International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 8641 - 8660
Опубликована: Авг. 1, 2024
Osteosarcoma
is
the
predominant
primary
malignant
bone
tumor
that
poses
a
significant
global
health
challenge.
MicroRNAs
(miRNAs)
regulate
gene
expression
are
associated
with
osteosarcoma
pathogenesis.
Thus,
miRNAs
potential
therapeutic
targets
for
osteosarcoma.
Nanoparticles,
widely
used
targeted
drug
delivery,
facilitate
miRNA-based
treatment.
Numerous
studies
have
focused
on
miRNA
delivery
using
nanoparticles
to
inhibit
progress
of
Polymer-based,
lipid-based,
inorganic-based
and
extracellular
vesicles
were
deliver
treatment
They
can
be
modified
enhance
loading
capabilities.
Also,
was
combined
traditional
therapies,
example
chemotherapy,
treat
Consequently,
offers
promising
avenues
osteosarcoma,
providing
renewed
hope
patients.
This
review
emphasizes
utilizing
in
treatment,
then
introduced
summarized
detail.
And
it
also
discusses
prospects
clinical
applications.
Molecules,
Год журнала:
2024,
Номер
29(24), С. 5855 - 5855
Опубликована: Дек. 11, 2024
Cancer
immunotherapy
using
immune
checkpoint
blockades
has
emerged
as
a
promising
therapeutic
approach.
However,
faces
challenges
such
low
response
rates
in
solid
tumors,
necessitating
strategies
to
remodel
the
immune-suppressive
tumor
microenvironment
(TME)
into
an
immune-activated
state.
One
of
primary
approaches
achieve
this
transformation
is
through
induction
immunogenic
cell
death
(ICD).
Herein,
we
discussed
maximize
ICD
nanoparticles.
In
particular,
review
highlighted
various
studies
integrating
chemotherapy,
radiation
therapy
(RT),
photodynamic
(PDT),
and
photothermal
(PTT)
with
nanoparticle-based
immunotherapy.
The
research
covered
aims
provide
valuable
insights
for
future
on
nanoparticle-assisted
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 8641 - 8660
Опубликована: Авг. 1, 2024
Osteosarcoma
is
the
predominant
primary
malignant
bone
tumor
that
poses
a
significant
global
health
challenge.
MicroRNAs
(miRNAs)
regulate
gene
expression
are
associated
with
osteosarcoma
pathogenesis.
Thus,
miRNAs
potential
therapeutic
targets
for
osteosarcoma.
Nanoparticles,
widely
used
targeted
drug
delivery,
facilitate
miRNA-based
treatment.
Numerous
studies
have
focused
on
miRNA
delivery
using
nanoparticles
to
inhibit
progress
of
Polymer-based,
lipid-based,
inorganic-based
and
extracellular
vesicles
were
deliver
treatment
They
can
be
modified
enhance
loading
capabilities.
Also,
was
combined
traditional
therapies,
example
chemotherapy,
treat
Consequently,
offers
promising
avenues
osteosarcoma,
providing
renewed
hope
patients.
This
review
emphasizes
utilizing
in
treatment,
then
introduced
summarized
detail.
And
it
also
discusses
prospects
clinical
applications.
