Antioxidants,
Год журнала:
2024,
Номер
13(6), С. 744 - 744
Опубликована: Июнь 20, 2024
Selenosugars
are
gaining
growing
interest
due
to
their
antioxidant
efficacy,
and
ability
inhibit
glycosidases,
repair
skin
tissue
or
reduce
endothelial
dysfunction.
Among
selenosugars,
those
in
which
selenium
replaces
heterocyclic
oxygen
a
5-membered
sugar
were
our
focus,
coupling
with
phenolic
compounds
appears
be
strategy
aimed
at
producing
new
enhanced
efficacy.
In
this
context,
the
Mitsunobu
reaction
has
been
advantageously
explored
obtain
trans-p-coumaroyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose,
trans-caffeoyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose,
trans-feruloyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose.
These
underwent
removal
of
iso-propylidene
group,
provide
corresponding
hydroxycinnamoyl-1,4-deoxy-4-seleno-d-ribose.
All
characterized
by
Nuclear
Magnetic
Resonance
(NMR)
spectroscopy
High-Resolution
Mass
Spectrometry
(HRMS).
This
latter
technique
was
pivotal
for
ensuing
cellular
metabolomics
analyses.
fact,
after
evaluating
anti-radical
efficacy
through
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic
acid)
(ABTS)
methods,
underline
massive
role
moiety
establishing
compounds,
whose
cytotoxicity
first
screened
two
highly
oxidative-stress-sensitive
cells,
tested
wound
healing
properties
towards
human
HaCaT
keratinocytes
cells.
Caffeoyl-
feruloyl
selenosugars
exerted
dose-dependent
activity,
while,
as
highlighted
metabolomic
approach,
they
poorly
taken
up
within
Pharmaceuticals,
Год журнала:
2024,
Номер
17(10), С. 1305 - 1305
Опубликована: Сен. 30, 2024
Non-healing
diabetic
wounds
represent
a
significant
clinical
challenge
globally,
necessitating
innovative
approaches
in
drug
delivery
to
enhance
wound
healing.
Understanding
the
pathogenesis
of
these
is
crucial
for
developing
effective
treatments.
Bioactive
dressings
and
polymeric
nanofibers
have
emerged
as
promising
modalities,
with
silk
biomaterials
gaining
attention
their
unique
properties
Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1426 - 1426
Опубликована: Ноя. 8, 2024
The
demand
for
natural-based
formulations
in
chronic
wound
care
has
increased,
driven
by
the
need
biocompatible,
safe,
and
effective
treatments.
Natural
polysaccharide-based
emulsions
enriched
with
vegetable
oils
present
promising
benefits
skin
repair,
offering
structural
support
protective
barriers
suitable
sensitive
environments.
This
study
aimed
to
develop
evaluate
semisolid
healing,
incorporating
avocado
(
Antioxidants,
Год журнала:
2024,
Номер
13(6), С. 744 - 744
Опубликована: Июнь 20, 2024
Selenosugars
are
gaining
growing
interest
due
to
their
antioxidant
efficacy,
and
ability
inhibit
glycosidases,
repair
skin
tissue
or
reduce
endothelial
dysfunction.
Among
selenosugars,
those
in
which
selenium
replaces
heterocyclic
oxygen
a
5-membered
sugar
were
our
focus,
coupling
with
phenolic
compounds
appears
be
strategy
aimed
at
producing
new
enhanced
efficacy.
In
this
context,
the
Mitsunobu
reaction
has
been
advantageously
explored
obtain
trans-p-coumaroyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose,
trans-caffeoyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose,
trans-feruloyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose.
These
underwent
removal
of
iso-propylidene
group,
provide
corresponding
hydroxycinnamoyl-1,4-deoxy-4-seleno-d-ribose.
All
characterized
by
Nuclear
Magnetic
Resonance
(NMR)
spectroscopy
High-Resolution
Mass
Spectrometry
(HRMS).
This
latter
technique
was
pivotal
for
ensuing
cellular
metabolomics
analyses.
fact,
after
evaluating
anti-radical
efficacy
through
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic
acid)
(ABTS)
methods,
underline
massive
role
moiety
establishing
compounds,
whose
cytotoxicity
first
screened
two
highly
oxidative-stress-sensitive
cells,
tested
wound
healing
properties
towards
human
HaCaT
keratinocytes
cells.
Caffeoyl-
feruloyl
selenosugars
exerted
dose-dependent
activity,
while,
as
highlighted
metabolomic
approach,
they
poorly
taken
up
within
