Anti-Inflammatory Effects of Cannabigerol In Vitro and In Vivo Are Mediated Through the JAK/STAT/NFκB Signaling Pathway
Cells,
Год журнала:
2025,
Номер
14(2), С. 83 - 83
Опубликована: Янв. 9, 2025
Cannabinoid
compounds
have
potential
as
treatments
for
a
variety
of
conditions,
with
cannabigerol
(CBG)
being
known
its
anti-inflammatory
properties.
In
this
study,
we
investigated
the
effects
CBG
in
cellular
model
1-chloro-2,4-dinitrobenzene
(DNCB)-induced
atopic
dermatitis
(AD).
model,
confirmed
cytotoxicity
and
downregulated
expression
inflammatory
markers
CCL26,
IL1B,
IL6,
TNF
(p
<
0.001).
mouse
clinical,
histological,
immunological
changes
were
analyzed.
The
results
showed
that
improved
severity
score,
epidermal
thickness,
mast
cell
count
reduced
cytokines
(Tslp,
Il1b,
Il4,
Il6,
Il13,
Il17,
Il18,
Il22,
Il33)
by
qRT-PCR
Western
blot
modulated
JAK1,
JAK2,
TYK2,
STAT1,
STAT2,
STAT3,
p-STAT3,
STAT6,
p-STAT6
0.05).
Subsequently,
p-IκBα,
NF-κB,
p-NF-κB
signaling
factors
also
0.05),
corresponding
skin
barrier
factors.
study
indicate
effectively
alleviates
AD-like
symptoms
suggest
therapeutic
agent.
Язык: Английский
Cannabis-Based Phytocannabinoids: Overview, Mechanism of Action, Therapeutic Application, Production, and Affecting Environmental Factors
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11258 - 11258
Опубликована: Окт. 19, 2024
This
review
provides
an
overview
of
cannabis-based
phytocannabinoids,
focusing
on
their
mechanisms
action,
therapeutic
applications,
and
production
processes,
along
with
the
environmental
factors
that
affect
quality
efficacy.
Phytocannabinoids
such
as
THC
(∆9-tetrahydrocannabinol),
CBD
(cannabidiol),
CBG
(cannabigerol),
CBN
(cannabinol),
CBC
(cannabichromene)
exhibit
significant
potential
in
treating
various
physical
mental
health
conditions,
including
chronic
pain,
epilepsy,
neurodegenerative
diseases,
skin
disorders,
anxiety.
The
cultivation
cannabis
plays
a
crucial
role
determining
cannabinoid
profiles,
indoor
offering
more
control
consistency
than
outdoor
methods.
Environmental
light,
water,
temperature,
humidity,
nutrient
management,
CO2,
drying
method
used
are
key
to
optimizing
content
inflorescences.
outlines
need
for
broader
data
transfer
between
industry
technological
production,
especially
terms
what
concentration
ratios
effective
treatment.
Such
would
provide
cultivators
information
parameters
should
be
manipulated
obtain
required
final
product.
Язык: Английский
Cannabinoids—Multifunctional Compounds, Applications and Challenges—Mini Review
Molecules,
Год журнала:
2024,
Номер
29(20), С. 4923 - 4923
Опубликована: Окт. 17, 2024
Cannabinoids
represent
a
highly
researched
group
of
plant-derived
ingredients.
The
substantial
investment
funds
from
state
and
commercial
sources
has
facilitated
significant
increase
in
knowledge
about
these
can
be
classified
into
three
principal
categories:
phytocannabinoids,
synthetic
cannabinoids
endogenous
cannabinoids,
along
with
the
enzymes
responsible
for
their
synthesis
degradation.
All
compounds
interact
biologically
type
1
(CB1)
and/or
2
(CB2)
cannabinoid
receptors.
A
body
evidence
vitro
vivo
studies
demonstrated
that
inhibitors
endocannabinoid
degradation
possess
anti-inflammatory,
antioxidant,
antitumour
antifibrotic
properties
beneficial
effects.
This
review,
which
spans
period
1940
to
2024,
offers
an
overview
potential
therapeutic
applications
natural
cannabinoids.
development
substances
is
essential
global
market
do-it-yourself
drugs
fully
exploit
promising
Язык: Английский
Cannabinoids: Potential for Modulation and Enhancement When Combined with Vitamin B12 in Case of Neurodegenerative Disorders
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 813 - 813
Опубликована: Июнь 20, 2024
The
enduring
relationship
between
humanity
and
the
cannabis
plant
has
witnessed
significant
transformations,
particularly
with
widespread
legalization
of
medical
cannabis.
This
led
to
recognition
diverse
pharmacological
formulations
cannabis,
containing
545
identified
natural
compounds,
including
144
phytocannabinoids
like
Δ9-THC
CBD.
Cannabinoids
exert
distinct
regulatory
effects
on
physiological
processes,
prompting
their
investigation
in
neurodegenerative
diseases.
Recent
research
highlights
potential
modulating
protein
aggregation
mitochondrial
dysfunction,
crucial
factors
conditions
such
as
Alzheimer’s
Disease,
multiple
sclerosis,
or
Parkinson’s
disease.
discussion
emphasizes
importance
maintaining
homeodynamics
disorders
explores
innovative
therapeutic
approaches
nanoparticles
RNA
aptamers.
Moreover,
cannabinoids,
CBD,
demonstrate
anti-inflammatory
through
modulation
microglial
activity,
offering
multifaceted
neuroprotection
mitigating
aggregation.
Additionally,
integration
cannabinoids
vitamin
B12
presents
a
holistic
framework
for
addressing
neurodegeneration,
considering
roles
nervous
system
functioning
hippocampal
neurogenesis.
synergistic
benefits
combining
CBD
underscore
promising
avenue
advancing
treatment
strategies
However,
further
is
imperative
fully
elucidate
applications,
emphasizing
dynamic
nature
this
field
its
reshape
disease
paradigms.
Язык: Английский