Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2514 - 2514
Опубликована: Ноя. 3, 2024
Background/Objectives:
Neuroinflammation
is
associated
with
the
progression
of
various
brain
diseases,
and
management
neuroinflammation-induced
neural
damage
a
crucial
aspect
treating
neurological
disorders.
This
study
investigated
anti-inflammatory
efficacy
photobiomodulation
therapy
(PBMT)
using
660
nm
phototherapy
in
rat
model
lipopolysaccharide
(LPS)-induced
neuroinflammation.
Methods:
We
induced
inflammation
brains
via
intraperitoneal
injection
LPS
subjected
treatment
group
to
examine
its
protective
effect
against
hippocampal
based
on
pathological,
histological,
immunohistochemical
tissue
analyses.
Results:
The
treated
rats
showed
significant
decrease
structural
cell
death
compared
LPS-treated
group.
observed
reduced
expression
markers
GFAP,
TNF-α,
IL-1β
hippocampus
group,
an
increase
SIRT1
across
all
regions.
Conclusions:
presents
promising
method
for
controlling
neuroinflammation
providing
neuroprotection
relief.
PBMT
represents
non-invasive
therapeutic
approach
minimal
side
effects
ensured
through
proper
control
light
irradiation.
Medicina,
Год журнала:
2024,
Номер
60(10), С. 1682 - 1682
Опубликована: Окт. 14, 2024
Parkinson's
disease
(PD)
is
a
pathological
state
characterized
by
combined
set
of
abnormal
movements
including
slow
motion,
resting
tremors,
profound
stiffness
skeletal
muscles,
or
obvious
abnormalities
in
posture
and
gait,
together
with
significant
behavioral
changes.
Until
now,
no
single
therapeutic
modality
was
able
to
provide
complete
cure
for
PD.
This
work
trial
assess
the
immunomodulatory
effects
canagliflozin
without
levodopa/carbidopa
on
rotenone-induced
parkinsonism
Balb/c
mice.
Frontiers in Neuroanatomy,
Год журнала:
2024,
Номер
18
Опубликована: Дек. 16, 2024
Parkinson's
disease
(PD)
is
a
neurodegenerative
condition
characterized
by
the
loss
of
dopaminergic
neurons
in
substantia
nigra
pars
compacta
(SNc)
brain,
manifesting
itself
with
both
motor
and
non-motor
symptoms.
A
critical
element
this
pathology
neuroinflammation,
which
triggers
harmful
neurotoxic
cycle,
exacerbating
cell
death
within
central
nervous
system.
AD-16
(also
known
as
GIBH-130)
recently
identified
compound
capable
reducing
expression
pro-inflammatory
cytokines
while
increasing
anti-inflammatory
Alzheimer's
models.
Here,
for
first
time,
we
sought
to
comprehend
potential
impact
orally
administered
mitigating
neurodegeneration
subsequent
progression
PD.
To
accomplish
this,
6-
hydroxydopamine
(6-OHDA)
unilateral
striatal
injections
were
employed
induce
PD
model
male
C57BL/6
mice.
Cylinder
apomorphine-induced
rotation
behavior
tests
conducted
assess
validate
3
days
after
injection.
was
via
gavage
daily
between
9
surgery.
On
last
day
treatment,
performed
again.
All
animals
euthanized
on
10
immunohistochemistry
techniques
detect
tyrosine
hydroxylase
(TH)
Iba-1
thus
label
microglia
SNc
striatum
(CPu).
These
same
regions
collected
ELISA
assays
different
cytokine
concentrations.
Our
results
revealed
an
enhancement
function
AD-16-treated
animals,
well
reduced
nigrostriatal
neurodegeneration.
In
addition,
increase
density
prevented
changes
its
morphology
observed
animal
Furthermore,
able
avoid
levels
that
present
6-OHDA-injected
who
received
vehicle.
Consequently,
emerges
significant
negative
modulation
neuroinflammation
suppression
6-OHDA
disease.
Annals of Indian Academy of Neurology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 21, 2024
Abstract
Background
and
Objectives:
Parkinson’s
disease
(PD)
is
a
neurodegenerative
disorder
involving
depletion
of
dopaminergic
neurons.
Pathogenetic
mechanisms
leading
to
striatonigral
degeneration
are
debatable.
Chronic
inflammation
proposed
as
one
the
mechanisms.
In
any
with
underlying
inflammation,
immune
system
mediators
called
cytokines
released,
procoagulant
state.
Our
aim
was
study
coagulation
parameters
in
patients
PD
find
their
correlation
duration
antiparkinsonian
drugs.
Methods:
This
cross-sectional
conducted
between
January
2021
December
tertiary
care
center.
Sixty-eight
were
subcategorized
based
on
(<5
≥5
years),
number
drugs
(one
drug
≥2
drugs),
levodopa
equivalent
daily
dose
(LEDD;
<350
≥350
mg).
Hemoglobin
(Hb),
prothrombin
time
(PT),
fibrinogen,
bleeding
time,
platelet
aggregation
adenosine
diphosphate
collagen
assessed.
Results:
our
cohort
68
patients,
53
men
15
women.
Mean
5.97
±
4.37
years.
Hb
negatively
associated
LEDD
(
P
=
0.012)
0.02).
Similarly,
PT
0.041)
0.03).
showed
positive
association
collagen-induced
Conclusions:
study,
using
multiple
higher
observed
have
prothrombotic
Further
studies
needed
confirm
these
findings.
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2514 - 2514
Опубликована: Ноя. 3, 2024
Background/Objectives:
Neuroinflammation
is
associated
with
the
progression
of
various
brain
diseases,
and
management
neuroinflammation-induced
neural
damage
a
crucial
aspect
treating
neurological
disorders.
This
study
investigated
anti-inflammatory
efficacy
photobiomodulation
therapy
(PBMT)
using
660
nm
phototherapy
in
rat
model
lipopolysaccharide
(LPS)-induced
neuroinflammation.
Methods:
We
induced
inflammation
brains
via
intraperitoneal
injection
LPS
subjected
treatment
group
to
examine
its
protective
effect
against
hippocampal
based
on
pathological,
histological,
immunohistochemical
tissue
analyses.
Results:
The
treated
rats
showed
significant
decrease
structural
cell
death
compared
LPS-treated
group.
observed
reduced
expression
markers
GFAP,
TNF-α,
IL-1β
hippocampus
group,
an
increase
SIRT1
across
all
regions.
Conclusions:
presents
promising
method
for
controlling
neuroinflammation
providing
neuroprotection
relief.
PBMT
represents
non-invasive
therapeutic
approach
minimal
side
effects
ensured
through
proper
control
light
irradiation.
