Diagnostic and Therapeutic Utility of Extracellular Vesicles in Ocular Disease

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 836 - 836

Опубликована: Янв. 20, 2025

Extracellular vesicles (EVs) are lipid bilayer particles released by virtually all cells, with prominent roles in both physiological and pathological processes. The size, number, molecular composition of EVs correlate to the cells origin, modulated cell’s environment pathologic state. proteins, DNA, RNA, protein cargo carried protected degradation, a role targeted intercellular signaling. These properties make salient targets as carriers biomarkers potential therapeutic delivery vehicles. majority EV research has focused on blood, urine, saliva, cerebrospinal fluid due easy accessibility. have also been identified studied ocular biofluids, including vitreous humor, aqueous tear film, study disease is new, promising, underexplored direction unique challenges considerations. This review covers recent advances diagnostic use EVs, focus human applications key preceding vitro vivo animal studies. We discuss future directions based other organ systems sates.

Язык: Английский

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Extracellular vesicles: new horizons in neurodegeneration

EBioMedicine, Год журнала: 2025, Номер 113, С. 105605 - 105605

Опубликована: Март 1, 2025

Extracellular vesicles (EVs) are lipid-enclosed nanovesicles secreted by diverse cell types that orchestrate intercellular communication through cargo delivery. Their pivotal roles span from supporting the development of normal central nervous system (CNS) to contributing pathogenesis neurological diseases. Particularly noteworthy is their involvement in propagation pathogenic proteins, such as those involved neurodegenerative disorders, and nucleic acids, closely linking them disease onset progression. Moreover, EVs have emerged promising diagnostic biomarkers for disorders tools staging, owing ability traverse blood-brain barrier specific, stable, accessible properties. This review comprehensively explores realm CNS-derived found peripheral blood, encompassing detection methods, transport mechanisms, various Furthermore, we evaluate potentials limitations clinical applications highlight prospective research directions this rapidly evolving field.

Язык: Английский

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Extracellular vesicles: translational research and applications in neurology

Nature Reviews Neurology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Язык: Английский

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Proposing Bromo-Epi-Androsterone for Neurologic Long-COVID

Опубликована: Июль 1, 2024

The neurologic effects of long-COVID are a therapeutic challenge. This article discusses the immunologic manifestations and proposes non-androgenic, synthetic analog dehydroepiandrosterone (DHEA), bromo-epi-androsterone (BEA), as candidate for clinical trials this exigent collection conditions. Moreover, because there is an association between Alzheimer’s disease, evaluation BEA in may serve proxy its effect on neuroinflammatory biomarkers disease that shared with long-COVID.

Язык: Английский

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Microfluidics in neural extracellular vesicles characterization for early Alzheimer's disease diagnosis

Molecular and Cellular Neuroscience, Год журнала: 2024, Номер 132, С. 103982 - 103982

Опубликована: Дек. 3, 2024

Язык: Английский

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Positive Effect of YB-1 and Mesenchymal Stromal Cells on Primary Hippocampal Culture under Conditions of ACE2 Receptor Blockade

Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology, Год журнала: 2024, Номер 18(S1), С. S20 - S32

Опубликована: Дек. 1, 2024

Язык: Английский

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