Identification of a Cancer Stem Cell-Related Gene Signature in Hepatocellular Carcinoma Based on Single-Cell RNA-Seq and Bulk RNA-Seq Analysis

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2933 - 2933

Опубликована: Март 24, 2025

Cancer stem cells (CSCs) are a heterogeneous group of tumor that play significant role in tumorigenesis, therapeutic resistance, and recurrence liver hepatocellular carcinoma (LIHC). This study combines clinical data sets from The Genome Atlas (TCGA) the International Consortium (ICGC) with bulk RNA sequencing data. also features GSE156625 single-cell (scRNA) set GEO to explore prognostic significance CSC biomarkers (BCSCs) LIHC. In this research, we introduce developed risk model relies on nine specific BCSCs, including ADM, CCL5, CD274, DLGAP5, HOXD9, IGF1, S100A9, SOCS2, TNFRSF11B. It was found high-risk patients experience shorter overall survival rates when compared low-risk patients. Additionally, characterized composition immune within microenvironment (TME) revealed variations gene-expression levels mutation between different groups. suggests cancer progression might be driven by evasion independent PD-L1 highlights potential BCSC being sensitive various treatments. Our findings offer promising foundation for personalized LIHC therapy highlight need further experimental validation roles these CSCs disease progression.

Язык: Английский

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Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiency

Biotechnology Advances, Год журнала: 2025, Номер unknown, С. 108568 - 108568

Опубликована: Март 1, 2025

Язык: Английский

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Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Апрель 4, 2025

Язык: Английский

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New Insights into the Fanconi Anemia Pathogenesis: A Crosstalk Between Inflammation and Oxidative Stress

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11619 - 11619

Опубликована: Окт. 29, 2024

Fanconi anemia (FA) represents a rare hereditary disease; it develops due to germline pathogenic variants in any of the 22 currently discovered FANC genes, which interact with anemia/breast cancer-associated (FANC/BRCA) pathway maintain genome integrity. FA is characterized by triad clinical traits, including congenital anomalies, bone marrow failure (BMF) and multiple cancer susceptibility. Due complex genetic background broad spectrum symptoms, diagnostic process requires use classical cytogenetic, molecular cytogenetics strictly methods. Recent findings indicate interplay inflammation, oxidative stress, disrupted mitochondrial metabolism, impaired intracellular signaling pathogenesis. Additionally, shift balance towards overproduction proinflammatory cytokines prooxidant components associated advanced myelosuppression ultimately BMF. Although mechanism BMF very needs further clarification, appears that mutual interaction between redox imbalance causes pancytopenia. In this review, we summarize available literature regarding phenotype, background, procedures FA. We also highlight current understanding autophagy process, state, pathways genotoxic stress

Язык: Английский

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UV radiation enhanced encapsulation of superparamagnetic iron oxide nanoparticles (MNPs) in microparticles derived from tumor repopulating cells

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 741, С. 151050 - 151050

Опубликована: Ноя. 22, 2024

Язык: Английский

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