
that
60%
treated
wounds
fully
closed
by
day
11,
despite
no
statistically
significant
difference
control.
However,
gene
highlighted
VEGF
collagen
upregulation,
indicating
enhancement
on
level.
Conclusions:
novel
demonstrated
consistent
properties,
supporting
as
safe
effective
treatment
for
chronic
acute
wounds.
Materials,
Год журнала:
2025,
Номер
18(6), С. 1377 - 1377
Опубликована: Март 20, 2025
Additive
manufacturing
is
transforming
modern
industries
by
enabling
the
production
of
lightweight,
complex
structures
while
minimizing
material
waste
and
energy
consumption.
This
review
explores
its
evolution,
covering
historical
developments,
key
technologies,
emerging
trends.
It
highlights
advancements
in
innovations,
including
metals,
polymers,
composites,
ceramics,
tailored
to
enhance
mechanical
properties
expand
functional
applications.
Special
emphasis
given
bioinspired
designs
their
contribution
enhancing
structural
efficiency.
Additionally,
potential
these
techniques
for
sustainable
industrial
scalability
discussed.
The
findings
contribute
a
broader
understanding
Manufacturing’s
impact
on
design
optimization
performance,
offering
insights
into
future
research
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2976 - 2976
Опубликована: Март 25, 2025
Pterygium
is
a
condition
affecting
the
ocular
surface,
marked
by
triangular-shaped
growth
of
fibrotic
tissue
extending
from
nasal
conjunctiva
toward
corneal
center,
potentially
causing
visual
impairment.
While
ultraviolet
(UV
)light
exposure
primary
risk
factor
for
pterygium,
its
underlying
cause
remains
unclear.
In
order
to
better
understand
true
genesis
pterygium
development,
we
investigated
and
compared
it
with
healthy
controls.
Given
eye's
direct
environmental
exposure,
analyzed
microbiota
composition
using
metagenomic
sequencing
identify
microbes
associated
this
condition.
Metagenomic
revealed
higher
prevalence
fungus
Malassezia
restricta
in
five
samples,
confirmed
situ
hybridization.
The
CHIT1
gene,
which
plays
role
antifungal
defenses,
displayed
highest
expression
samples
controls,
suggesting
potential
involvement
development.
Gene
profiling
highlighted
an
IL-33
IL-4
gene
signature,
along
increased
presence
M2
macrophages,
emphasizing
their
promoting
fibrosis-a
hallmark
feature
pterygium.
detection
molecular
changes
provides
novel
insights
into
microbiome
raises
possibility
Malassezia's
pathology.
ACS Omega,
Год журнала:
2025,
Номер
10(13), С. 12837 - 12855
Опубликована: Март 28, 2025
The
skin
plays
a
crucial
role
in
the
body's
homeostasis
through
its
thermoregulation
functions,
metabolic
activity,
and,
mainly,
barrier
function.
Once
this
system
has
disturbed,
promotion
of
tissue
discontinuity,
an
injury
happens
and
restoration
process
starts.
Different
products
can
be
used
to
promote,
accelerate,
or
stimulate
healing
process,
such
as
hydrogels,
emulsions,
ointments
(main
conventional
formulations).
Despite
historical
use
wide
market
consumer
acceptance,
new
systems
emerged
for
wound
management
with
main
challenge
overcome
form
limitations,
which
nanosystems
are
found,
mainly
nanobased
emulsion
forms
(nano-
microemulsions,
NE
ME).
Here,
we
discuss
function
highlighting
cellular
molecular
processes,
different
classifications,
factors
that
affect
physiological
healing.
We
also
investigated
recent
patents
(2012-2023)
filed
at
United
States
Patent
Trademark
Office,
where
found
few
(hydrogels
=
5;
emulsions
4;
6)
but
larger
number
time
(NE
638;
ME
4,072).
Furthermore,
address
ME)
their
particularities,
differences,
application
treatment.
This
work
discusses
challenges,
bottlenecks,
regulatory
framework
nanosystems,
industrial,
academic,
government
interest
nanotechnology,
future
perspectives
about
key
factor
acceptance.
Archives of Dermatological Research,
Год журнала:
2025,
Номер
317(1)
Опубликована: Апрель 13, 2025
Since
olden
days,
medicinal
and
aromatic
plants
have
been
consumed
due
to
their
well-known
therapeutic,
ornamental,
culinary,
cosmetic
properties.
Plant-based
cosmetics
comprise
a
growing
market
offering
brands
of
sustainable
products
with
the
ultimate
goal
responding
woman
needs
boost
natural
beauty,
such
as
soothing,
toning,
moisturizing
protecting
skin
hair.
The
increasing
focus
on
body
beauty
care,
combined
better
understanding
diverse
biological
effects
derivatives,
has
revitalized
significance
in
aesthetic,
cosmetic,
dermatological
contexts.
Concurrently,
prevalence
allergies
hypersensitivity
reactions
synthetic
additives
commonly
found
other
spurred
interest
seeking
healthier
more
efficacious
alternatives.
An
intense
investigation
stated
around
formulation
plants-
plant-based
for
aesthetic
purposes.
Similarly,
raising
awareness
by
cosmetics'
manufacturers
related
industries
progressively
stated,
culminating
emergence
line
increasingly
safe
reliable
quality
features
multiple
Although
high
demand
natural-based
purposes
further
studies
are
required
deepening
knowledge
beneficial
properties,
safety
identify
main
limitations
likelihood
side
occurrence.
In
this
review,
an
outlook
current
scenario
regarding
use
ingredients
care
traditionally
used
Mediterranean
prevention
even
cure
hair
diseases
or
beautification
is
provided.
International Wound Journal,
Год журнала:
2025,
Номер
22(4)
Опубликована: Апрель 1, 2025
ABSTRACT
The
aim
of
this
study
was
to
evaluate
the
effects
a
high‐capillarity
dressing
on
chronic
wound
healing,
using
hyperspectral
imaging
assess
biophysical
parameters.
This
quasi‐experimental
pilot
involved
eight
adults
with
ulcers
treated
for
4
weeks.
Primary
outcomes
included
pH,
temperature,
and
oxygen
saturation,
measured
imaging,
along
area
assessed
ImageJ.
Secondary
quality
life,
evaluated
EQ‐5D‐5L
Wound
QoL‐17
scales.
Data
were
collected
at
baseline,
7,
14,
21
days,
analysed
SPSS.
Results
showed
significant
reduction
in
lesion
size
(
p
<
0.05)
pain
0.001)
following
treatment.
Biophysical
assessments
revealed
decrease
pH
=
0.004),
but
no
changes
observed
other
parameters
(oxygen
NIR,
TWI,
TLI).
A
correlation
found
between
saturation
0.005).
results
suggest
that
improves
healing
by
reducing
size,
promoting
acidification,
improving
superficial
oxygenation.
Additionally,
controlled
edema
eliminated
infection
signs
without
antibiotics,
suggesting
its
potential
optimising
environment.
These
findings
highlight
need
further
research
into
clinical
application
management.
